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List of works by Santina Bruzzone

A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis

scientific article

ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells

scientific article

Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats

scientific article published on 21 October 2015

Abscisic Acid: A Novel Nutraceutical for Glycemic Control

scientific article

Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose

scientific article published on 27 March 2009

Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo

scientific article

Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger

scholarly article

Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger

scientific article

Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis

scientific article published on 30 March 2009

Abscisic acid signaling through cyclic ADP-ribose in hydroid regeneration

scientific article

Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine

scientific article published on 13 December 2018

Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation.

scientific article published on 7 July 2008

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

scientific article published on 8 December 2015

Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes

scientific article

Autocrine abscisic acid plays a key role in quartz-induced macrophage activation

scientific article

Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system

scientific article

Binding of abscisic acid to human LANCL2 ⬇️

scientific article published on October 20, 2011

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells ⬇️

scientific article published on July 23, 2013

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

scientific article

Concentrative influx of functionally active cyclic ADP-ribose in dimethyl sulfoxide-differentiated HL-60 cells

scientific article published on 17 March 2004

Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors

scientific article published on December 2004

Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice

scientific article published on 3 December 2002

Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line

scientific article published on October 2006

Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells

scientific article published on October 2003

Cycling Assay for Determining Intracellular Cyclic ADP-Ribose Levels ⬇️

scientific article published on June 1, 2013

Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.

scientific article published on 3 May 2010

Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules

scientific article published on 25 June 2019

Discovery of novel and selective SIRT6 inhibitors

scientific article

Emerging functions of extracellular pyridine nucleotides

scientific article

Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblasts

scientific article published on 3 October 2002

Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes

scientific article

Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes

scientific article published in February 2006

Fluridone as a new anti-inflammatory drug

scientific article

G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2

scientific article (publication date: 25 May 2016)

Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones

scientific article published in April 2004

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

scientific article published on 14 May 2012

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells

scientific article

Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of CX3CL1

article by Debora Giunti et al published 20 August 2012 in Stem Cells

Mitochondrial Dysfunction Induced by a Cytotoxic Adenine Dinucleotide Produced by ADP-ribosyl Cyclases from cADPR

scientific article published in Journal of Biological Chemistry

NAADP+ is an agonist of the human P2Y11 purinergic receptor

scientific article published on 17 August 2007

NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases

scientific article published on 27 April 2006

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes

scientific article

Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders

scientific article published on January 2013

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

scientific article published on 7 November 2013

P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy

scientific article published on 22 June 2009

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

scientific article published on 6 April 2017

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells

scientific article published on 7 August 2010

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin

scientific article published on 16 March 2017

Regulation of Human Mesenchymal Stem Cell Functions by an Autocrine Loop Involving NAD+ Release and P2Y11-Mediated Signaling

scholarly article by Floriana Fruscione et al published July 2011 in Stem Cells and Development

Rejuvenating sirtuins: the rise of a new family of cancer drug targets

scientific article

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

scientific article published on 19 September 2017

Selectivity hot-spots of sirtuin catalytic cores

scientific article published on July 2015

Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors ⬇️

scientific article published on November 17, 2003

Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells

scientific article

The Diadenosine Homodinucleotide P18 Improves In Vitro Myelination in Experimental Charcot‐Marie‐Tooth Type 1A ⬇️

scientific article published on January 1, 2014

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+ Responses ⬇️

scientific article published on October 18, 2012

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

scientific article

The human immunodeficiency virus-1 protein Tat and its discrete fragments evoke selective release of acetylcholine from human and rat cerebrocortical terminals through species-specific mechanisms.

scientific article published in July 2003

The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts ⬇️

scientific article published on November 10, 2011

The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.

scientific article published in October 2009

Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy.

scientific article published on 16 July 2016

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