List of works - Anna Minarini

Alzheimer's disease: new approaches to drug discovery

scientific article published on 19 May 2009

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.

scientific article published on 3 August 2015

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines

scientific article

Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor

scientific article published on 01 August 1998

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

scientific article published on 10 July 2019

Binding profile of the selective muscarinic receptor antagonist tripitramine.

scientific article published on August 1994

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

scientific article published on 4 April 2016

Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment

scientific article

Cytotoxicity of methoctramine and methoctramine-related polyamines

scientific article

Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality

scientific article published on 8 December 2011

Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators

scientific article published in November 2001

Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as reve

scientific article published on 01 September 1994

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues

scientific article published in November 2004

Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics

scientific article published on 18 June 2008

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent

scientific article

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists

article

Exploiting RNA as a new biomolecular target for synthetic polyamines

scientific article published on 19 April 2013

Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

scientific article published on 01 December 2019

Exploring the effects of isothiocyanates on chemotherapeutic drugs

scientific article published on 03 October 2013

From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease

scientific article published on September 2008

Heterocyclic inhibitors of AChE acylation and peripheral sites

scientific article

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

scientific article

In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer's Disease

scientific article

In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors.

scientific article published on April 1995

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

scientific article published on 8 July 2008

Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies.

scientific article

LC determination of leuprolide component amino acids in injectable solution by phanquinone pre-column derivatization labelling procedure.

scientific article published in April 2005

Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration

scientific article published on November 2006

Macrocyclic naphthalene diimides as G-quadruplex binders

scientific article published on 11 April 2015

Memantine Derivatives as Multitarget Agents in Alzheimer's Disease

scientific article published on 02 September 2020

Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons.

scientific article published on November 2004

Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces

scientific article published on 04 February 2014

Multi-target-directed ligands to combat neurodegenerative diseases

scientific article published on 09 January 2008

Multifunctional tacrine derivatives in Alzheimer's disease

scientific article published on January 2013

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

scientific article published on 20 June 2017

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

scientific article published on 15 April 2016

Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease

scientific article

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

article by Maria Laura Bolognesi et al published 1 May 2011 in Bioorganic & Medicinal Chemistry Letters

Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains

scientific article published on 22 January 2017

Natural polyamines and synthetic analogs modify the growth and the morphology of Pyrus communis pollen tubes affecting ROS levels and causing cell death

scientific article published on 19 July 2015

Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease

scientific article published on 26 October 2015

Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

scientific article published on 24 October 2017

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

scientific article published on 13 September 2007

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases

scientific article published on 01 October 2013

Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.

scientific article published on 8 September 2017

Oxidative stress in Alzheimer's disease: are we connecting the dots?

scientific article

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

scientific article

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents

scientific article published on October 2010

Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy

scientific article published on 01 August 2010

Polymethylene tetraamine backbone as template for the development of biologically active polyamines

scientific article

Preparation, characterization and in vitro evaluation of sterically stabilized liposome containing a naphthalenediimide derivative as anticancer agent

scientific article published on 29 November 2013

Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines.

scientific article

Rational approach to discover multipotent anti-Alzheimer drugs.

scientific article

Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents

scientific article published on January 2007

Recent advances in the design and synthesis of prazosin derivatives

scientific article published on October 2006

Search for selective antagonists at α1-adrenoreceptors: neutral or negative antagonism? ⬇️

scientific article published on April 1, 1998

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine

scientific article published in March 2003

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties

scientific article published in December 2004

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties

scientific article

Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms

scientific article published in April 2002

Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents

scientific article

Study of the cytotoxic effects of the new synthetic Isothiocyanate CM9 and its fullerene derivative on human T-leukemia cells

scientific article

Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagoni

scientific article published in November 1993

Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

scientific article published on 23 November 2011

Synthetic polyamines activating autophagy: effects on cancer cell death

scientific article published in July 2013

Synthetic polyamines: an overview of their multiple biological activities

scientific article published on 10 December 2009

Tacrine derivatives and Alzheimer's disease.

scientific article published on January 2010

Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach.

scientific article

The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists

article by C Melchiorre et al published 1 January 1995 in Life Sciences

Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma

scientific article published on 29 May 2015

Universal Template Approach to Drug Design: Polyamines as Selective Muscarinic Receptor Antagonists ⬇️

scientific article published on October 8, 1998

WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors

scientific article published on 01 October 1999

[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors

scientific article published in 2000

List of works by Anna Minarini

Alzheimer's disease: new approaches to drug discovery

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines

Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor

Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach

Binding profile of the selective muscarinic receptor antagonist tripitramine.

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment

Cytotoxicity of methoctramine and methoctramine-related polyamines

Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality

Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators

Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as reve

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues

Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists

Exploiting RNA as a new biomolecular target for synthetic polyamines

Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

Exploring the effects of isothiocyanates on chemotherapeutic drugs

From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease

Heterocyclic inhibitors of AChE acylation and peripheral sites

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer's Disease

In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors.

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

Isothiocyanate synthetic analogs: biological activities, structure-activity relationships and synthetic strategies.

LC determination of leuprolide component amino acids in injectable solution by phanquinone pre-column derivatization labelling procedure.

Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration

Macrocyclic naphthalene diimides as G-quadruplex binders

Memantine Derivatives as Multitarget Agents in Alzheimer's Disease

Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons.

Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces

Multi-target-directed ligands to combat neurodegenerative diseases

Multifunctional tacrine derivatives in Alzheimer's disease

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains

Natural polyamines and synthetic analogs modify the growth and the morphology of Pyrus communis pollen tubes affecting ROS levels and causing cell death

Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease

Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases

Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.

Oxidative stress in Alzheimer's disease: are we connecting the dots?

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents

Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy

Polymethylene tetraamine backbone as template for the development of biologically active polyamines

Preparation, characterization and in vitro evaluation of sterically stabilized liposome containing a naphthalenediimide derivative as anticancer agent

Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines.

Rational approach to discover multipotent anti-Alzheimer drugs.

Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents

Recent advances in the design and synthesis of prazosin derivatives

Search for selective antagonists at α1-adrenoreceptors: neutral or negative antagonism? ⬇️

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties

Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms

Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents

Study of the cytotoxic effects of the new synthetic Isothiocyanate CM9 and its fullerene derivative on human T-leukemia cells

Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagoni

Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

Synthetic polyamines activating autophagy: effects on cancer cell death

Synthetic polyamines: an overview of their multiple biological activities

Tacrine derivatives and Alzheimer's disease.

Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach.

The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists

Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma

Universal Template Approach to Drug Design: Polyamines as Selective Muscarinic Receptor Antagonists ⬇️

WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors

[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors