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List of works by Adrian J Hobbs

A Comparison of the Chemical Biology of Hydropersulfides (RSSH) with other Protective Biological Antioxidants and Nucleophiles

scientific article published on 27 November 2020

A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction?

scientific article published on 01 July 2016

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite

scientific article

Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90)

scientific article published on 23 April 2018

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

scholarly article

Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.

scientific article published in October 2003

Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta.

scientific article published in November 1999

BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.

scientific article published in February 2003

Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences

scientific article published on 26 May 2015

Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity

scientific article published on 01 October 1999

Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta

scientific article published on 01 December 2006

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology

scientific article published on 24 May 2018

Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide.

scientific article

C-type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature ⬇️

scientific article published on 08 May 2019

C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target

scientific article published on January 2010

C-type natriuretic peptide co-ordinates cardiac structure and function

scientific article published on 01 March 2020

C-type natriuretic peptide in vascular physiology and disease.

scientific article

C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes.

scientific article published on 22 August 2015

C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling.

scientific article

Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor

scientific article published on 12 May 2008

Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.

scientific article published on 2 June 2008

Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice.

scientific article published on 15 February 2008

Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology

scientific article

Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO

scientific article published on 01 October 1993

Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation

scientific article published on 01 April 1991

Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor

scientific journal article

Design and development of novel non-peptide agonists at NPR-C.

scientific article published in August 2011

Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions ⬇️

scientific article published on November 1, 1991

Distinct endothelial pathways underlie sexual dimorphism in vascular auto‐regulation ⬇️

scientific article published on October 1, 2012

Effects of low-dose aspirin on acute inflammatory responses in humans.

scientific article

Endothelial C-type natriuretic peptide maintains vascular homeostasis

scientific article

Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.

scientific article published in November 2013

Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential

scientific article

Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis.

scientific article published in August 2011

Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS

scientific article

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

scientific article published in November 1994

Functional pharmacological characterization of SER100 in cardiovascular health and disease

scientific article published on 25 September 2016

Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves

scientific article published on 01 October 2000

Guanylyl cyclase can't stand the HETE

scientific article published on 03 May 2016

Haemoglobin: NO transporter, NO inactivator or NOne of the above?

scientific article

Inflammasomes: a novel therapeutic target in pulmonary hypertension?

scientific article published on 27 June 2018

Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension

scientific article

Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.

scientific article

Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis

scientific article published on July 2014

Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis.

scientific article published on 2 September 2015

Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.

scientific article published on 7 February 2005

IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD.

scientific article published on 6 May 2016

L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle

scientific article published on March 1990

L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle.

scientific article published on August 1990

LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.

scientific article published on 14 July 2011

Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis

scientific article published on 6 August 2009

Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.

scientific article published on 9 May 2003

Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules ⬇️

scientific article published on December 9, 2011

Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension.

scientific article

Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.

scientific article published on 25 September 2008

NO-independent, haem-dependent soluble guanylate cyclase stimulators

scientific article

Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide

scientific journal article

Natriuretic peptide receptors and heart failure: to B or not to B blocked?

scientific article

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model.

scientific article published on 24 July 2013

Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial

scientific article published on 31 March 2019

New perspectives for the treatment of pulmonary hypertension

scientific article

Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo.

scientific article published in July 1996

Nitric oxide-cyclic GMP signal transduction system.

scientific article published on January 1996

Novel aspects of endothelium-dependent regulation of vascular tone.

scientific article published on 12 July 2006

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure

scientific article published on 16 July 2018

Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury.

scientific article

Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP).

scientific article published on 2 September 2015

Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation.

scientific article

Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.

scientific article published on 5 February 2003

Raised arterial blood pressure in neurokinin-1 receptor-deficient mice (NK1R(-/-) ): evidence for a neural rather than a vascular mechanism

scientific article published on 09 April 2016

Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.

scientific article

Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo.

scientific article

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility

scientific article

Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A

scientific article published on August 2010

Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function

scientific article published on 31 July 2014

Soluble guanylate cyclase: an old therapeutic target re-visited.

scientific article published in July 2002

Soluble guanylate cyclase: the forgotten sibling.

scientific article published on December 1997

Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.

scientific article published on 8 August 2008

Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe

scientific article published on 01 April 2000

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.

scientific article published on 10 October 2017

The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols.

scientific article published on 15 June 2009

The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle.

scientific article

The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle

scientific article published on 01 June 1993

The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer?

scientific article

The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

scientific article

The role of cGMP signalling in auditory processing in health and disease

scientific article published in 2021

Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms.

scientific article published on 23 January 2004

Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.

scientific article published on August 2003

Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application.

scientific article published on January 2013

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