List of works - Luigi Scipione

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

scientific article published on 25 September 2015

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

scientific article published on 5 November 2013

Activity of caffeic acid derivatives against Candida albicans biofilm.

scientific article published on 13 February 2014

Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase

scientific article

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

scientific article published on 28 June 2018

Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats.

scientific article published on 21 July 2006

Comparison of different methods for the extraction of cannabinoids from cannabis

scientific article published on 29 April 2019

Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors

scientific article published on 11 February 2014

Design, synthesis, and structure-activity relationship of N-arylnaphthylamine derivatives as amyloid aggregation inhibitors

scientific article published in October 2012

Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4

scientific article

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

scientific article published on 22 June 2015

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

scientific article

Dithionite adducts of pyridinium salts: regioselectivity of formation and mechanisms of decomposition

article

Efficient Synthesis of 3,5-Dicarbamoyl-1,4-dihydropyridines from Pyridinium Salts: Key Molecules in Understanding NAD(P)+/NAD(P)H Pathways

Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats

scientific article

Electrogenerated acetonitrile anion induced selective N-alkylation of bifunctional compounds

Evaluation of the Anti-<i>Histoplasma capsulatum</i> Activity of Indole and Nitrofuran Derivatives and Their Pharmacological Safety in Three-Dimensional Cell Cultures

scientific article published on 12 May 2022

Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicans.

scientific article published on November 2016

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

scientific article published in December 2017

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties.

scientific article published in December 2017

In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.

scientific article

Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase.

scientific article published in October 2002

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

scientific article

New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation

scientific article published on 3 September 2016

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

scientific article published on 7 May 2013

New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target

scientific article

New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation

scientific article published on 18 September 2017

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity

scientific article published on 30 July 2018

Pharmacophore Assessment Through 3-D QSAR: Evaluation of the Predictive Ability on New Derivatives by the Application on a Series of Antitubercular Agents

scientific article published on 17 May 2013

Role of Calcium in the Reaction between Pyrroloquinoline Quinone and Pyridine Nucleotides Monomers and Dimers

scientific article published on 01 August 1999

Simple choline esters as potential anti-Alzheimer agents.

scientific article published in January 2010

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

scientific article published on 27 March 2017

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain

scientific article published on 11 February 2015

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

article

Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives

scientific article published on 26 January 2012

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats ⬇️

scientific article published on November 3, 2003

Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

scientific article

Towards a new application of amaranth seed oil as an agent against Candida albicans

scientific article published on 04 December 2019

List of works by Luigi Scipione

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

Activity of caffeic acid derivatives against Candida albicans biofilm.

Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats.

Comparison of different methods for the extraction of cannabinoids from cannabis

Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors

Design, synthesis, and structure-activity relationship of N-arylnaphthylamine derivatives as amyloid aggregation inhibitors

Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

Dithionite adducts of pyridinium salts: regioselectivity of formation and mechanisms of decomposition

Efficient Synthesis of 3,5-Dicarbamoyl-1,4-dihydropyridines from Pyridinium Salts: Key Molecules in Understanding NAD(P)+/NAD(P)H Pathways

Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats

Electrogenerated acetonitrile anion induced selective N-alkylation of bifunctional compounds

Evaluation of the Anti-<i>Histoplasma capsulatum</i> Activity of Indole and Nitrofuran Derivatives and Their Pharmacological Safety in Three-Dimensional Cell Cultures

Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicans.

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties.

In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.

Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase.

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target

New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity

Pharmacophore Assessment Through 3-D QSAR: Evaluation of the Predictive Ability on New Derivatives by the Application on a Series of Antitubercular Agents

Role of Calcium in the Reaction between Pyrroloquinoline Quinone and Pyridine Nucleotides Monomers and Dimers

Simple choline esters as potential anti-Alzheimer agents.

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats ⬇️

Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

Towards a new application of amaranth seed oil as an agent against Candida albicans