List of works by Giovanni Capranico

10th Conference on DNA Topoisomerases in therapy

scientific article published on 01 December 1999

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons.

scientific article

A rational selection of drug targets needs deeper insights into general regulation mechanisms

scientific article published in September 2004

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors

scientific article published on 09 December 2008

A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin.

scientific article published on May 1993

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

scientific article published on 01 December 1996

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives ⬇️

scientific article published on 6 November 2018

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

scientific article published on 2 September 2013

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

scientific article published on 01 February 2004

Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.

scientific article

Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line

scientific article published on November 18, 1992

Characterization of novel antisense HIF-1α transcripts in human cancers

scientific article published on 15 September 2011

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

scientific article published on 01 May 1999

Conformational drug determinants of the sequence specificity of drug-stimulated topoisomerase II DNA cleavage

scientific article published on 01 January 1994

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

scientific article published on 01 September 1994

Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.

scientific article published on 30 April 2013

DNA Topoisomerase I differentially modulates R-loops across the human genome

scientific article published on 30 July 2018

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

scientific article published on 27 December 2018

DNA sequence selectivity of topoisomerases and topoisomerase poisons.

scientific article published in October 1998

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus

scientific article

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

scientific article published on January 2007

DNA topoisomerase-trapping antitumour drugs

scientific article published on January 1, 1992

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

scientific article published on 17 November 2015

DROPA: DRIP-seq optimized peak annotator ⬇️

scientific article published on 06 August 2019

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent

scientific article

Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges

scientific article published in July 2004

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

scientific article published on August 17, 1992

Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung

scientific article published on 01 December 1995

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

scientific article

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity

scientific article published on 27 June 2010

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs ⬇️

scientific article published on December 20, 1991

Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line.

scientific article published in February 1988

Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo.

scientific article published on August 1997

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

scientific article published on 01 September 2019

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

scientific article published on 19 January 2016

Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells

scientific article published on 6 January 2006

Effects of common buffer systems on drug activity: the case of clerocidin.

scientific article

Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: a different look of the ternary complex.

scientific article

Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins

scientific article published in March 2004

Formation, resealing and persistence of DNA breaks produced by 4-demethoxydaunorubicin in P388 leukemia cells

scientific article published on 01 January 1989

G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells

scientific article published on 01 July 2021

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

scientific article published on 13 April 2006

Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma

scientific article published on 01 August 1996

Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion

scientific article

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.

scientific article published on 18 April 2012

Interaction model for anthracycline activity against DNA topoisomerase II.

scientific article published in June 2004

Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation.

scientific article published on January 2007

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

scientific article published on November 1991

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

scientific article published in November 1990

MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.

scientific article

Mapping DNA Breaks by Next-Generation Sequencing

scientific article published in January 2018

Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.

scientific article published on May 1998

Mechanism of action of DNA topoisomerase inhibitors.

scientific article published on July 1995

Metallothionein cDNA cloning, metallothionein expression and heavy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy.

scientific article published on 17 January 2011

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

scientific article published on 18 March 2020

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism

scientific article

Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.

scientific article published on 27 August 2012

New developments in antitumor anthracyclines.

scientific article published on October 1997

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

scientific article published on 17 July 2014

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening

scientific article

Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.

scientific article published on 18 January 2005

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.

scientific article published in August 1990

Peptidyl Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA Binding, Redox Cycling, and Biological Activity

scientific article published on 01 August 1996

Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones

scientific article published on 01 January 1997

Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.

scientific article published in January 1996

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

scientific article published on 15 November 2017

Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene

scientific article

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.

scientific article published on 19 December 2016

Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues

scientific article published on 01 January 1998

The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I.

scientific article published on 21 January 2007

The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells

scientific article published on 19 November 2013

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

article

Type I DNA Topoisomerases

scientific article published on 10 January 2017

Paulina is supported by:

About Paulina

Help