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List of works by Frédéric Relaix

A Pax3/Pax7-dependent population of skeletal muscle progenitor cells

scientific article

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

scientific article published on 24 February 2022

A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300

scientific journal article

A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb

scientific article

A p57 conditional mutant allele that allows tracking of p57-expressing cells

scientific article published on 14 February 2017

Activated Muscle Satellite Cells Chase Ghosts

scientific article published on 01 February 2016

Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode

scientific article published on 07 December 2008

Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.

scientific article

Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest

scientific article published in July 2014

BMP signaling regulates satellite cell-dependent postnatal muscle growth

scientific article published on 10 July 2017

Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity

scientific article published on 09 January 2007

Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest

scientific article published on 13 July 2008

Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells

scientific article published on 04 October 2018

Characterization of Pax3-expressing cells from adult blood vessels

scientific article published on 8 December 2011

Conserved functions of PAX3/7 during evolution

Conserved functions of Pax3/7 during evolution

Current concepts on skeletal muscle formation and stem cells

Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy.

scientific article published on February 2014

Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy

scientific article

Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

scientific article published on 17 May 2021

Direct isolation of satellite cells for skeletal muscle regeneration

scientific article published in September 2005

Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube

scientific article

Divergent functions of murine Pax3 and Pax7 in limb muscle development

scientific journal article

Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis

scientific article

Generation of BAC transgenic tadpoles enabling live imaging of motoneurons by using the urotensin II-related peptide (ust2b) gene as a driver

scientific article

Genetic regulation of skeletal muscle development

scientific article published on 07 September 2010

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes

scientific journal article

HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth.

scientific article

HIRA stabilizes skeletal muscle lineage identity

scientific article published on 08 June 2021

Heterochromatin compaction is regulated by Suv4-20h1 to maintains skeletal muscle stem cells quiescence

scientific article published on 20 June 2016

Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells.

scientific article published on September 2016

In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells

scientific article published in November 2017

In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium

scientific article published on 04 November 2019

Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation

scientific article

Involvement of vessels and PDGFB in muscle splitting during chick limb development

scientific article published on 6 June 2007

Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo

scientific article

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice

scientific article published on 15 October 2016

LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription.

scientific article published in February 2017

Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents

scientific article published on 21 April 2011

Muscle contraction is necessary to maintain joint progenitor cell fate

scientific article

Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity

scholarly article

Muscle stem cells

Myogenic precursor cells

Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential

scientific article published on 13 October 2006

Necroptosis mediates myofibre death in dystrophin-deficient mice

scientific article published in Nature Communications

Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling

scientific article published on 21 July 2011

Notch pathway: from development to regeneration of skeletal muscle

scientific article published on 25 May 2011

Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb

scientific article

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.

scientific article published on 31 October 2017

Origine du muscle squelettique : rôles de Pax3/Pax7

Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration and causes outflow tract defects

scientific article

P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.

scientific article

PAX3 and PAX7 as upstream regulators of myogenesis

scientific article published on 27 September 2015

PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

scientific article published on 18 December 2017

PW1 gene/paternally expressed gene 3 (PW1/Peg3) identifies multiple adult stem and progenitor cell populations

scientific article

Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin.

scientific article published in July 2011

Pax genes: Master regulators of development and tissue homeostasis

scientific article published on 01 August 2015

Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells.

scientific article

Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects

scientific article

Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program

scientific article

Pax3( GFP ) , a new reporter for the melanocyte lineage, highlights novel aspects of PAX3 expression in the skin

scientific article published on 12 July 2012

Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons

scientific article published on 15 June 2017

Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular Cell Fate Choice in Multipotent Progenitors

scientific article published on 01 December 2009

Pax7 and myogenic progression in skeletal muscle satellite cells

scientific article

Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.

scientific article

Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence

scientific article

Pericytes in the myovascular niche promote postnatal myofiber growth and satellite cell quiescence

Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters

scientific article published on 15 December 2015

Progressive and Coordinated Mobilization of the Skeletal Muscle Niche throughout Tissue Repair Revealed by Single-Cell Proteomic Analysis

scientific article published on 29 March 2021

Publisher Correction: Necroptosis mediates myofibre death in dystrophin-deficient mice

scientific article published in Nature Communications

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis

scientific article

Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche

scientific article published in Nature

Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7.

scientific article

RhoA and ERK signalling regulate the expression of the transcription factor Nfix in myogenic cells

scientific article published on 28 September 2018

Role of muscle stem cells during skeletal regeneration

scientific article published in May 2015

SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity.

scientific article

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage ⬇️

scientific article published on August 1, 2012

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

scientific article

Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis.

scientific article

Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

scientific article published on 09 October 2020

Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis

scientific article

Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation

scientific article published on 9 December 2004

Skeletal Muscle Differentiation of Embryonic Mesoangioblasts Requires Pax3 Activity

scientific article published on 01 January 2009

Skeletal muscle progenitor cells: from embryo to adult.

scientific article

Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome

scientific article

Stress-induced decrease in TRAF2 stability is mediated by Siah2

scientific article

The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition

scientific article published on 11 November 2020

The formation of skeletal muscle: from somite to limb

scientific article

The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts.

scientific article published on May 2004

The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system

scientific article published on 7 December 2008

The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions

scientific article published on January 2007

The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.

scientific article

Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis.

scientific article published in August 1996

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo

scientific article

Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning

scientific article published on 22 June 2021

Waking up muscle stem cells: PI3K signalling is ringing

[Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects].

scientific article

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