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List of works by Wenshe R Liu

A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7

scientific article published on 04 February 2019

A Facile Method to Synthesize Histones with Posttranslational Modification Mimics ⬇️

scientific article published on June 19, 2012

A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation.

scientific article published on 2 December 2016

A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library

scientific article published on 09 September 2019

A Novel Y-Shaped, S-O-N-O-S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease

A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors

scientific article published on 28 July 2020

A Versatile Approach for Site-Specific Lysine Acylation in Proteins

scientific article published on 2 January 2017

A click chemistry approach to site-specific immobilization of a small laccase enables efficient direct electron transfer in a biocathode

scientific article published on 01 February 2015

A facile system for genetic incorporation of two different noncanonical amino acids into one protein in Escherichia coli.

scientific article published in April 2010

A genetically encoded acrylamide functionality

scientific article published on 18 June 2013

A genetically encoded aldehyde for rapid protein labelling

scientific article

A genetically encoded bidentate, metal-binding amino acid

scientific article

A genetically encoded diazirine photocrosslinker in Escherichia coli

scientific article

A genetically encoded photocaged Nepsilon-methyl-L-lysine.

scientific article published on 30 March 2010

A rationally designed pyrrolysyl-tRNA synthetase mutant with a broad substrate spectrum

scientific article published on 6 February 2012

Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition

scientific article

An amber obligate active site-directed ligand evolution technique for phage display

scientific article published on 13 March 2020

Catalyst-free and site-specific one-pot dual-labeling of a protein directed by two genetically incorporated noncanonical amino acids

scientific article

Covalent Inhibition in Drug Discovery

scientific article published on 26 March 2019

E1-catalyzed ubiquitin C-terminal amidation for the facile synthesis of deubiquitinase substrates

scientific article published on 16 December 2013

Effects of End Group Termination on Salting-Out Constants for Triglycine

scientific article published on December 2013

Evolving the N-Terminal Domain of Pyrrolysyl-tRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids.

scientific article published on 2 November 2017

Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids

scientific article published on 18 November 2014

Expressed Protein Ligation without Intein

scientific article published on 02 April 2020

Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid

scientific article published on June 2015

Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membrane Insertion

scientific article published on 19 June 2015

Genetic code expansion: Synthetases pick up the PACE.

scientific article

Genetic incorporation of an aliphatic keto-containing amino acid into proteins for their site-specific modifications

scientific article published on 24 December 2009

Genetic incorporation of seven ortho-substituted phenylalanine derivatives

scientific article published on 27 January 2014

Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant

scientific article published on 19 November 2012

Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking.

scientific article published on 19 April 2017

Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader

scientific article

Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

scientific article

Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

scientific article published on 17 October 2019

Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification.

scientific article published on 13 January 2015

Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.

scientific article published on 13 February 2018

Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase.

scientific article published in May 2004

Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV

scientific article published on 25 February 2020

Near-cognate suppression of amber, opal and quadruplet codons competes with aminoacyl-tRNAPyl for genetic code expansion.

scientific article published on October 2012

Nonsense and sense suppression abilities of original and derivative Methanosarcina mazei pyrrolysyl-tRNA synthetase-tRNA(Pyl) pairs in the Escherichia coli BL21(DE3) cell strain

scientific article

Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically Encoded N ε -Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent

Phospha-Michael Addition as a New Click Reaction for Protein Functionalization.

scientific article published on 12 January 2016

Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics.

scientific article

Proteins with Site-Specific Lysine Methylation.

scientific article

Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool

scientific article

Reports from the Chemical Biology of Texas Symposium at the 69th Southwest Regional Meeting of the American Chemical Society

scientific article published on 01 February 2014

Reversal of the hofmeister series: specific ion effects on peptides.

scientific article published in July 2013

Role of Q52 in catalysis of decarboxylation and transamination in dialkylglycine decarboxylase.

scientific article

Selecting folded proteins from a library of secondary structural elements.

scientific article

Sirtuins 1 and 2 Are Universal Histone Deacetylases

scientific article published on 28 January 2016

Stepwise Assembly of Turn-on Fluorescence Sensors in Multicomponent Metal-Organic Frameworks for in Vitro Cyanide Detection

scientific article published on 15 March 2020

Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases

scientific article

Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

scientific article published in Nature Communications

Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach.

scientific article

Targeting the SARS-CoV-2 Main Protease to Repurpose Drugs for COVID-19

scientific article published on 23 May 2020

The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification

scientific article published on March 2016

The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

scientific article published on 10 September 2020

The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives.

scientific article published on 14 January 2011

The genetic incorporation of thirteen novel non-canonical amino acids

scientific article

The nitrilimine-alkene cycloaddition is an ultra rapid click reaction

scientific article published on 12 February 2014

Towards reassigning the rare AGG codon in Escherichia coli

scientific article (publication date: 18 August 2014)

Two rapid catalyst-free click reactions for in vivo protein labeling of genetically encoded strained alkene/alkyne functionalities

scientific article

tRNAPyl: Structure, function, and applications.

scientific article published on 24 August 2017

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