List of works - Sebastian Furness

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

scientific article

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death.

scientific article published on 10 October 2016

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.

scientific article published on April 2013

Activation of the GLP-1 receptor by a non-peptidic agonist

scientific article published on 08 January 2020

Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator.

scientific article published on 15 March 2010

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

scientific article

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

scientific article

Coding GPCR-G protein specificity.

scientific article published on 11 July 2017

Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

scientific article published on 26 July 2019

Consequences of splice variation on Secretin family G protein-coupled receptor function

scientific article

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

scientific article

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

scientific article published on 25 August 2018

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

scientific article published on 18 February 2019

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

scientific article published on 15 February 2018

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

scientific article

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

scientific article

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

scientific article published on 6 October 2016

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.

scientific article published on March 2014

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

scientific article published on 21 February 2018

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

scientific article

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

scientific article published on February 2013

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

scientific article published on 28 August 2012

Structure and dynamics of the active Gs-coupled human secretin receptor

scientific article published on 18 August 2020

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

scientific article published in Nature

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

scientific article published on 04 June 2021

Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications

scientific article

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

scientific article

The Molecular Control of Calcitonin Receptor Signaling

scientific article published on 11 January 2019

The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172.

scientific article

The nature of efficacy at G protein-coupled receptors

scientific article published on 01 October 2019

The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles.

scientific article published on 23 September 2009

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

scientific article published on 27 August 2019

Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.

scientific article published on 30 August 2012

List of works by Sebastian Furness

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death.

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.

Activation of the GLP-1 receptor by a non-peptidic agonist

Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator.

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Coding GPCR-G protein specificity.

Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

Consequences of splice variation on Secretin family G protein-coupled receptor function

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

Structure and dynamics of the active Gs-coupled human secretin receptor

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

The Molecular Control of Calcitonin Receptor Signaling

The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172.

The nature of efficacy at G protein-coupled receptors

The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles.

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.