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List of works by Christopher A Ahern

A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels

scientific article published in May 2015

A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels.

scientific article

A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block.

scientific article published on 19 January 2007

A component of excitation-contraction coupling triggered in the absence of the T671-L690 and L720-Q765 regions of the II-III loop of the dihydropyridine receptor alpha(1s) pore subunit.

scientific article

A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.

scientific article published on January 2013

An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels

scientific article

Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

scientific article published on May 2014

Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology

scientific article

Atomic basis for therapeutic activation of neuronal potassium channels

scientific article

Atomic determinants of BK channel activation by polyunsaturated fatty acids

scientific article

Atomic mutagenesis in ion channels with engineered stoichiometry

scientific article published on 6 October 2016

Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis

scientific article published on 7 September 2010

Blockade of Permeation by Potassium but Normal Gating of the G628S Nonconducting hERG Channel Mutant ⬇️

scientific article published on August 3, 2011

Ca2+-dependent excitation-contraction coupling triggered by the heterologous cardiac/brain DHPR beta2a-subunit in skeletal myotubes

scientific article

Cellular encoding of Cy dyes for single-molecule imaging.

scientific article published on 12 December 2016

Chemical tools for K(+) channel biology

scientific article

Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid.

scientific article

Contributions of conserved residues at the gating interface of glycine receptors.

scientific article

Contributions of counter-charge in a potassium channel voltage-sensor domain.

scientific article published on 24 July 2011

Cross-kingdom auxiliary subunit modulation of a voltage-gated Sodium channel

scientific article published on 25 January 2018

Crystallographic basis for calcium regulation of sodium channels ⬇️

scientific article published on February 13, 2012

Divergent Cl-and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

scientific article published on 28 April 2020

Engineered transfer RNAs for suppression of premature termination codons

scientific article published on 18 February 2019

Expanding Genetic Code Expansion through Resource Facilities, Workshops, and Conferences. ⬇️

scientific article

Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes

scientific article published on January 2013

Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes.

scientific article published on 6 September 2012

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

scientific article published on 10 February 2014

Identification and quantification of newly synthesized proteins translationally regulated by YB-1 using a novel Click-SILAC approach.

scientific article published on 5 September 2012

Incorporation of Non-Canonical Amino Acids

scientific article published on January 2015

Intermediate state trapping of a voltage sensor

scientific article

Intramembrane charge movements and excitation- contraction coupling expressed by two-domain fragments of the Ca2+ channel.

scientific article

Introduction: Applying Chemical Biology to Ion Channels

scientific article published on 01 January 2015

Investigating the putative glycine hinge in Shaker potassium channel.

scientific article

Involvement of the carboxy-terminus region of the dihydropyridine receptor beta1a subunit in excitation-contraction coupling of skeletal muscle

scientific article

Ketamine, at clinical concentrations, does not alter the function of cardiac sarcoplasmic reticulum calcium release channels.

scientific article published in October 1995

Local anesthetic inhibition of a bacterial sodium channel

scientific article published on June 2012

Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

scientific article published in Nature Communications

Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits

scientific article published on 21 February 2018

Modulation of the cardiac sodium channel NaV1.5 by Fyn, a Src family tyrosine kinase.

scientific article

Molecular Origin of the L-Type Ca2+ Current of Skeletal Muscle Myotubes Selectively Deficient in Dihydropyridine Receptor β1a Subunit ⬇️

scientific article published on July 1, 1998

Molecular and functional determinants of local anesthetic inhibition of NaChBac.

scientific article published on September 2012

Molecular characterization of a two-domain form of the neuronal voltage-gated P/Q-type calcium channel alpha(1)2.1 subunit

scientific article published on December 2002

Nη-substituted arginyl peptide inhibitors of protein arginine N-methyltransferases.

scientific article published on November 2010

Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte.

scientific article

Pharmacological insights and quirks of bacterial sodium channels.

scientific article published on January 2014

Rapid evolution of a voltage-gated sodium channel gene in a lineage of electric fish leads to a persistent sodium current

scientific article published on 27 March 2018

Removal of Mg2+ inhibition of cardiac ryanodine receptor by palmitoyl coenzyme A

scientific article published on 01 October 1994

Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape.

scientific article published on 4 June 2018

Stirring up controversy with a voltage sensor paddle.

scientific article published on June 2004

Structural basis of α-scorpion toxin action on Nav channels

scientific article

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

scientific article

The hitchhiker's guide to the voltage-gated sodium channel galaxy

scientific article

The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro

scientific article published in June 2011

The secret lives of voltage sensors.

scientific article published on 9 August 2007

Truncation of the carboxyl terminus of the dihydropyridine receptor beta1a subunit promotes Ca2+ dependent excitation-contraction coupling in skeletal myotubes.

scientific article

Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.

scientific article published on January 2013

What activates inactivation?

scientific article published on 15 July 2013

γ1Subunit Interactions within the Skeletal Muscle L-type Voltage-gated Calcium Channels

scientific article published on 29 October 2002

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