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List of works by Rick Greupink

A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women.

scientific article published on 8 March 2018

Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically-Based Pharmacokinetic Modeling

scientific article published on 23 December 2019

Convallatoxin: a new P-glycoprotein substrate

scientific article published on 28 September 2014

Corrigendum to 'Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs' [European Journal of Pharmaceutical Sciences 115 (2018) 175-184]

article

Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

scientific article published on 5 January 2018

Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT)

scientific article published on 19 April 2019

Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations.

scientific article published on 19 January 2018

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1.

scientific article published on 17 December 2012

Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon.

scientific article

Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling

scientific article published on 01 May 2019

Experimental study of diclofenac and its biliary metabolites on anastomotic healing

scientific article published on 17 May 2018

Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.

scientific article

First reported use of elvitegravir and cobicistat during pregnancy.

scientific article

Free dug concentrations in pregnancy: Bound to measure unbound?

scientific article

In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.

scientific article published on 23 April 2014

Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3.

scientific article published on 6 May 2014

Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP).

scientific article published on 16 September 2011

Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4.

scientific article published on 12 September 2013

Mannose-6-phosphate/insulin-Like growth factor-II receptors may represent a target for the selective delivery of mycophenolic acid to fibrogenic cells.

scientific article published on August 2006

Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats

scientific article published on 06 April 2018

Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps

scientific article published on 01 March 2019

Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats

scientific article published on 15 December 2006

Pharmacological considerations on the use of antiretrovirals in pregnancy.

scientific article published on December 2013

Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy

scientific article published on 14 September 2015

Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue

scientific article published on 12 April 2018

Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model

scientific article published on 3 November 2015

Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling

scientific article

Rat precision-cut liver slices predict drug-induced cholestatic injury

scientific article published on 8 April 2017

Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child

scientific article published on 25 August 2019

Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.

scientific article published on 7 February 2006

Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug–drug-interactions ⬇️

scientific article published on June 24, 2013

Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.

scientific article published on 4 June 2005

Substantially lowered dolutegravir exposure in a treatment-experienced perinatally HIV-1-infected pregnant woman.

scientific article published on July 2016

Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated.

scientific article published on March 2007

The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo.

scientific article published on 26 January 2006

Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

scientific article published on 15 September 2017

Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity

scientific article published on 09 January 2019

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