List of works by Katia Scotlandi

4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients.

scientific article published on September 2005

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

scientific article

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

scientific article published on 29 June 2018

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

scientific article

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS

scientific article published on 15 August 2018

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas.

scientific article

Analysis of P-glycoprotein expression in osteosarcoma

scientific article published on 01 November 1995

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015

Anticancer effects of zoledronic acid against human osteosarcoma cells.

scientific article published on June 2006

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

scientific article

Biological indicators of prognosis in Ewing's sarcoma: an emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP).

scientific article

Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99. Efficient large scale purification from periplasmic inclusion bodies in E. coli expression system

scientific article

C-kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions.

scientific article published in May 2003

CD99 acts as an oncosuppressor in osteosarcoma

scientific article

CD99 at the crossroads of physiology and pathology

scientific article published on 6 January 2018

CD99 drives terminal differentiation of osteosarcoma cells by acting as a spatial regulator of ERK 1/2.

scientific article

CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity.

scientific article published on 30 April 2007

CD99 polymorphisms significantly influence the probability to develop Ewing sarcoma in earlier age and patient disease progression

scientific article published on 25 October 2016

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

scientific article published on 30 November 2015

CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity.

scientific article published on 6 May 2013

CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin

scientific article published on 11 December 2014

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

scientific article

CD99: A Cell Surface Protein with an Oncojanus Role in Tumors.

scientific article published on 13 March 2018

CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients.

scientific article published on 28 September 2015

Calcitonin down-regulates immediate cell signals induced in human osteoclast-like cells by the bone sialoprotein-IIA fragment through a postintegrin receptor mechanism

scientific article published on 01 March 1995

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

scientific article published on 22 August 2016

Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.

scientific article published on August 2007

Caveolins in the development and diseases of musculoskeletal system.

scientific article published on 03 April 2009

Cell growth inhibition and apoptotic effect of the rexinoid 6-OH-11-O-hydroxyphenantrene on human osteosarcoma and mesenchymal stem cells.

scientific article

Characterization of human mesenchymal stem cells from ewing sarcoma patients. Pathogenetic implications

scientific article published on 3 February 2014

Circulating miR34a levels as a potential biomarker in the follow-up of Ewing sarcoma

scientific article published on 05 June 2020

Clinical Significance of Tumor Protein D52 Immunostaining in a Large Series of Ewing's Sarcoma Family of Tumors

scientific article published on 21 February 2011

Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma.

scientific article

Clinical relevance of Ki-67 expression in bone tumors

scientific article published on 01 February 1995

Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of Tumors

scientific article published on 01 March 2011

Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99.

scientific article published on 31 January 2018

Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors

scientific article published on 14 January 2009

Construction of Human Naïve Antibody Gene Libraries

article

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

scientific article published on January 2004

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias

scientific article published on 24 March 2014

Defining Ewing and Ewing-like small round cell tumors (SRCT): The need for molecular techniques in their categorization and differential diagnosis. A study of 200 cases

scientific article published on 14 March 2016

Design and construction of a new human naïve single-chain fragment variable antibody library, IORISS1.

scientific article

Designing novel therapies against sarcomas in the era of personalized medicine and economic crisis.

scientific article published on January 2013

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.

scientific article published in February 2002

ERG deregulation induces IGF-1R expression in prostate cancer cells and affects sensitivity to anti-IGF-1R agents.

scientific article published on June 2015

Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival

scientific article published in May 2009

Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?

scientific article published on 17 August 2012

Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice.

scientific article published on 23 February 2018

Evaluation of P-glycoprotein expression in soft tissue sarcomas of the extremities

scientific article published on 01 January 1996

Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors

scientific article published on 01 December 1992

Expression Profiling of Osteosarcoma Cells Transfected with MDR1 and NEO Genes: Regulation of Cell Adhesion, Apoptosis, and Tumor Suppression-Related Genes ⬇️

scientific article published on April 1, 2003

Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells

scientific article published on 20 January 2014

Expression of HER/erbB family of receptor tyrosine kinases and induction of differentiation by glial growth factor 2 in human rhabdomyosarcoma cells

scientific article published on 01 July 2000

Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome

scientific article published on 01 November 1995

Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

scientific article published on September 2002

Expression of insulin-like growth factor system components in Ewing's sarcoma and their association with survival.

scientific article

Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma

scientific article published on 29 May 1997

Generation of human single-chain antibody to the CD99 cell surface determinant specifically recognizing Ewing's sarcoma tumor cells.

scientific article

Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone

article

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

scientific article published on 6 December 2017

Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.

scientific article published in September 2003

Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors

scientific article published on 14 April 2020

High metastatic efficiency of human sarcoma cells in Rag2/gammac double knockout mice provides a powerful test system for antimetastatic targeted therapy.

scientific article published on 22 December 2009

Human myeloma cell lines induce osteoblast downregulation of CD99 which is involved in osteoblast formation and activity.

scientific article published on 27 April 2015

IGF system in sarcomas: a crucial pathway with many unknowns to exploit for therapy

scientific article published on 22 December 2017

IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells

scientific article

Identification of candidate genes involved in the reversal of malignant phenotype of osteosarcoma cells transfected with the liver/bone/kidney alkaline phosphatase gene.

scientific article published on April 2004

Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma.

scientific article

Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.

scientific article

Identification of miR-187 and miR-182 as biomarkers of early diagnosis and prognosis in patients with prostate cancer treated with radical prostatectomy.

scientific article

Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing's sarcoma family of tumors (ESFT).

scientific article published on 14 February 2018

Immunoreactivity using anti-ERG monoclonal antibodies in sarcomas is influenced by clone selection

scientific article

Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor.

scientific article published on April 1996

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014

In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type

scientific article (publication date: 23 June 2005)

In vivo and in vitro production of haemopoietic colony-stimulating activity by murine cell lines of different origin: a frequent finding

article

Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma

scientific article published on 24 April 2020

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R.

scientific article published on 20 April 2018

Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status

scientific article

Insulin-like growth factor 1 receptor expression in wild-type GISTs: a potential novel therapeutic target.

scientific article published in December 2009

Insulin-like growth factor 2 mRNA-binding protein 3 is a novel post-transcriptional regulator of Ewing sarcoma malignancy.

scientific article published on 27 April 2018

Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma.

scientific article published on September 2006

Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma

scientific article published on 13 December 2021

Integrated approaches to miRNAs target definition: time-series analysis in an osteosarcoma differentiative model.

scientific article published on 30 June 2015

Irinotecan and temozolomide in recurrent Ewing sarcoma: an analysis in 51 adult and pediatric patients.

scientific article published on 13 March 2018

Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines.

scientific article

Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug

scientific article (publication date: 2013)

MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.

scientific article published on 13 May 2015

Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators.

scientific article

Multidrug resistance and malignancy in human osteosarcoma

scientific article published on 01 May 1996

Multidrug-resistance (MDR) phenotype of human osteosarcoma cells evaluated by quantitative morphological and electron microscopy analyses.

scientific article published on January 1995

Myogenic differentiation of human rhabdomyosarcoma cells induced in vitro by antineoplastic drugs

scientific article published on 01 July 1989

NVP-BEZ235 as a new therapeutic option for sarcomas.

scientific article

New model for bone resorption study in vitro: human osteoclast-like cells from giant cell tumors of bone.

scientific article

Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy.

scientific article

Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma

scientific article published in August 2008

Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome

scientific article published on 23 March 2009

Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma

scientific article published on 17 February 2021

Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin

scientific article published on 01 July 1994

Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines.

scientific article published on 13 May 2015

Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma

scientific article published on February 2007

Prelamin A is involved in early steps of muscle differentiation.

scientific article

Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle.

scientific article published on 11 February 2011

Process development of a human recombinant diabody expressed in E. coli: engagement of CD99-induced apoptosis for target therapy in Ewing's sarcoma.

scientific article published on 21 December 2015

Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma

scientific article

Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression.

scientific article published on 10 July 2014

Prognostic value of CCN3 in osteosarcoma

scientific article published on February 2008

Redundancy of autocrine loops in human osteosarcoma cells.

scientific article published on February 1999

Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction

scientific article published on 10 October 2008

Reprogramming Tumor-Immune Cell Interface in Solid and Hematological Malignancies to Enhance Response to Therapy.

scientific article published on 5 March 2018

Retinoic Acid Induces Cell Proliferation and Modulates Gelatinases Activity in Human Osteoclast-like Cell Lines

scientific article published on 01 October 1996

Simultaneous paired analysis of numerical chromosomal aberrations and DNA content in osteosarcoma.

scientific article published in July 2001

Sortilin regulates progranulin action in castration-resistant prostate cancer cells

scientific article

Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion.

scientific article published on 5 September 2012

Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma

scientific article published on 3 October 2014

Targeted therapies in bone sarcomas.

scientific article

Targeting CD99 in association with doxorubicin: an effective combined treatment for Ewing's sarcoma

scientific article published on 2 December 2005

Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy.

scientific article published on 20 January 2017

Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy.

scientific article published in January 2011

The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors

scientific article

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit

scientific article published on 01 February 1995

The expression of Met/hepatocyte growth factor receptor gene in giant cell tumors of bone and other benign musculoskeletal tumors

scientific article published on 01 August 2000

The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.

scientific article

The expression of ccn3(nov) gene in musculoskeletal tumors

scientific article published on March 2002

The first European interdisciplinary ewing sarcoma research summit ⬇️

scientific article

The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit

scientific article published in December 2000

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease

scientific article

Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

scientific article published on 9 June 2017

Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents.

scientific article

Treatment of nonmetastatic Ewing's sarcoma family tumors of the spine and sacrum: the experience from a single institution.

scientific article

Tumoral immune-infiltrate (IF), PD-L1 expression and role of CD8/TIA-1 lymphocytes in localized osteosarcoma patients treated within protocol ISG-OS1.

scientific article published on 4 December 2017

Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities

scientific article

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

scientific article published on April 2012

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