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List of works by Birgit Geoerger

A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas

scientific article published on 22 November 2019

A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors

scientific article

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

scientific article published on 10 September 2019

A comparative analysis of paediatric dose-finding trials of molecularly targeted agent with adults' trials.

scientific article published on 27 March 2013

A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.

scientific article published on 3 December 2014

A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors

scientific article

A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: an Innovative Therapies for Children with Cancer (ITCC) study

scientific article published on 24 November 2011

A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study

scientific article published on 04 March 2013

A phase II study of irinotecan in children with relapsed or refractory neuroblastoma: a European cooperation of the Société Française d'Oncologie Pédiatrique (SFOP) and the United Kingdom Children Cancer Study Group (UKCCSG).

scientific article

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Euro

scientific article published on 12 June 2017

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma

scientific article published on 09 July 2020

Angiogenesis as a target in neuroblastoma.

scientific article published on 07 July 2008

Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

scientific article published on 28 June 2010

Atezolizumab for children and young adults with previously treated solid tumours, non-Hodgkin lymphoma, and Hodgkin lymphoma (iMATRIX): a multicentre phase 1-2 study

scientific article published on 25 November 2019

Bone sarcomas: from biology to targeted therapies.

scientific article published on 27 November 2012

Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.

scientific article

Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia

scientific article published on 27 March 2020

Do medulloblastoma tumors meet the Food and Drug Administration criteria for anti-erbB2 therapy with trastuzumab?

scientific article published in January 2008

Dose-finding designs in pediatric phase I clinical trials: Comparison by simulations in a realistic timeline framework ⬇️

scientific article published on April 13, 2012

Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors

scientific article published on 6 December 2016

EGFR inhibition using gefitinib is not active in neuroblastoma cell lines.

scientific article published in April 2009

EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts

scientific article published in July 2008

EPT-01DOSE-FINDING STUDY OF VINBLASTINE IN COMBINATION WITH NILOTINIB IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH REFRACTORY OR RECURRENT LOW-GRADE GLIOMA: RESULTS OF THE ITCC/SIOPE-BRAIN VINILO PHASE I TRIAL (NCT01887522).

scientific article published on 30 May 2016

EPT-07PARTICIPATION OF CHILDREN AND ADOLESCENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN PHASE I TRIALS WITHIN THE ITCC EUROPEAN CONSORTIUM.

scientific article published on 30 May 2016

EPT-13RAPIRI I – PHASE I STUDY OF DAILY ORAL RAPAMYCIN AND INTRAVENOUS IRINOTECAN IN CHILDREN WITH A RECURRENT/REFRACTORY MALIGNANT SOLID TUMOR: GOOD TOLERANCE AND PROMISING RESULTS IN BRAIN TUMORS - A REPORT FROM THE SOCIÉTÉ FRANÇAISE DES CANCERS E

scientific article

Early phase clinical trials of anticancer agents in children and adolescents - an ITCC perspective

scientific article

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

scientific article published on 01 December 2019

Efficacy of nivolumab in a patient with systemic refractory ALK+ anaplastic large cell lymphoma

scientific article published on 28 November 2017

Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice

scientific article published on 23 February 2018

Establishment and characterization of new orthotopic and metastatic neuroblastoma models

scientific article

Expression of p53, or targeting towards EGFR, enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma

scientific article published in May 2005

From class waivers to precision medicine in paediatric oncology.

scientific article published in July 2017

Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma

scientific article

HG-44EVALUATION OF ABT-414 IN CHILDREN WITH HIGH GRADE GLIOMA (HGG) AND DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG).

scientific article published on 30 May 2016

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

scientific article

High levels of circulating VEGFR2+ Bone marrow-derived progenitor cells correlate with metastatic disease in patients with pediatric solid malignancies

scientific article published in July 2009

IL10RA Modulates Crizotinib Sensitivity in NPM1-ALK-positive Anaplastic Large Cell Lymphoma

scientific article published on 23 June 2020

Immunodynamics of explanted human tumors for immuno-oncology

scientific article published on 29 December 2020

Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium

scientific article published on 09 October 2020

Implementation of mechanism of action biology-driven early drug development for children with cancer.

scientific article published on 31 May 2016

In-Vitro and In-Vivo Establishment and Characterization of Bioluminescent Orthotopic Chemotherapy-Resistant Human Osteosarcoma Models in NSG Mice

scientific article published on 17 July 2019

Indications and current development of new targeted therapies in pediatric oncology ⬇️

scientific article published on May 1, 2011

Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors

scientific article

Innovations for phase I dose-finding designs in pediatric oncology clinical trials.

scientific article published on 26 January 2016

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

scientific article

Integrated analysis of long-term growth and bone development in pediatric and adolescent patients receiving bevacizumab

scientific article published on 30 October 2018

Is the European pediatric medicine regulation working for children and adolescents with cancer?

scientific article published on 17 January 2013

LGG-46. TRAMETINIB THERAPY IN PEDIATRIC PATIENTS WITH LOW-GRADE GLIOMAS (LGG) WITH BRAF GENE FUSION; A DISEASE-SPECIFIC COHORT IN THE FIRST PEDIATRIC TESTING OF TRAMETINIB

Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials

scientific article published on 24 February 2020

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas

scientific article

Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial

scientific article

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

scientific article

Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab

scientific article published in 2023

New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future

scientific article published on July 2010

Oncolytic activity of p53-expressing conditionally replicative adenovirus AdDelta24-p53 against human malignant glioma

scientific article published on August 2004

Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts.

scientific article published in February 2002

Open-label, multicentre, randomised, phase II study of the EpSSG and the ITCC evaluating the addition of bevacizumab to chemotherapy in childhood and adolescent patients with metastatic soft tissue sarcoma (the BERNIE study).

scientific article

Outcome of children and adolescents with central nervous system tumors in phase I trials.

scientific article published on 13 December 2017

Outcome of children with relapsed or refractory neuroblastoma: A meta-analysis of ITCC/SIOPEN European phase II clinical trials

scientific article published on 24 August 2016

Outcomes of metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated within the BERNIE study: a randomised, phase II study evaluating the addition of bevacizumab to chemotherapy

scientific article published on 13 March 2020

PDCT-02. EVALUATION OF DEPATUXIZUMAB MAFODOTIN (ABT-414) IN CHILDREN WITH HIGH GRADE GLIOMA (HGG) AND DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Parents' and children's comprehension and decision in a paediatric early phase oncology trial: a prospective study

scientific article published on 24 November 2018

Patients in pediatric phase I and early phase II clinical oncology trials at Gustave Roussy: a 13-year center experience

scientific article

Phase 1 study of dalotuzumab monotherapy and ridaforolimus-dalotuzumab combination therapy in paediatric patients with advanced solid tumours

scientific article published on 10 May 2016

Phase I results of a phase I/II study of weekly nab-paclitaxel in paediatric patients with recurrent/refractory solid tumours: A collaboration with innovative therapies for children with cancer

scientific article published on 21 June 2018

Phase I study of non-pegylated liposomal doxorubicin in children with recurrent/refractory high-grade glioma

scientific article

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma

scientific article published on 9 June 2017

Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours

scientific article

Phase I study of vinblastine in combination with nilotinib in children, adolescents, and young adults with refractory or recurrent low-grade glioma

scientific article published on 01 January 2020

Phase I study of weekly oxaliplatin in relapsed or refractory pediatric solid malignancies

scientific article

Phase II study of gemcitabine combined with oxaliplatin in relapsed or refractory paediatric solid malignancies: An innovative therapy for children with Cancer European Consortium Study

scientific article

Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma.

scientific article published on 26 October 2017

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

scientific article

Phase II study of temozolomide and topotecan (TOTEM) in children with relapsed or refractory extracranial and central nervous system tumors including medulloblastoma with post hoc Bayesian analysis: A European ITCC study

scientific article published on 08 October 2019

Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: a European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study.

scientific article

Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour: good tolerance profile and efficacy in rhabdomyosarcoma--a report from the Société Française d

scientific article published on 25 May 2012

Phase II trial of irinotecan in children with relapsed or refractory rhabdomyosarcoma: a joint study of the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group

scientific article

Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma

scientific article

Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies

scientific article published in February 2016

Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.

scientific article published on 8 June 2011

Population pharmacokinetics and pharmacogenetics of imatinib in children and adults.

scientific article

Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.

scientific article published in October 2002

Precision medicine at its best: Prolonged survival in a child presenting a secondary mesothelioma treated with crizotinib

scientific article published on 08 September 2020

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma

scientific article published on 21 December 2014

Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma

scientific article published on 24 October 2011

Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study.

scientific article published on 20 September 2016

Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models

scientific article

Revisiting the definition of dose-limiting toxicities in paediatric oncology phase I clinical trials: An analysis from the Innovative Therapies for Children with Cancer Consortium

scientific article

SFCE-RAPIRI Phase I Study of Rapamycin Plus Irinotecan: A New Way to Target Intra-Tumor Hypoxia in Pediatric Refractory Cancers

scientific article published on 20 October 2020

Sequential or combined designs for Phase I/II clinical trials? A simulation study

scientific article published on 20 September 2019

Small molecule tyrosine kinase inhibitors: potential role in pediatric malignant solid tumors

scientific article published on February 2008

Stereotactic biopsy of diffuse pontine lesions in children

scientific article

Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium.

scientific article

Targeting the EWSR1-FLI1 oncogene-induced protein kinase PKC-β abolishes ewing sarcoma growth

scientific article published on 28 August 2012

The role of the 'innovative therapies for children with cancer' (ITCC) European consortium.

scientific article published on 15 March 2010

The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts.

scientific article

Unmet needs for relapsed or refractory Wilms tumour: Mapping the molecular features, exploring organoids and designing early phase trials - A collaborative SIOP-RTSG, COG and ITCC session at the first SIOPE meeting

scientific article published on 17 December 2020

Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.

scientific article

[Conditionally replicative adenoviruses: a second wind for cancer gene therapy]

scientific article published on 01 December 2003

p53 Pathway dysfunction in primary childhood ependymomas

scientific article

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