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List of works by Douglas R Spitz

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress.

scientific article published on 28 November 2007

2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines ⬇️

scientific article published on October 10, 2011

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality

scientific article published on 19 February 2018

A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11)

scientific article published on 31 August 2013

A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats.

scientific article published in August 2000

A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media

scientific article published on 01 June 2000

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.

scientific article

Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status.

scientific article

All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB.

scientific article

Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells.

scientific article published on February 2006

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.

scientific article published on 02 August 2011

Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide.

scientific article

Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats

scientific article published on 01 July 1998

Assay of superoxide dismutase activity in tumor tissue

scientific article published on 01 January 1984

Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.

scientific article published on 11 March 2016

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

scientific article published on 26 August 2017

Bcl-2 and Bcl-xL in peroxide-resistant A549 and U87MG cells

scientific article published on 01 April 1998

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.

scientific article

Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.

scientific article

Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair

scientific article published on 17 August 2006

Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers

scientific article published on 24 July 2013

Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation.

scientific article published on December 2000

Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung

scientific article

Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.

scientific article published on 14 November 2008

Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism

scientific article

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

scientific article

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials.

scientific article

Contribution of mitochondrial DNA repair to cell resistance from oxidative stress.

scientific article

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87]

scientific article published on 08 June 2018

D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress.

scientific article published on 5 April 2017

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.

scientific article published on 12 January 2012

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).

scientific article published on 27 July 2008

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.

scientific article published on 3 April 2018

Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis

scientific article

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.

scientific article published on 8 June 2010

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

scientific article published on 18 June 2015

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

scientific article published on 10 February 2020

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

scientific article

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

scientific article published on 31 August 2018

Enhanced γ-Glutamyl Transpeptidase Expression and Selective Loss of CuZn Superoxide Dismutase in Hepatic Iron Overload

scientific article published on 01 March 1998

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

scientific article published on 19 September 2016

Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

scientific article

Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.

scientific article published on 11 April 2011

Essential Components of Cancer Education

scientific article

Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice.

scientific article published in May 2003

Evidence that hydrogen peroxide generated by 365-nm UVA radiation is not important in mammalian cell killing.

scientific article published on August 1990

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity ⬇️

scientific article published on June 23, 2012

Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent

scientific article published on 01 May 1997

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

scientific article published on 19 October 2011

Glial cell type-specific responses to menadione-induced oxidative stress

scientific article published on 01 April 2000

Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.

scientific article

Glutaminase inhibitors induce thiol-mediated oxidative stress and radio-sensitization in treatment resistant cervical cancers

scientific article published on 21 October 2020

Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal ⬇️

scientific article published on January 1, 1991

Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts.

scientific article published on June 1997

High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide

scientific article published on 01 October 1996

Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells.

scientific article published on July 2008

Hyperbilirubinemia results in reduced oxidative injury in neonatal gunn rats exposed to hyperoxia

scientific article published on 01 October 1995

Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells.

scientific article published on August 1992

In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine

scientific article published on 01 January 1996

Inactivation of anthracyclines by cellular peroxidase.

scientific article published on July 2005

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

scientific article published on July 2006

Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil

scientific article published on 01 May 1998

Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth

scientific article published on 28 November 2007

Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress.

scientific article published on 15 December 2006

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

scientific article published on 7 July 2015

Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress ⬇️

scientific article published on January 19, 2012

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

scientific article published on February 2006

Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.

scientific article

Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine

scientific article published on 11 February 2014

James William Osborne, PhD 1928-2015.

scientific article published in February 2016

Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts ⬇️

scientific article published on 06 June 2013

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

scientific article

Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways

scientific article

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

scientific article published on 29 January 2015

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender

scientific article

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

scientific article

Mammalian resistance to oxidative stress: a comparative analysis.

scientific article published in January 2002

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.

scientific article

Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses

scientific article

Manipulation of cellular redox parameters for improving therapeutic responses in B‐cell lymphoma and multiple myeloma ⬇️

scientific article published on February 1, 2012

Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives

scientific article published on 01 January 1999

Mechanisms of H2O2-induced oxidative stress in endothelial cells.

scientific article published on 23 March 2006

Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: The significance of increased catalase activity in H2O2-resistant fibroblasts ⬇️

scientific article published on January 1, 1992

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

scientific article published on August 2004

Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells.

scientific article published on February 1999

Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation

scientific journal article

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

scientific article

Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.

scientific article published on 8 December 2011

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.

scientific article published in August 2017

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival

scientific article

Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.

scientific article published on 13 October 2006

Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

scientific article

Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction

scientific article published on November 2005

Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.

scientific article published in May 2005

Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells.

scientific article published on April 2007

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

scientific article

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

article

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth.

scientific article published on 4 May 2006

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.

scientific article published on 13 November 2011

Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

scientific article

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

scientific article

Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma

scientific article published on 16 March 2018

Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle.

scientific article

Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure.

scientific article published on 28 September 2009

Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy

scientific article published on 31 December 2007

Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.

scientific article published on 12 March 2004

Radio-resistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism

scientific article published on 16 January 2018

Radiofrequency electromagnetic fields have no effect on the in vivo proliferation of the 9L brain tumor.

scientific article published in December 1999

Reactive oxygen species in normal and tumor stem cells.

scientific article

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

scientific article

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid

scientific article

Redox control of cell cycle-coupled topoisomerase II alpha gene expression

scientific article published on 01 January 2002

Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock.

scientific article published on June 1999

Redox signaling in cancer biology.

scientific article published in July 2006

Regulation of normal cell cycle progression by flavin-containing oxidases.

scientific article

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population

scientific article

Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2.

scientific article

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

scientific article

Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes.

scientific article published on 11 June 2013

Sensitivity to Low-Dose/Low-LET Ionizing Radiation in Mammalian Cells Harboring Mutations in Succinate Dehydrogenase Subunit C is Governed by Mitochondria-Derived Reactive Oxygen Species ⬇️

scientific article published on November 17, 2010

Serial changes in tumor oxygenation during the early phase of radiation therapy in cervical cancer—are we quantitating hypoxia change? re: Lyng et al., IJROBP 2000; 46:935–946

article

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.

scientific article published on 4 November 2011

Sirt3, mitochondrial ROS, ageing, and carcinogenesis.

scientific article

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

scientific article published on December 2010

Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

scientific article published on 24 February 2016

Stable H2O2-resistant variants of Chinese hamster fibroblasts demonstrate increases in catalase activity.

scientific article

Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats.

scientific article published on 21 June 2009

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

scientific article

Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer.

scientific article

Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3.

scientific article published on 28 September 2013

Superoxide mediates the actions of angiotensin II in the central nervous system.

scientific article published in November 2002

Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism

scientific article

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

scientific article published on 01 July 2018

The Absence of CpG in Plasmid DNA–Chitosan Polyplexes Enhances Transfection Efficiencies and Reduces Inflammatory Responses in Murine Lungs

scientific article (publication date: 20 January 2014)

The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells

scientific article published on September 1, 1992

The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.

scientific article published on 17 January 2011

The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion.

scientific article

Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress.

scientific article published on 11 August 2005

Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.

scientific article published on September 2010

Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress.

scientific article published on July 2004

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

scientific article published on 18 September 2008

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