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List of works by Martine Jandrot-Perrus

A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents.

scientific article

A new macromolecular paramagnetic MR contrast agent binds to activated human platelets

scientific article published in July 2007

A paradoxical pro-apoptotic effect of thrombin on smooth muscle cells

article

ADP-induced platelet aggregation depends on the conformation or availability of the terminal gamma chain sequence of fibrinogen. Study of the reactivity of fibrinogen Paris 1

scientific article published on 01 August 1987

Abacavir has no prothrombotic effect on platelets in vitro.

scientific article published on 11 August 2016

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations

scientific article published on 23 June 2009

Activation state of platelets in experimental severe hemophilia A.

scientific article published on 14 March 2012

Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1

scientific article published on 01 October 1997

Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets

scientific article

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke.

scientific article published on 6 October 2015

Amino-Fucoidan as a Vector for rtPA-Induced Fibrinolysis in Experimental Thrombotic Events

scientific article published on 5 January 2018

An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis.

scientific article published on 6 July 2009

An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation

scientific article published on 01 September 1994

Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.

scientific article

Anticoagulant activity of a dermatan sulfate from the skin of the shark Scyliorhinus canicula

scientific article published in September 2010

Anticoagulant and antithrombotic properties of platelet protease nexin-1

scientific article

Atorvastatin limits the pro-inflammatory response of rat aortic smooth muscle cells to thrombin.

scientific article published in August 2003

Binding of heparin to platelet membrane glycoprotein Ib: functional effects

scientific article published on 01 February 1999

Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro

scientific article published on 29 December 2016

Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: characterization and mechanism of thrombin inhibition

scientific article published on 01 October 1993

Bothrojaracin: a potent two-site-directed thrombin inhibitor

scientific article published on 01 July 1996

Characteristics of the interaction between thrombin exosite 1 and the sequence 269-287 [correction of 269-297] of platelet glycoprotein Ibalpha

scientific article published on 01 August 1998

Characterization of a novel dermatan sulfate with high antithrombin activity from ray skin (Raja radula).

scientific article published on 20 November 2008

Chimeric Fc Receptors Identify Ligand Binding Regions in Human Glycoprotein VI

scientific article published on 07 July 2006

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

scientific article (publication date: September 2000)

Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI.

scientific article

Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions

scientific article published on 12 February 2005

Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa

scientific article published on 01 January 1998

Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.

scientific article

Covalent binding of human thrombin to a human endothelial cell-associated protein

scientific article published on 01 March 1989

Cross-linking of alpha and gamma-thrombin to distinct binding sites on human platelets

scientific article published on 01 June 1988

Defective collagen-induced platelet activation in two patients with malignant haemopathies is related to a defect in the GPVI-coupled signalling pathway

scientific article published on 01 January 2005

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

scientific article

Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

scientific article published on 11 January 2010

Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro

scientific article published on 25 June 2009

Design and reshaping of an scFv directed against human platelet glycoprotein VI with diagnostic potential

scientific article published on 02 July 2011

Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks

scientific article

Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes

scientific article published on 20 July 2004

Dilation-Dependent Activation of Platelets and Prothrombin in Human Thoracic Ascending Aortic Aneurysm

scientific article published in May 2008

Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.

scientific article published on 21 July 2009

Effect of phosphopyridoxylation on thrombin interaction with platelet glycoprotein Ib

scientific article published on 01 August 1991

Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets

scientific article published on 01 September 1991

Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.

scientific article published on 10 January 2012

Endothelial Protease Nexin-1 Is a Novel Regulator of A Disintegrin and Metalloproteinase 17 Maturation and Endothelial Protein C Receptor Shedding via Furin Inhibition ⬇️

scientific article published on May 9, 2013

Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: a possible involvement of thrombin.

scientific article published in March 1993

Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression

scientific article published on 14 April 2008

Exacerbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transformation.

scientific article published on 19 May 2017

Exploring the platelet proteome via combinatorial, hexapeptide ligand libraries

scientific article

Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

scientific article

Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity.

scientific article published on 6 August 2015

Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin

scientific article published on 01 July 2005

Fibrinogen Bondy: a new case of dysfibrinogenemia. Isolation of the abnormal fibrinogen molecules

scientific article published on 01 September 1982

Gamma-thrombin-induced phospholipase A2 activation in rabbit platelets: comparison with alpha-thrombin

scientific article published on 01 September 1989

Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin.

scientific article published in July 2003

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

scientific article

Heterogeneity of platelet functional alterations in patients with filamin A mutations.

scientific article

Highly sulfated dermatan sulfate from the skin of the ray Raja montagui: anticoagulant activity and mechanism of action

scientific article published in July 2010

Human gamma-thrombin: lack of correlation between a platelet functional response and glycoprotein V hydrolysis

scientific article published on 01 October 1987

Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments

scientific article published on 01 December 2003

Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.

scientific article published on 4 October 2004

In vitro and in vivo antiangiogenic properties of the serpin protease nexin-1

scientific article published on 13 February 2012

Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression

scientific article published on 8 September 2014

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan

scientific article published on 8 June 2015

Inhibition of thrombin-catalyzed factor V activation by bothrojaracin

scientific article published on 01 June 1998

Late-fibrin(ogen) fragment E modulates human alpha-thrombin specificity

scientific article published on 01 July 1993

Macrophages and Platelets Are the Major Source of Protease Nexin-1 in Human Atherosclerotic Plaque

scientific article published on 10 July 2008

Mechanism of thrombin inhibition by heparin cofactor II and antithrombin in the presence of the ray (Raja radula) skin dermatan sulfate

scientific article published on 28 November 2008

Modulation of protease nexin-1 activity by polysaccharides

scientific article published in February 2006

Molecular Cloning and Expression of Bothrojaracin, A Potent Thrombin Inhibitor from Snake Venom

scientific article published on 01 September 1997

Monocytes downregulate the early stage of collagen-induced platelet activation by a PECAM-1-dependent mechanism

scientific article published in January 2009

Myoblast fusion promotes the appearance of active protease nexin I on human muscle cell surfaces

scientific article published on 01 January 1996

New advances in treating thrombotic diseases: GPVI as a platelet drug target

scientific article

Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VI

scientific article published on 18 May 2009

Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen

scientific article published on 01 April 1999

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

scientific article

Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

scientific article published in March 2012

Platelet Protease Nexin-1, a Serpin That Strongly Influences Fibrinolysis and Thrombolysis ⬇️

scientific article published on March 14, 2011

Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis.

scientific article published on April 2015

Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen

scientific article published on 31 August 2004

Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen-Induced Platelet Aggregation

scientific article published on 04 June 2020

Protease nexin I expression is up-regulated in human skeletal muscle by injury-related factors

scientific article published on 01 June 1999

Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect

scientific article

Protease nexin-1 regulates retinal vascular development

article

Protease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells

scientific journal article

Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections

scientific article published on 4 November 2017

Protease-activating Receptor-4 Induces Full Platelet Spreading on a Fibrinogen Matrix

scientific article published on 02 January 2007

Proteolytic derivatives of thrombin

scientific article published on 01 January 1986

Radiolabeled fucoidan as a p-selectin targeting agent for in vivo imaging of platelet-rich thrombus and endothelial activation

scientific article published on 17 August 2011

Role of the thrombin insertion loop 144-155. Study of thrombin mutations W148G, K154E and a thrombin-based synthetic peptide

scientific article published on 01 April 1995

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation

scientific journal article

Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke

scientific article published on 31 August 2020

Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome.

scientific article published on 9 March 2004

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice.

scientific article

Smad2-dependent protease nexin-1 overexpression differentiates chronic aneurysms from acute dissections of human ascending aorta.

scientific article published on 27 June 2013

Studies of platelet fibrinogen from a subject with a congenital plasma fibrinogen abnormality (fibrinogen Paris I) ⬇️

scientific article published on November 1, 1979

Studies on the megakaryocytes of a patient with the Bernard-Soulier syndrome

scientific article published on 01 December 1990

Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.

scientific article

The Serpin Protease-Nexin 1 Is Present in Rat Aortic Smooth Muscle Cells and Is Upregulated in l -NAME Hypertensive Rats

scientific article published on 01 January 2003

The common pathway for alpha- and gamma-thrombin-induced platelet activation is independent of GPIb: a study of Bernard-Soulier platelets

scientific article published on 01 July 1990

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

scientific article

The future of glycoprotein VI as an antithrombotic target.

scientific article published on December 2012

The serpin protease nexin-1 regulates vascular smooth muscle cell adhesion, spreading, migration and response to thrombin.

scientific article published in February 2006

Thrombin Binding to Platelet Membrane Glycoprotein Ib ⬇️

scientific article published on January 1, 1992

Thrombin Metz: characterization of the dysfunctional thrombin derived from a variant of human prothrombin

scientific article published on 01 April 1984

Thrombin downregulates muscle acetylcholine receptors via an IP3 signaling pathway by activating its G-protein-coupled protease-activated receptor-1.

scientific article published in July 2003

Thrombin induces endothelin expression in arterial smooth muscle cells

scientific article published on 01 May 2000

Thrombin interaction with a recombinant N-terminal extracellular domain of the thrombin receptor in an acellular system.

scientific article published on January 1995

Thrombin interaction with platelet glycoprotein Ib: effect of glycocalicin on thrombin specificity ⬇️

scientific article published on December 1, 1992

Thrombin interaction with platelet membrane glycoprotein Ib alpha.

scientific article published in November 2003

Thrombin receptor induction by injury-related factors in human skeletal muscle cells.

scientific article

Thrombin reduces MuSK and acetylcholine receptor expression along with neuromuscular contact size in vitro.

scientific article published in April 2004

Thrombin specificity

scientific article published on 01 July 1995

[Antithrombotic recombinant antibodies]

scientific article published on 01 January 2006

[From platelet functions to therapy]

scientific article published on 05 November 2010

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