List of works - Motoko Takahashi

A Defect in the Mitochondrial Import of Mutant Mn-Superoxide Dismutase Produced in Sf21 Cells ⬇️

scientific article published on August 1, 1998

A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.

scientific article published on 4 December 2013

A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells.

scientific article

A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes ⬇️

scientific article published on February 1, 2001

A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase.

scientific article published on December 2006

Acrolein induces Hsp72 via both PKCdelta/JNK and calcium signaling pathways in human umbilical vein endothelial cells.

scientific article published in May 2005

Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.

scientific article published on 15 March 2007

Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE

scientific article published on 01 December 2000

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice

scientific article

Beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.

scientific article published on 23 October 2003

Cloning of amadoriase I isoenzyme from Aspergillus sp.: evidence of FAD covalently linked to Cys342.

scientific article

Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins.

scientific article published on 04 May 2009

Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.

scientific article published on 11 March 2009

Disease-associated glycans on cell surface proteins.

scientific article published on 27 April 2016

Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells.

scientific article

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

scientific journal article

Elevation of aldose reductase gene expression in rat primary hepatoma and hepatoma cell lines: implication in detoxification of cytotoxic aldehydes

scientific article published on 01 September 1995

Fragmentation of ceruloplasmin following non-enzymatic glycation reaction

scientific article published on 01 November 1995

Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease.

scientific article published on 20 July 2015

Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes

scientific article published on 26 October 2007

Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites

scientific article published on 01 October 1994

Glycation vs. glycosylation: a tale of two different chemistries and biology in Alzheimer's disease.

scientific article published on 21 June 2016

Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185.

scientific article published in February 2003

In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites

scientific article

In vivo role of aldehyde reductase.

scientific article

Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.

scientific article published on 26 February 2007

Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.

scientific article

Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus sp

scientific article published on 01 February 1997

Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in Fut8-/- mice

scientific article published on 01 March 2006

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

scientific article published on 12 May 2018

Mutational analysis of Cys(88) of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.

scientific article

N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion.

scientific article published on 6 November 2007

N-glycans of growth factor receptors: their role in receptor function and disease implications.

scientific article published on October 2016

N-glycosylation regulates MET processing and signaling

scientific article published on 13 February 2022

Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells

scientific journal article

Overexpression of N-acetylglucosaminyltransferase III enhances the epidermal growth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors.

scientific article

Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change.

scientific article published on 29 September 2004

Proteomic and glycomic analyses of a lung-specific protein surfactant protein-D.

scientific article

Pulmonary Collectins Play Distinct Roles in Host Defense against Mycobacterium avium ⬇️

scientific article published on August 5, 2011

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.

scientific article

Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogene

scientific article

Selective suppression of IgG2a subclass in LEC rats during development

scientific article published on 01 August 1994

Suppression of heregulin β signaling by the single N-glycan deletion mutant of soluble ErbB3 protein.

scientific article published on 4 October 2013

Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection

scientific article published on 22 February 2017

The Asn418-linked N-glycan of ErbB3 plays a crucial role in preventing spontaneous heterodimerization and tumor promotion

scientific article published on 01 March 2007

The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue

scientific article

The internalization and metabolism of 3-deoxyglucosone in human umbilical vein endothelial cells.

scientific article

The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway.

scientific article published on 24 October 2014

List of works by Motoko Takahashi

A Defect in the Mitochondrial Import of Mutant Mn-Superoxide Dismutase Produced in Sf21 Cells ⬇️

A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.

A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells.

A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes ⬇️

A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase.

Acrolein induces Hsp72 via both PKCdelta/JNK and calcium signaling pathways in human umbilical vein endothelial cells.

Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.

Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice

Beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.

Cloning of amadoriase I isoenzyme from Aspergillus sp.: evidence of FAD covalently linked to Cys342.

Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins.

Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.

Disease-associated glycans on cell surface proteins.

Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells.

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

Elevation of aldose reductase gene expression in rat primary hepatoma and hepatoma cell lines: implication in detoxification of cytotoxic aldehydes

Fragmentation of ceruloplasmin following non-enzymatic glycation reaction

Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease.

Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes

Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites

Glycation vs. glycosylation: a tale of two different chemistries and biology in Alzheimer's disease.

Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185.

In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites

In vivo role of aldehyde reductase.

Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.

Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.

Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus sp

Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in Fut8-/- mice

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Mutational analysis of Cys(88) of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.

N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion.

N-glycans of growth factor receptors: their role in receptor function and disease implications.

N-glycosylation regulates MET processing and signaling

Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells

Overexpression of N-acetylglucosaminyltransferase III enhances the epidermal growth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors.

Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change.

Proteomic and glycomic analyses of a lung-specific protein surfactant protein-D.

Pulmonary Collectins Play Distinct Roles in Host Defense against Mycobacterium avium ⬇️

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.

Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogene

Selective suppression of IgG2a subclass in LEC rats during development

Suppression of heregulin β signaling by the single N-glycan deletion mutant of soluble ErbB3 protein.

Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection

The Asn418-linked N-glycan of ErbB3 plays a crucial role in preventing spontaneous heterodimerization and tumor promotion

The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue

The internalization and metabolism of 3-deoxyglucosone in human umbilical vein endothelial cells.

The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway.