Search filters

List of works by Carlo Napolitano

A Recessive Variant of the Romano-Ward Long-QT Syndrome? ⬇️

scientific article published on June 23, 1998

A newly characterized SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia.

scientific article published on April 2003

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

scientific article

Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin

scientific article (publication date: 5 March 2004)

Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia.

scientific article published on 06 October 2016

Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

scientific article published on 18 December 2017

Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry.

scientific article published in June 1998

Allele-Specific Silencing of Mutant mRNA Rescues Ultrastructural and Arrhythmic Phenotype in Mice Carriers of the R4496C Mutation in the Ryanodine Receptor Gene (RYR2).

scientific article published on 15 June 2017

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

scientific article published on 06 July 2006

Arrhythmogenic Right Ventricular Cardiomyopathy: Clinical Course and Predictors of Arrhythmic Risk.

scientific article published in December 2016

Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia

scientific article

Association of Hydroxychloroquine with QTc Interval in Patients with COVID-19

scientific article published on 05 June 2020

Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers.

scientific article published in September 2004

Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.

scientific article published on 12 May 2005

Bridging the dimensions of research on cardiac ryanodine receptor mutations.

scientific article

Brugada syndrome

scientific article (by Napolitano)

Brugada syndrome and sudden cardiac death in children

scientific article published on 01 March 2000

CARDIO-i2b2: integrating arrhythmogenic disease data in i2b2

scientific article published on January 1, 2012

Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

scientific journal article

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.

scientific article

Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.

scientific article

Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling

scientific article published on 21 June 2018

Cardiac Sodium Channel Diseases ⬇️

scientific article published on April 1, 2003

Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels.

scientific article

Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome

scientific article published in December 2005

Cardiac receptor activation and arrhythmogenesis.

scientific article

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

scientific article published in August 1999

Clinical Presentation and Outcome of Brugada Syndrome Diagnosed With the New 2013 Criteria

scientific article published on 21 April 2016

Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia.

scientific article

Clinical and research data integration: the i2b2-FSM experience

scientific article

Clinical implications for affected parents and siblings of probands with long-QT syndrome.

scientific article published in July 2001

Clinical implications for patients with long QT syndrome who experience a cardiac event during infancy

scientific article published in August 2009

Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome.

scientific article published in October 1999

Computer simulation of wild-type and mutant human cardiac Na+ current

scientific article published on March 2006

Concealed arrhythmogenic syndromes: the hidden substrate of idiopathic ventricular fibrillation?

scientific article

Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome

scientific article published on 01 June 1996

ESC-ERC recommendations for the use of automated external defibrillators (AEDs) in Europe.

scientific article published on March 2004

Early afterdepolarizations induced in vivo by reperfusion of ischemic myocardium. A possible mechanism for reperfusion arrhythmias

scientific article published on 01 June 1990

Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.

scientific article published in February 2000

Electrocardiographic Prediction of Abnormal Genotype in Congenital Long QT Syndrome: Experience in 101 Related Family Members

article

Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome.

scientific article published in February 2003

Evaluation of BLS-D training in lay people

scientific article published in July 2004

Evaluation of the spatial aspects of T-wave complexity in the long-QT syndrome

scientific article published on 01 November 1997

Experimental therapy of genetic arrhythmias: disease-specific pharmacology.

scientific article

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

scientific article (publication date: 27 June 2003)

Female predominance and transmission distortion in the long-QT syndrome.

scientific article published in December 2006

Fever-Related Arrhythmic Events in the Multicenter Survey on Arrhythmic Events in Brugada Syndrome (SABRUS).

scientific article published on 9 April 2018

Flecainide and antiarrhythmic effects in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

scientific article published on February 2012

Flecainide monotherapy for catecholaminergic polymorphic ventricular tachycardia: Perspectives and limitations

scientific article published on 21 October 2015

Flecainide test in Brugada syndrome: a reproducible but risky tool.

scientific article published in January 2003

From catheters to vectors: the dawn of molecular electrophysiology

scientific article published on 01 December 2000

From decision to shared-decision: Introducing patients' preferences into clinical decision analysis.

scientific article published in November 2014

Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients

scientific article published on 13 August 2007

Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients

scientific article published on 13 June 2018

Gene-Specific Therapy With Mexiletine Reduces Arrhythmic Events in Patients With Long QT Syndrome Type 3.

scientific article published in March 2016

Gene-specific differences in the circadian variation of ventricular repolarization in the long QT syndrome: a key to sudden death during sleep?

scientific article published in May 2000

Genetic modulators of the phenotype in the long QT syndrome: state of the art and clinical impact.

scientific article published on August 2015

Genetic risk stratification in cardiac arrhythmias

scientific article published on 01 May 2018

Genetic testing for inherited cardiac arrhythmias.

scientific article published on March 2010

Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice.

scientific article published in December 2005

Genetic testing of inherited arrhythmias.

scientific article published on 17 March 2012

Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype.

scientific article published on 2 May 2014

Genetics and arrhythmias: diagnostic and prognostic applications ⬇️

scientific article published on January 14, 2012

Genetics for the Electrophysiologist: Take Home Messages for the Clinician

scientific article

Genetics of ion-channel disorders.

scientific article published on May 2012

Genetics of ventricular tachycardia.

scientific article

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.

scientific article published in January 2001

Graphical representation of life paths to better convey results of decision models to patients.

scientific article published on 14 January 2015

High Efficacy of β-Blockers in Long-QT Syndrome Type 1

article by G. Michael Vincent et al published 20 January 2009 in Circulation

Homozygous deletion in KVLQT1 associated with Jervell and Lange-Nielsen syndrome.

scientific article published in March 1999

How Really Rare Are Rare Diseases?:

scientific article published in October 2003

Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome.

scientific article

Impact of molecular biology on diagnosis and management of arrhythmogenic disorders

scientific article published on 01 April 1998

In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes

article

In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves

scientific article

Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors.

scientific article

Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia

scientific article

Induced pluripotent stem cell-derived cardiomyocytes in studies of inherited arrhythmias

scientific article

Information extraction from Italian medical reports: An ontology-driven approach

scientific article published on 23 December 2017

Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes

scientific article published on 15 June 2001

Inherited arrhythmia syndromes: applying the molecular biology and genetic to the clinical management.

scientific article published on October 2003

Inherited calcium channelopathies in the pathophysiology of arrhythmias ⬇️

scientific article published on June 26, 2012

International Triadin Knockout Syndrome Registry

scientific article published on 01 February 2019

Interplay Between Genetic Substrate, QTc Duration, and Arrhythmia Risk in Patients With Long QT Syndrome

scientific article published on 01 April 2018

Intracellular calcium handling dysfunction and arrhythmogenesis: a new challenge for the electrophysiologist.

scientific article published in November 2005

J-Wave Syndromes: Electrocardiographic and Clinical Aspects

scientific article published on 01 June 2018

Just another Brugada syndrome mutation?

scientific article published on 17 November 2006

Late gadolinium enhancement by cardiovascular magnetic resonance is complementary to left ventricle ejection fraction in predicting prognosis of patients with stable coronary artery disease.

scientific article

Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome

scientific article published on 29 March 2004

Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome

scientific article published in November 2003

Long QT syndrome and pregnancy

scientific article published on 27 February 2007

Long QT syndrome and short QT syndrome: how to make correct diagnosis and what about eligibility for sports activity.

scientific article

Long QT syndrome in adults

scientific article published on 4 January 2007

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

scientific article published in December 1995

Long-QT syndrome after age 40.

scientific article published on 21 April 2008

Low penetrance in the long-QT syndrome: clinical impact

scientific article published on 01 February 1999

Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities.

scientific article published on 26 June 2009

Meandering pathway leading from genotyping to personalized management of long-QT syndrome

scientific article published on 28 March 2012

Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype

scientific article

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

scientific article published in July 2003

Molecular biology of the long QT syndrome: impact on management.

scientific article published in August 1997

Molecular diagnosis in a child with sudden infant death syndrome

scientific article published in The Lancet

Molecular underpinning of "good luck"

scientific article published on 01 August 2006

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.

scientific article published on 15 January 2010

Natural History and Risk Stratification in Andersen-Tawil Syndrome Type 1

scientific article published on 01 April 2020

Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes

scientific article

New-onset psychogenic seizures after surgery for epilepsy.

scientific article published in May 1998

Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.

scientific article published on April 2001

Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome.

scientific article published in October 2000

Novel insight into the natural history of short QT syndrome.

scientific article

Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality

scientific article published on 01 January 2011

Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

scientific article published on 18 June 2012

Pathogenesis and therapy of the idiopathic long QT syndrome

scientific article published on January 27, 1992

Patient-tailored workflow patterns from clinical practice guidelines recommendations

Policy Statement

scientific article published on 01 March 2004

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.

scientific article

Profile of Brugada Syndrome Patients Presenting with Their First Documented Arrhythmic Event. Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS).

scientific article published on 8 January 2018

Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis

scientific article published on 21 January 2016

Programmed electrical stimulation in Brugada syndrome: how reproducible are the results?

scientific article published on 01 September 2002

Reply: Did Mutation Type Affect the Efficacy of Mexiletine Observed in Patients With LQTS Type 3?

scientific article published on 01 January 2017

Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome

scientific article published on 21 April 2008

Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome

scientific article published in February 2011

Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals

scientific article published in January 2011

Risk of death in the long QT syndrome when a sibling has died

scientific article published on 4 March 2008

Risk stratification in Brugada syndrome: results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry.

scientific article published in January 2012

Risk stratification in the long-QT syndrome.

scientific article published in May 2003

Role of CACNA1C in Brugada syndrome: Prevalence and phenotype of probands referred for genetic testing

scientific article published in 2022

Role of calmodulin kinase in catecholaminergic polymorphic ventricular tachycardia ⬇️

scientific article published on March 10, 2011

Romano-Ward and other congenital long QT syndromes.

scientific article

RyRCa2+ Leak Limits Cardiac Ca2+ Window Current Overcoming the Tonic Effect of Calmodulin in Mice ⬇️

scientific article published on June 6, 2011

Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.

scientific article

Should patients with an asymptomatic Brugada electrocardiogram undergo pharmacological and electrophysiological testing?

scientific article

Significance of QT dispersion in the long QT syndrome.

scientific article

Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age.

scientific article published on 2 June 2014

Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes

scientific article published on 01 December 2000

Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.

scientific article published on 4 December 2013

Sudden cardiac death and genetic ion channelopathies: long QT, Brugada, short QT, catecholaminergic polymorphic ventricular tachycardia, and idiopathic ventricular fibrillation

scientific article published on 01 April 2012

Supervised methods to extract clinical events from cardiology reports in Italian

scientific article published on 28 May 2019

Supporting shared decision making within the MobiGuide project

scientific article

Sympathetic activation, ventricular repolarization and Ikr blockade: implications for the antifibrillatory efficacy of potassium channel blocking agents.

scientific article published in June 1995

The Elusive Link Between LQT3 and Brugada Syndrome

scientific article published on 01 August 2000

The Slow Pace of the Heart and the Objectives of Molecular Cardiology ⬇️

scientific article published on August 30, 2010

The contradictory genetics of atrial fibrillation: the growing gap between knowledge and clinical implications.

scientific article published in February 2013

The heritable nature of the electrocardiogram: How far can population genetics go?

scientific article published on 3 March 2009

The usual suspects in sudden cardiac death of the young: a focus on inherited arrhythmogenic diseases.

scientific article published on April 2014

Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

scientific article published on 01 May 2019

Torsade de pointes. Mechanisms and management.

scientific article

Transgenic models in cardiac arrhythmias: how close can we get to the bedside?

scientific article published on 01 February 2004

Unexpected Risk Profile of a Large Pediatric Population With Brugada Syndrome

scientific article published on 01 April 2019

Unusual retrospective prenatal findings in a male newborn with Timothy syndrome type 1.

scientific article published on 13 April 2015

Venice Chart international consensus document on atrial fibrillation ablation.

scientific article published on May 2007

When is genetic testing useful in patients suspected to have inherited cardiac arrhythmias?

scientific article published on January 2010

Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels ⬇️

scientific article published on November 12, 2010

Yield of genetic screening in inherited cardiac channelopathies: how to prioritize access to genetic testing.

scientific article published on 10 February 2009

[Brugada syndrome. Clinical, epidemiologic, and electrophysiologic features]

scientific article published on 01 December 1999

[Brugada's syndrome: epidemiology, risk stratification, and clinical management].

scientific article published in September 2002

[Molecular diagnosis in cardiology]

scientific article

[Role of standard resting ECG in the assessment of sudden cardiac death risk]

scientific article published on 01 December 2014

Paulina is supported by:

About Paulina

Help