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List of works by Lalage M Wakefield

A flexible reporter system for direct observation and isolation of cancer stem cells

scientific article

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis.

scientific article

A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland ⬇️

scientific article

A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.

scientific article

Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.

scientific article published in April 2007

Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism.

scientific article published on September 2008

An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer

scientific article

Beyond TGFβ: roles of other TGFβ superfamily members in cancer

scientific article published on May 2013

Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer

scientific article

Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

scientific article

Capillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnostics

scientific article

Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells

scientific article

Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines

scientific article

Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism

scientific article

Distribution and modulation of the cellular receptor for transforming growth factor-beta

scientific article

Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer

scientific article published on 09 January 2014

Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics

scientific article

Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects

scientific article

Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death.

scientific article

Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.

scientific article

Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-beta1 transcripts and their effect on translational efficiency.

scientific article published on September 1998

Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta

scientific article published on 01 May 1994

Isolation of a membrane protein by chromatofocusing: cytochrome b-561 of the adrenal chromaffin granule

scientific article published on 01 September 1984

Keeping order in the neighborhood: new roles for TGFbeta in maintaining epithelial homeostasis

scientific article published on 01 October 2007

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

scientific article

Modeling metastasis biology and therapy in real time in the mouse lung.

scientific article

Peptidylarginine deiminase IV (PADI4) regulates breast cancer stem cells via a novel tumor cell-autonomous suppressor role

scientific article published on 07 April 2020

Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3

scientific article published on 01 January 1990

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

scientific article published on 07 July 2009

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

scientific article

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium.

scientific article published on 17 May 2016

Recharacterization of the start sites for the major human transforming growth factor-beta 1 mRNA

scientific article published on 01 April 1997

Reconstitution of the Mg2+ -ATPase of the chromaffin granule membrane ⬇️

scientific article published on July 15, 1979

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.

scientific article published on 15 September 2016

SDF-1α mediates wound-promoted tumor growth in a syngeneic orthotopic mouse model of breast cancer.

scientific article

TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases

scientific article published on 01 August 1993

TGF-beta signaling in mammary gland development and tumorigenesis.

scientific article

TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

scientific article

TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury

scientific article

Tamoxifen and fenretinide in women with metastatic breast cancer

scientific article published on 01 October 1999

The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ

scientific article published on 03 October 2019

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

scientific article published on June 1996

The role of phospholipids in the modulation of enzyme activities in the chromaffin granule membrane

scientific article published on 01 May 1981

Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression

scientific article

Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models

scientific article

Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

scientific article published on September 2007

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

scientific article published in July 1998

Transforming growth factor-beta: biological function and chemical structure

scientific article

Transforming growth factor-beta: multifunctional regulator of cell growth and phenotype

scientific article published on 01 January 1988

Transforming growth factors-beta are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system.

scientific article

Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancer

scientific article (publication date: 2010)

Validation of transgenic mammary cancer models: goals of the NCI Mouse Models of Human Cancer Consortium and the mammary cancer CD-ROM

scientific article published on 01 December 2002

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