List of works - Orna Elroy-Stein

A Unique ISR Program Determines Cellular Responses to Chronic Stress.

scientific article published in December 2017

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter

article

A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells

scientific article published on 21 November 2008

A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression

scientific article

Analysis of hepatitis A virus translation in a T7 polymerase-expressing cell line.

scientific article published on January 1994

Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells

scientific article published on January 1992

Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue.

scientific article published on September 1994

Childhood ataxia with CNS hypomyelination/vanishing white matter disease--a common leukodystrophy caused by abnormal control of protein synthesis.

scientific article

Cleavage of the HIV replication primer tRNALys,3 in human cells expressing bacterial anticodon nuclease

scientific article

Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells

scientific article published on 21 August 2013

Diverse poly(A) binding proteins mediate internal translational initiation by a plant viral IRES.

scientific article

Does EBV RNA modulate ADA mRNA translation?

scientific article published in February 1998

Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy

scientific article published on 18 September 2018

Effect of Ku proteins on IRES-mediated translation

scientific article published on 01 June 2006

Gene expression using the vaccinia virus/ T7 RNA polymerase hybrid system.

scientific article

Genome-wide identification and quantification of protein synthesis in cultured cells and whole tissues by puromycin-associated nascent chain proteomics (PUNCH-P)

scientific article published on 06 March 2014

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

scientific article

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dismutase--implication for gene dosage effects in Down syndrome

scientific article published on 01 January 1988

Interaction of hnRNP-C1/C2 proteins with RNA: analysis using the yeast three-hybrid system

scientific article published on 01 July 2002

Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells

scientific article

Mitochondrial malfunction in vanishing white matter disease: a disease of the cytosolic translation machinery.

scientific article published in October 2017

Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.

scientific article published on 10 June 2011

Molecular genetics of Down's syndrome: overexpression of transfected human Cu/Zn-superoxide dismutase gene and the consequent physiological changes

scientific article published on 01 January 1986

Molecular structure and expression of the gene locus on chromosome 21 encoding the Cu/Zn superoxide dismutase and its relevance to Down syndrome

scientific article published on 01 January 1985

Monitoring Protein Synthesis in Living Cells with Fluorescent Labeled tRNA FRET Pairs.

scientific article published in May 2013

Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease

scientific article

New ways of initiating translation in eukaryotes.

scientific article published on December 2001

Novel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation.

scientific article published on 09 August 2013

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

scientific article published on 06 December 2021

Overexpression of human glucocerebrosidase containing different-sized leaders.

scientific article published on July 1996

Overexpression of the human CuZnSOD gene in transfected cells--implication to Down syndrome

scientific article published on 01 January 1987

PUNCH-P for global translatome profiling: Methodology, insights and comparison to other techniques.

scientific article

Phosphorylation of initiation factor-2 alpha is required for activation of internal translation initiation during cell differentiation.

scientific article published in June 2002

Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease

scientific article

Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis.

scientific article published on 29 April 2017

Proteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease.

scientific article published on 14 May 2015

Recurrent functional misinterpretation of RNA-seq data caused by sample-specific gene length bias

scientific article published on 12 November 2019

Regulation of mRNA Translation during cellular division.

scientific article published on 08 January 2008

Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription.

scientific article published in July 1998

Ribosomal slowdown mediates translational arrest during cellular division.

scientific article

Species-specific microRNA roles elucidated following astrocyte activation.

scientific article

The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation

scientific article

The glucocerebrosidase D409H mutation in Gaucher disease

scientific article published on 01 December 1996

The soluble form of two N-terminal domains of the poliovirus receptor is sufficient for blocking viral infection

scientific article published on September 1, 1992

Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.

scientific article

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome

scientific journal article

Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules.

scientific article published on December 1994

Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis

scientific article published on 6 October 2015

eIF2B Mutations Cause Mitochondrial Malfunction in Oligodendrocytes

scientific article published on 27 May 2019

List of works by Orna Elroy-Stein

A Unique ISR Program Determines Cellular Responses to Chronic Stress.

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter

A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells

A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression

Analysis of hepatitis A virus translation in a T7 polymerase-expressing cell line.

Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells

Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue.

Childhood ataxia with CNS hypomyelination/vanishing white matter disease--a common leukodystrophy caused by abnormal control of protein synthesis.

Cleavage of the HIV replication primer tRNALys,3 in human cells expressing bacterial anticodon nuclease

Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells

Diverse poly(A) binding proteins mediate internal translational initiation by a plant viral IRES.

Does EBV RNA modulate ADA mRNA translation?

Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy

Effect of Ku proteins on IRES-mediated translation

Gene expression using the vaccinia virus/ T7 RNA polymerase hybrid system.

Genome-wide identification and quantification of protein synthesis in cultured cells and whole tissues by puromycin-associated nascent chain proteomics (PUNCH-P)

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dismutase--implication for gene dosage effects in Down syndrome

Interaction of hnRNP-C1/C2 proteins with RNA: analysis using the yeast three-hybrid system

Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells

Mitochondrial malfunction in vanishing white matter disease: a disease of the cytosolic translation machinery.

Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.

Molecular genetics of Down's syndrome: overexpression of transfected human Cu/Zn-superoxide dismutase gene and the consequent physiological changes

Molecular structure and expression of the gene locus on chromosome 21 encoding the Cu/Zn superoxide dismutase and its relevance to Down syndrome

Monitoring Protein Synthesis in Living Cells with Fluorescent Labeled tRNA FRET Pairs.

Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease

New ways of initiating translation in eukaryotes.

Novel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation.

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

Overexpression of human glucocerebrosidase containing different-sized leaders.

Overexpression of the human CuZnSOD gene in transfected cells--implication to Down syndrome

PUNCH-P for global translatome profiling: Methodology, insights and comparison to other techniques.

Phosphorylation of initiation factor-2 alpha is required for activation of internal translation initiation during cell differentiation.

Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease

Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis.

Proteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease.

Recurrent functional misinterpretation of RNA-seq data caused by sample-specific gene length bias

Regulation of mRNA Translation during cellular division.

Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription.

Ribosomal slowdown mediates translational arrest during cellular division.

Species-specific microRNA roles elucidated following astrocyte activation.

The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation

The glucocerebrosidase D409H mutation in Gaucher disease

The soluble form of two N-terminal domains of the poliovirus receptor is sufficient for blocking viral infection

Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome

Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules.

Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis

eIF2B Mutations Cause Mitochondrial Malfunction in Oligodendrocytes