List of works - Alice Vrielink

A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase

scientific article

A missense mutation sheds light on a novel structure-function relationship of RANKL

scientific article published on 23 September 2020

A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein

scientific journal article

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

scientific article published on 14 March 2017

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

scientific article published on 18 January 2017

Atomic resolution density maps reveal secondary structure dependent differences in electronic distribution

scientific article

Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study.

scientific article

Biological channeling of a reactive intermediate in the bifunctional enzyme DmpFG.

scientific article published on 21 February 2012

Cholesterol oxidase: ultrahigh-resolution crystal structure and multipolar atom model-based analysis

scientific article

Cholesterol oxidases: a study of nature's approach to protein design

scientific article

Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol oxidase

scientific article

Computational site-directed mutagenesis studies of the role of the hydrophobic triad on substrate binding in cholesterol oxidase.

scientific article published on 15 May 2017

Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme-substrate recognition

scientific article published on 15 July 2021

Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes

scientific article

Crystal structure of LAAO from Calloselasma rhodostoma with an L-phenylalanine substrate: insights into structure and mechanism

scientific article

Crystallization and preliminary X-ray analysis of cholesterol oxidase from Brevibacterium sterolicum containing covalently bound FAD

scientific article published on 01 March 1996

Crystallization and preliminary X-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase--aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600.

scientific article

Crystallization and preliminary X-ray analysis of the formiminotransferase domain from the bifunctional enzyme formiminotransferase-cyclodeaminase

scientific article published on 01 June 1999

Crystallization and preliminary diffraction analysis of an engineered cephalosporin acylase.

scientific article published on 24 June 2010

Detergents in Membrane Protein Purification and Crystallisation.

scientific article

Direct demonstration of lipid phosphorylation in the lipid bilayer of the biomimetic bicontinuous cubic phase using the confined enzyme lipid A phosphoethanolamine transferase.

scientific article

Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase

scientific article

ESR and electron nuclear double resonance characterization of the cholesterol oxidase from Brevibacterium sterolicum in its semiquinone state.

scientific article published on June 1994

Editorial overview: Catalysis and regulation: Structural features guiding enzyme catalysed processes

scientific article published on 01 December 2018

Electron spin echo envelope modulation studies of the semiquinone anion radical of cholesterol oxidase from Brevibacterium sterolicum

scientific article published on 01 January 1997

Enzyme targets for drug design of new anti-virulence therapeutics

scientific article published on 14 September 2018

Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 fromArabidopsis thaliana

article

High-resolution structures of cholesterol oxidase in the reduced state provide insights into redox stabilization

scientific article

Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana

scientific article

Mechanism of the dehydrogenase reaction of DmpFG and analysis of inter-subunit channeling efficiency and thermodynamic parameters in the overall reaction

scientific article published on 3 June 2013

Molecular features of the copper binding sites in the octarepeat domain of the prion protein

scientific article

Oxidation of cysteine 34 of plasma albumin as a biomarker of oxidative stress

scientific article published on 06 January 2020

Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair

scientific article published on 7 June 2001

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

scientific article published in 2022

Preliminary studies into the inhibition of the cholesterol alpha-glucosyltransferase from Helicobacter pylori using azasugars

scientific article published on 04 March 2010

Production and characterization of recombinant perdeuterated cholesterol oxidase

scientific article

Structural and functional studies of a NADP(+)-specific aldehyde dehydrogenase from the luminescent marine bacterium Vibrio harveyi

scientific article published on 01 January 1997

Structure and function of lipid A-modifying enzymes

scientific article published on 25 September 2019

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity

scientific article

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

scientific article

Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

scientific article published on 21 August 2018

Sub-Angstrom resolution enzyme X-ray structures: is seeing believing?

scientific article published on December 2003

Sub-atomic resolution crystal structure of cholesterol oxidase: what atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity

scientific article (publication date: 7 March 2003)

The Binding and Release of Oxygen and Hydrogen Peroxide Are Directed by a Hydrophobic Tunnel in Cholesterol Oxidase †

scientific article

The Design and Structure of Outer Membrane Receptors from Peroxisomes, Mitochondria, and Chloroplasts

scientific article

The first transcriptomes from field-collected individual whiteflies (Bemisia tabaci, Hemiptera: Aleyrodidae)

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

scientific article

The yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein

scientific article

Thermosensitive mutants of the MPTP and hPTP1B protein tyrosine phosphatases: isolation and structural analysis.

scientific article

Ubiquitin fusion constructs allow the expression and purification of multi-KOW domain complexes of the Saccharomyces cerevisiae transcription elongation factor Spt4/5.

scientific article published on 21 May 2014

List of works by Alice Vrielink

A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase

A missense mutation sheds light on a novel structure-function relationship of RANKL

A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

Atomic resolution density maps reveal secondary structure dependent differences in electronic distribution

Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study.

Biological channeling of a reactive intermediate in the bifunctional enzyme DmpFG.

Cholesterol oxidase: ultrahigh-resolution crystal structure and multipolar atom model-based analysis

Cholesterol oxidases: a study of nature's approach to protein design

Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol oxidase

Computational site-directed mutagenesis studies of the role of the hydrophobic triad on substrate binding in cholesterol oxidase.

Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme-substrate recognition

Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes

Crystal structure of LAAO from Calloselasma rhodostoma with an L-phenylalanine substrate: insights into structure and mechanism

Crystallization and preliminary X-ray analysis of cholesterol oxidase from Brevibacterium sterolicum containing covalently bound FAD

Crystallization and preliminary X-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase--aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600.

Crystallization and preliminary X-ray analysis of the formiminotransferase domain from the bifunctional enzyme formiminotransferase-cyclodeaminase

Crystallization and preliminary diffraction analysis of an engineered cephalosporin acylase.

Detergents in Membrane Protein Purification and Crystallisation.

Direct demonstration of lipid phosphorylation in the lipid bilayer of the biomimetic bicontinuous cubic phase using the confined enzyme lipid A phosphoethanolamine transferase.

Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase

ESR and electron nuclear double resonance characterization of the cholesterol oxidase from Brevibacterium sterolicum in its semiquinone state.

Editorial overview: Catalysis and regulation: Structural features guiding enzyme catalysed processes

Electron spin echo envelope modulation studies of the semiquinone anion radical of cholesterol oxidase from Brevibacterium sterolicum

Enzyme targets for drug design of new anti-virulence therapeutics

Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 fromArabidopsis thaliana

High-resolution structures of cholesterol oxidase in the reduced state provide insights into redox stabilization

Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana

Mechanism of the dehydrogenase reaction of DmpFG and analysis of inter-subunit channeling efficiency and thermodynamic parameters in the overall reaction

Molecular features of the copper binding sites in the octarepeat domain of the prion protein

Oxidation of cysteine 34 of plasma albumin as a biomarker of oxidative stress

Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

Preliminary studies into the inhibition of the cholesterol alpha-glucosyltransferase from Helicobacter pylori using azasugars

Production and characterization of recombinant perdeuterated cholesterol oxidase

Structural and functional studies of a NADP(+)-specific aldehyde dehydrogenase from the luminescent marine bacterium Vibrio harveyi

Structure and function of lipid A-modifying enzymes

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

Sub-Angstrom resolution enzyme X-ray structures: is seeing believing?

Sub-atomic resolution crystal structure of cholesterol oxidase: what atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity

The Binding and Release of Oxygen and Hydrogen Peroxide Are Directed by a Hydrophobic Tunnel in Cholesterol Oxidase †

The Design and Structure of Outer Membrane Receptors from Peroxisomes, Mitochondria, and Chloroplasts

The first transcriptomes from field-collected individual whiteflies (Bemisia tabaci, Hemiptera: Aleyrodidae)

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

The yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein

Thermosensitive mutants of the MPTP and hPTP1B protein tyrosine phosphatases: isolation and structural analysis.

Ubiquitin fusion constructs allow the expression and purification of multi-KOW domain complexes of the Saccharomyces cerevisiae transcription elongation factor Spt4/5.