List of works - Shigeki Takeda

5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion ⬇️

scientific article published on November 6, 2011

A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test.

scientific article published on 17 August 2017

A possible novel mechanism of action of genistein and daidzein for activating thyroid hormone receptor (TR)-mediated transcription.

scientific article published on 23 April 2018

Cloning, expression and characterization of horse L-ferritin in Escherichia coli.

scientific article

Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion

scientific article

Crystallization and preliminary X-ray analysis of gene product 44 from bacteriophage Mu.

scientific article published on 24 December 2004

Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone.

scientific article

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

scientific article published on 31 August 2020

Discovery of the tail tube gene of bacteriophage Mu and sequence analysis of the sheath and tube genes ⬇️

scientific article published on July 30, 1998

Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells.

scientific article

Expression and characterization of a baseplate protein for bacteriophage Mu, gp44.

scientific article published in May 2005

Expression of goat alpha-lactalbumin in Escherichia coli and its refolding to biologically active protein

scientific article published on 01 April 1990

Functional conversion of the homologous proteins alpha-lactalbumin and lysozyme by exon exchange

scientific article published on July 1992

GPR31 and GPR151 are activated under acidic conditions

scientific article published on 23 May 2019

Genomic and proteomic characterization of the largeMyoviridaebacteriophage ϕTMA of the extreme thermophileThermus thermophilus ⬇️

scientific article published on May 1, 2011

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

scientific article

Identification of G protein-coupled receptor genes from the human genome sequence

scientific article (publication date: 5 June 2002)

Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids

scientific article

Identification of physiologically active substances as novel ligands for MRGPRD

scientific article

Identification of surrogate ligands for orphan G protein-coupled receptors ⬇️

scientific article published on December 5, 2003

In vivo and in vitro evaluation of novel μ-opioid receptor agonist compounds.

scientific article published on 14 October 2015

MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer

scientific article

Mapping of functional sites on the primary structure of the contractile tail sheath protein of bacteriophage T4 by mutation analysis.

scientific article

Mapping of functional sites on the primary structure of the tail lysozyme of bacteriophage T4 by mutational analysis.

scientific article published in May 1998

Melanoma antigen family A4 protein produced by transgenic silkworms induces antitumor immune responses

scientific article published on 4 January 2018

Most of it started with T4 phage and was then taken over

scientific article

Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84.

scientific article published on 25 November 2014

Observation of the membrane binding activity and domain structure of gpV, which comprises the tail spike of bacteriophage P2.

scientific article

Observation of unexpected molecular binding activity for Mu phage tail fibre chaperones

scientific article published on 01 December 2019

Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres

scientific article published on 17 June 2019

Production and characterization of the recombinant human mu-opioid receptor from transgenic silkworms.

scientific article published on 4 November 2008

Redesign of the substrate-binding site of hen egg white lysozyme based on the molecular evolution of C-type lysozymes

scientific article published in Journal of Biological Chemistry

Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors

scientific article

Site-Specific Reactivities of Cysteine Residues in Horse L-Apoferritin

scientific article published on 01 February 1995

Staphylococcal Phage in Combination with Staphylococcus Epidermidis as a Potential Treatment for Staphylococcus Aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants

scientific article published on 22 December 2020

Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Galpha16 fusion proteins.

scientific article published on May 2004

Stoichiometry and inter-subunit interaction of the wedge initiation complex, gp10-gp11, of bacteriophage T4

scientific article published on 01 June 2000

Structural studies of the contractile tail sheath protein of bacteriophage T4. 1. Conformational change of the tail sheath upon contraction as probed by differential chemical modification

scientific article published on 01 May 1990

Structural studies of the contractile tail sheath protein of bacteriophage T4. 2. Structural analyses of the tail sheath protein, Gp18, by limited proteolysis, immunoblotting, and immunoelectron microscopy.

scientific article

Structure of the Central Hub of Bacteriophage Mu Baseplate Determined by X-ray Crystallography of gp44

scientific article published on 01 September 2005

The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein.

scientific article

The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity.

scientific article

The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure

scientific article

Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae

scientific article published on 16 May 2018

[Recruitment of enzymatic function to alpha-lactalbumin by protein engineering]

scientific article published on 01 February 1992

List of works by Shigeki Takeda

5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion ⬇️

A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test.

A possible novel mechanism of action of genistein and daidzein for activating thyroid hormone receptor (TR)-mediated transcription.

Cloning, expression and characterization of horse L-ferritin in Escherichia coli.

Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion

Crystallization and preliminary X-ray analysis of gene product 44 from bacteriophage Mu.

Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone.

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Discovery of the tail tube gene of bacteriophage Mu and sequence analysis of the sheath and tube genes ⬇️

Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells.

Expression and characterization of a baseplate protein for bacteriophage Mu, gp44.

Expression of goat alpha-lactalbumin in Escherichia coli and its refolding to biologically active protein

Functional conversion of the homologous proteins alpha-lactalbumin and lysozyme by exon exchange

GPR31 and GPR151 are activated under acidic conditions

Genomic and proteomic characterization of the largeMyoviridaebacteriophage ϕTMA of the extreme thermophileThermus thermophilus ⬇️

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

Identification of G protein-coupled receptor genes from the human genome sequence

Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids

Identification of physiologically active substances as novel ligands for MRGPRD

Identification of surrogate ligands for orphan G protein-coupled receptors ⬇️

In vivo and in vitro evaluation of novel μ-opioid receptor agonist compounds.

MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer

Mapping of functional sites on the primary structure of the contractile tail sheath protein of bacteriophage T4 by mutation analysis.

Mapping of functional sites on the primary structure of the tail lysozyme of bacteriophage T4 by mutational analysis.

Melanoma antigen family A4 protein produced by transgenic silkworms induces antitumor immune responses

Most of it started with T4 phage and was then taken over

Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84.

Observation of the membrane binding activity and domain structure of gpV, which comprises the tail spike of bacteriophage P2.

Observation of unexpected molecular binding activity for Mu phage tail fibre chaperones

Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres

Production and characterization of the recombinant human mu-opioid receptor from transgenic silkworms.

Redesign of the substrate-binding site of hen egg white lysozyme based on the molecular evolution of C-type lysozymes

Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors

Site-Specific Reactivities of Cysteine Residues in Horse L-Apoferritin

Staphylococcal Phage in Combination with Staphylococcus Epidermidis as a Potential Treatment for Staphylococcus Aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants

Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Galpha16 fusion proteins.

Stoichiometry and inter-subunit interaction of the wedge initiation complex, gp10-gp11, of bacteriophage T4

Structural studies of the contractile tail sheath protein of bacteriophage T4. 1. Conformational change of the tail sheath upon contraction as probed by differential chemical modification

Structural studies of the contractile tail sheath protein of bacteriophage T4. 2. Structural analyses of the tail sheath protein, Gp18, by limited proteolysis, immunoblotting, and immunoelectron microscopy.

Structure of the Central Hub of Bacteriophage Mu Baseplate Determined by X-ray Crystallography of gp44

The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein.

The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity.

The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure

Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae

[Recruitment of enzymatic function to alpha-lactalbumin by protein engineering]