List of works - Olga Gursky

Aggregation and fusion of low-density lipoproteins in vivo and in vitro

scientific article

Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights

scientific article published on January 2015

Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis

scientific journal article

Apolipoprotein structure and dynamics.

scientific article

Conformational changes in cubic insulin crystals in the pH range 7-11 ⬇️

scientific article published on November 1, 1992

Crystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil

scientific article published on 4 October 2012

Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition.

scientific article published on 21 February 2009

Does alpha-helix folding necessarily provide an energy source for the protein-lipid binding?

scientific article published on 01 January 2007

Effects of acyl chain length, unsaturation, and pH on thermal stability of model discoidal HDLs.

scientific article published on May 2008

Effects of cholesterol on thermal stability of discoidal high density lipoproteins

scientific article

Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins

scientific article published on 01 April 2003

Effects of oxidation on the structure and stability of human low-density lipoprotein

scientific article published on 20 April 2007

Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets.

scientific article

Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins

scientific article

Effects of salt on the thermal stability of human plasma high-density lipoprotein

scientific article published on 01 April 2006

Electrostatic effects on the stability of discoidal high-density lipoproteins.

scientific article published in August 2005

Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis.

scientific article published on March 2012

Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant.

scientific article published on 29 July 2017

High- and low-temperature unfolding of human high-density apolipoprotein A-2.

scientific article published on September 1996

Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men.

scientific article published on 20 February 2014

Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH ⬇️

scientific article published on May 15, 2011

Human plasma high-density lipoproteins are stabilized by kinetic factors.

scientific article published in April 2003

In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis

scientific article published on 20 June 2017

Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis ⬇️

scientific article published on July 31, 2012

Molecular Insights into Human Hereditary Apolipoprotein A-I Amyloidosis Caused by the Glu34Lys Mutation

scientific article published on 19 September 2018

Monitoring protein aggregation during thermal unfolding in circular dichroism experiments.

scientific article published on February 2006

Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA.

scientific article

Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins.

scientific article

Preface. Role of lipids in protein misfolding

scientific article published on 01 January 2015

Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins

scientific article

Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface.

scientific article published on 20 April 2011

Probing the lipid-free structure and stability of apolipoprotein A-I by mutation

scientific article published on 01 December 2000

Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL.

scientific article published on June 2012

Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes

scientific article published on 07 March 2007

Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis

scientific article published on 25 July 2017

Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response

scientific article published on 20 June 2017

Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner

scientific article published on 01 April 2018

Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve

scientific article published on 24 September 2020

Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

scientific article published on 9 November 2015

Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens.

scientific article published on 25 December 2017

Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I

scientific article

Structural basis for thermal stability of human low-density lipoprotein.

scientific article

Structural stability and functional remodeling of high-density lipoproteins.

scientific article

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

scientific article published on 31 December 2016

Structural studies of N- and C-terminally truncated human apolipoprotein A-I

scientific article published on 01 June 2003

Structure and selectivity of a monovalent cation binding site in cubic insulin crystals.

scientific article

Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks

scientific article published on 31 December 2016

Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.

scientific article published on 26 February 2016

Synergy between serum amyloid A and secretory phospholipase A2.

scientific article

Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation

scientific article published on 01 January 2000

The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain ⬇️

scientific article published on October 20, 2010

The Crystal Structure of the C-Terminal Truncated Apolipoprotein A-I Sheds New Light on Amyloid Formation by the N-Terminal Fragment ⬇️

scientific article published on December 29, 2011

Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation.

scientific article published on 24 May 2016

Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL.

scientific article published on 28 May 2015

Thermodynamic Analysis of Human Plasma Apolipoprotein C-1: High-Temperature Unfolding and Low-Temperature Oligomer Dissociation ⬇️

scientific article published on 01 February 1998

Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma

scientific article

Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases

scientific article published on 18 October 2016

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease

scientific article published on 25 June 2018

List of works by Olga Gursky

Aggregation and fusion of low-density lipoproteins in vivo and in vitro

Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights

Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis

Apolipoprotein structure and dynamics.

Conformational changes in cubic insulin crystals in the pH range 7-11 ⬇️

Crystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil

Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition.

Does alpha-helix folding necessarily provide an energy source for the protein-lipid binding?

Effects of acyl chain length, unsaturation, and pH on thermal stability of model discoidal HDLs.

Effects of cholesterol on thermal stability of discoidal high density lipoproteins

Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins

Effects of oxidation on the structure and stability of human low-density lipoprotein

Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets.

Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins

Effects of salt on the thermal stability of human plasma high-density lipoprotein

Electrostatic effects on the stability of discoidal high-density lipoproteins.

Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis.

Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant.

High- and low-temperature unfolding of human high-density apolipoprotein A-2.

Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men.

Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH ⬇️

Human plasma high-density lipoproteins are stabilized by kinetic factors.

In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis

Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis ⬇️

Molecular Insights into Human Hereditary Apolipoprotein A-I Amyloidosis Caused by the Glu34Lys Mutation

Monitoring protein aggregation during thermal unfolding in circular dichroism experiments.

Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA.

Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins.

Preface. Role of lipids in protein misfolding

Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins

Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface.

Probing the lipid-free structure and stability of apolipoprotein A-I by mutation

Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL.

Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes

Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis

Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response

Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner

Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve

Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens.

Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I

Structural basis for thermal stability of human low-density lipoprotein.

Structural stability and functional remodeling of high-density lipoproteins.

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

Structural studies of N- and C-terminally truncated human apolipoprotein A-I

Structure and selectivity of a monovalent cation binding site in cubic insulin crystals.

Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks

Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.

Synergy between serum amyloid A and secretory phospholipase A2.

Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation

The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain ⬇️

The Crystal Structure of the C-Terminal Truncated Apolipoprotein A-I Sheds New Light on Amyloid Formation by the N-Terminal Fragment ⬇️

Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation.

Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL.

Thermodynamic Analysis of Human Plasma Apolipoprotein C-1: High-Temperature Unfolding and Low-Temperature Oligomer Dissociation ⬇️

Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma

Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease