List of works - Lique M Coolen

A pivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections.

scientific article

A role for neurokinin B in pulsatile GnRH secretion in the ewe.

scientific article published on 04 October 2013

Activation of MAP kinase in lumbar spinothalamic cells is required for ejaculation

scientific article published on 08 March 2010

Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation.

scientific article published on 14 January 2011

Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats.

scientific article published on 21 December 2016

Activation of mu or delta opioid receptors in the lumbosacral spinal cord is essential for ejaculatory reflexes in male rats

scientific article

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration ⬇️

scientific article published on April 16, 2003

Anatomy of the kisspeptin neural network in mammals.

scientific article

Central regulation of ejaculation.

scientific article published in November 2004

Chronic Contusion Spinal Cord Injury Impairs Ejaculatory Reflexes in Male Rats: Partial Recovery by Systemic Infusions of Dopamine D3 Receptor Agonist 7OHDPAT.

scientific article published on 6 October 2015

Chronic Spinal Cord Injury Reduces Gastrin-Releasing Peptide in the Spinal Ejaculation Generator in Male Rats

scientific article published on 10 July 2019

Concurrent exposure to methamphetamine and sexual behavior enhances subsequent drug reward and causes compulsive sexual behavior in male rats.

scientific article published in November 2011

Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT.

scientific article

Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A.

scientific article published on 24 March 2004

Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain.

scientific article

Diurnal and circadian regulation of reward-related neurophysiology and behavior.

scientific article

Diurnal rhythms in neural activation in the mesolimbic reward system: critical role of the medial prefrontal cortex.

scientific article published on 25 April 2013

Diurnal variations in natural and drug reward, mesolimbic tyrosine hydroxylase, and clock gene expression in the male rat.

scientific article published in December 2009

Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes?

scientific article

Do similar neural systems subserve aggressive and sexual behaviour in male rats? Insights from c-Fos and pharmacological studies.

scientific article published on 2 November 2005

Does Dynorphin Play a Role in the Onset of Puberty in Female Sheep?

scientific article

Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats

scientific article published on 06 October 2018

Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe.

scientific article published on 16 January 2017

Effects of Sexual Experience on Psychostimulant- and Opiate-Induced Behavior and Neural Plasticity in the Mesocorticolimbic Pathway

scientific article published on 31 August 2018

Endogenous opioid-induced neuroplasticity of dopaminergic neurons in the ventral tegmental area influences natural and opiate reward.

scientific article

Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe

scientific article published on 01 September 2018

Evidence for Changes in Numbers of Synaptic Inputs onto KNDy and GnRH Neurones during the Preovulatory LH Surge in the Ewe

scientific article published on July 2015

Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes

scientific article

Evidence that gamma-aminobutyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes.

scientific article published on 6 March 2008

Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison.

scientific article published in October 1996

Influences of social reward experience on behavioral responses to drugs of abuse: Review of shared and divergent neural plasticity mechanisms for sexual reward and drugs of abuse.

scientific article

Involvement of nitric oxide in sexual learning via action in the medial preoptic area: theoretical comment on Lagoda et al. (2004).

scientific article published in December 2004

Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.

scientific article

Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes

scientific article published on 19 August 2013

Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats.

scientific article

Lesions of the medial prefrontal cortex cause maladaptive sexual behavior in male rats.

scientific article

Maladaptive Sexual Behavior Following Concurrent Methamphetamine and Sexual Experience in Male Rats is Associated with Altered Neural Activity in Frontal Cortex

scientific article published on 4 January 2017

Male sexual function

scientific article published on 01 November 2004

Medial prefrontal cortex inactivation attenuates the diurnal rhythm in amphetamine reward.

scientific article

Methamphetamine acts on subpopulations of neurons regulating sexual behavior in male rats

scientific article

Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis

scientific article

Morphological plasticity in the neural circuitry responsible for seasonal breeding in the ewe.

scientific article

NMDA and PACAP receptor signaling interact to mediate retinal-induced scn cellular rhythmicity in the absence of light

scientific article

Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with FosB as a Key Mediator

scientific article

Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens

scientific article

Neural activation following sexual behavior in the male and female rat brain.

scientific article

Neural control of ejaculation.

scientific article

Neural mechanisms of female sexual behavior in the rat; comparison with male ejaculatory control.

scientific article

Neural mechanisms of sexual behavior in the male rat: emphasis on ejaculation-related circuits

scientific article published on 22 December 2013

Neural regulation of ejaculation

scientific article

Neural system-enriched gene expression: relationship to biological pathways and neurological diseases.

scientific article published on 08 July 2004

Neural systems mediating seasonal breeding in the ewe.

scientific article

Neurokinin 3 receptor immunoreactivity in the septal region, preoptic area and hypothalamus of the female sheep: colocalisation in neurokinin B cells of the arcuate nucleus but not in gonadotrophin-releasing hormone neurones.

scientific article

Neuronal plasticity and seasonal reproduction in sheep

scientific article

Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats.

scientific article

Opiate exposure and withdrawal induces a molecular memory switch in the basolateral amygdala between ERK1/2 and CaMKIIα-dependent signaling substrates.

scientific article published in September 2013

Orexin and natural reward: feeding, maternal, and male sexual behavior.

scientific article published on January 2012

Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance.

scientific article

Orphanin FQ: evidence for a role in the control of the reproductive neuroendocrine system.

scientific article

Parvocellular subparafascicular thalamic nucleus in the rat: anatomical and functional compartmentalization.

scientific article published in August 2003

Patterns of c-fos expression induced by fluvoxamine are different after acute vs. chronic oral administration.

scientific article published in August 1998

Prenatal Testosterone Exposure Alters GABAergic Synaptic Inputs to GnRH and KNDy Neurons in a Sheep Model of Polycystic Ovarian Syndrome

scientific article published on 01 November 2019

Prenatal Testosterone Treatment Leads to Changes in the Morphology of KNDy Neurons, Their Inputs, and Projections to GnRH Cells in Female Sheep

scientific article

Prenatal programming by testosterone of hypothalamic metabolic control neurones in the ewe.

scientific article published on May 2011

Prenatal testosterone excess decreases neurokinin 3 receptor immunoreactivity within the arcuate nucleus KNDy cell population

scientific article published on February 2015

Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti-related peptide neurons of the adult ewe.

scientific article published on 20 August 2016

Recognizing Team Science Contributions in Academic Hiring, Promotion, and Tenure

scientific article published on 01 August 2020

Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions.

scientific article published on January 2006

Sex differences and effects of prenatal exposure to excess testosterone on ventral tegmental area dopamine neurons in adult sheep

scientific article

Sexual behavior and sex-associated environmental cues activate the mesolimbic system in male rats.

scientific article published in April 2004

Special Issue with Review Articles from the 18th Annual Meeting of the Society for Behavioral Neuroendocrinology in Sydney, Australia in August 2014.

scientific article published in November 2015

Spinal cord control of ejaculation

scientific article

Surge-Like Luteinising Hormone Secretion Induced by Retrochiasmatic Area NK3R Activation is Mediated Primarily by Arcuate Kisspeptin Neurones in the Ewe.

scientific article published on 05 April 2016

Testosterone stimulation of the medial preoptic area and medial amygdala in the control of male hamster sexual behavior: redundancy without amplification.

scientific article published in January 1999

The Roles of Neurokinins and Endogenous Opioid Peptides in Control of Pulsatile LH Secretion

scientific article published on 13 February 2018

The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep

scientific article

The premammillary hypothalamic area of the ewe: anatomical characterization of a melatonin target area mediating seasonal reproduction.

scientific article published on 18 February 2004

The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment.

scientific article published on 25 January 2002

The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior

scientific article

Three-dimensional imaging of KNDy neurons in the mammalian brain using optical tissue clearing and multiple-label immunocytochemistry

scientific article published on 2 February 2018

Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats

scientific article published on June 2007

Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence.

scientific article published in September 2016

mGluR5 activation in the nucleus accumbens is not essential for sexual behavior or cross-sensitization of amphetamine responses by sexual experience.

scientific article published on 2 March 2016

ΔFosB in the nucleus accumbens is critical for reinforcing effects of sexual reward

scientific article

κ-Opioid Receptor Is Colocalized in GnRH and KNDy Cells in the Female Ovine and Rat Brain

scientific article published on 11 April 2016

List of works by Lique M Coolen

A pivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections.

A role for neurokinin B in pulsatile GnRH secretion in the ewe.

Activation of MAP kinase in lumbar spinothalamic cells is required for ejaculation

Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation.

Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats.

Activation of mu or delta opioid receptors in the lumbosacral spinal cord is essential for ejaculatory reflexes in male rats

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration ⬇️

Anatomy of the kisspeptin neural network in mammals.

Central regulation of ejaculation.

Chronic Contusion Spinal Cord Injury Impairs Ejaculatory Reflexes in Male Rats: Partial Recovery by Systemic Infusions of Dopamine D3 Receptor Agonist 7OHDPAT.

Chronic Spinal Cord Injury Reduces Gastrin-Releasing Peptide in the Spinal Ejaculation Generator in Male Rats

Concurrent exposure to methamphetamine and sexual behavior enhances subsequent drug reward and causes compulsive sexual behavior in male rats.

Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT.

Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A.

Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain.

Diurnal and circadian regulation of reward-related neurophysiology and behavior.

Diurnal rhythms in neural activation in the mesolimbic reward system: critical role of the medial prefrontal cortex.

Diurnal variations in natural and drug reward, mesolimbic tyrosine hydroxylase, and clock gene expression in the male rat.

Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes?

Do similar neural systems subserve aggressive and sexual behaviour in male rats? Insights from c-Fos and pharmacological studies.

Does Dynorphin Play a Role in the Onset of Puberty in Female Sheep?

Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats

Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe.

Effects of Sexual Experience on Psychostimulant- and Opiate-Induced Behavior and Neural Plasticity in the Mesocorticolimbic Pathway

Endogenous opioid-induced neuroplasticity of dopaminergic neurons in the ventral tegmental area influences natural and opiate reward.

Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe

Evidence for Changes in Numbers of Synaptic Inputs onto KNDy and GnRH Neurones during the Preovulatory LH Surge in the Ewe

Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes

Evidence that gamma-aminobutyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes.

Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison.

Influences of social reward experience on behavioral responses to drugs of abuse: Review of shared and divergent neural plasticity mechanisms for sexual reward and drugs of abuse.

Involvement of nitric oxide in sexual learning via action in the medial preoptic area: theoretical comment on Lagoda et al. (2004).

Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.

Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes

Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats.

Lesions of the medial prefrontal cortex cause maladaptive sexual behavior in male rats.

Maladaptive Sexual Behavior Following Concurrent Methamphetamine and Sexual Experience in Male Rats is Associated with Altered Neural Activity in Frontal Cortex

Male sexual function

Medial prefrontal cortex inactivation attenuates the diurnal rhythm in amphetamine reward.

Methamphetamine acts on subpopulations of neurons regulating sexual behavior in male rats

Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis

Morphological plasticity in the neural circuitry responsible for seasonal breeding in the ewe.

NMDA and PACAP receptor signaling interact to mediate retinal-induced scn cellular rhythmicity in the absence of light

Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with FosB as a Key Mediator

Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens

Neural activation following sexual behavior in the male and female rat brain.

Neural control of ejaculation.

Neural mechanisms of female sexual behavior in the rat; comparison with male ejaculatory control.

Neural mechanisms of sexual behavior in the male rat: emphasis on ejaculation-related circuits

Neural regulation of ejaculation

Neural system-enriched gene expression: relationship to biological pathways and neurological diseases.

Neural systems mediating seasonal breeding in the ewe.

Neurokinin 3 receptor immunoreactivity in the septal region, preoptic area and hypothalamus of the female sheep: colocalisation in neurokinin B cells of the arcuate nucleus but not in gonadotrophin-releasing hormone neurones.

Neuronal plasticity and seasonal reproduction in sheep

Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats.

Opiate exposure and withdrawal induces a molecular memory switch in the basolateral amygdala between ERK1/2 and CaMKIIα-dependent signaling substrates.

Orexin and natural reward: feeding, maternal, and male sexual behavior.

Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance.

Orphanin FQ: evidence for a role in the control of the reproductive neuroendocrine system.

Parvocellular subparafascicular thalamic nucleus in the rat: anatomical and functional compartmentalization.

Patterns of c-fos expression induced by fluvoxamine are different after acute vs. chronic oral administration.

Prenatal Testosterone Exposure Alters GABAergic Synaptic Inputs to GnRH and KNDy Neurons in a Sheep Model of Polycystic Ovarian Syndrome

Prenatal Testosterone Treatment Leads to Changes in the Morphology of KNDy Neurons, Their Inputs, and Projections to GnRH Cells in Female Sheep

Prenatal programming by testosterone of hypothalamic metabolic control neurones in the ewe.

Prenatal testosterone excess decreases neurokinin 3 receptor immunoreactivity within the arcuate nucleus KNDy cell population

Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti-related peptide neurons of the adult ewe.

Recognizing Team Science Contributions in Academic Hiring, Promotion, and Tenure

Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions.

Sex differences and effects of prenatal exposure to excess testosterone on ventral tegmental area dopamine neurons in adult sheep

Sexual behavior and sex-associated environmental cues activate the mesolimbic system in male rats.

Special Issue with Review Articles from the 18th Annual Meeting of the Society for Behavioral Neuroendocrinology in Sydney, Australia in August 2014.

Spinal cord control of ejaculation

Surge-Like Luteinising Hormone Secretion Induced by Retrochiasmatic Area NK3R Activation is Mediated Primarily by Arcuate Kisspeptin Neurones in the Ewe.

Testosterone stimulation of the medial preoptic area and medial amygdala in the control of male hamster sexual behavior: redundancy without amplification.

The Roles of Neurokinins and Endogenous Opioid Peptides in Control of Pulsatile LH Secretion

The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep

The premammillary hypothalamic area of the ewe: anatomical characterization of a melatonin target area mediating seasonal reproduction.

The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment.

The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior