List of works - Toshikazu Ushijima

A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A

scientific article

A tissue microRNA signature that predicts the prognosis of breast cancer in young women

scientific article published on 15 November 2017

Accumulation of genetic and epigenetic alterations in normal cells and cancer risk

scientific article published on 06 March 2019

Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis.

scientific article published on 13 June 2009

Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis

scientific article published on 06 January 2013

Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model

scientific article published on 13 December 2018

Association between frequent CpG island methylation and HER2 amplification in human breast cancers.

scientific article published on 23 January 2009

Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study.

scientific article published on 8 September 2015

Autophagy impairment by Helicobacter pylori-induced methylation silencing of MAP1LC3Av1 promotes gastric carcinogenesis.

scientific article published on 18 February 2017

BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy

scientific article published on 20 April 2020

Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

scientific article published on 13 May 2019

Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer

scientific article published on 3 October 2013

Cancer epigenetics: now harvesting fruit and seeding for common diseases

scientific article published on 01 December 2014

Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c

scientific article

Compendium of aberrant DNA methylation and histone modifications in cancer

scientific article published on 4 September 2014

Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer

scientific article published on 21 October 2015

Correction to: Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways

scientific article published on 01 January 2020

DNA methylation marker to estimate the breast cancer cell fraction in DNA samples

scientific article published on 14 September 2018

DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis.

scientific article published on 10 May 2014

Degree of methylation burden is determined by the exposure period to carcinogenic factors.

scientific article published on 19 December 2016

Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression

scientific article

Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis.

scientific article published on 18 September 2009

Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma.

scientific article published on 26 June 2018

Diagnostic and therapeutic applications of epigenetics.

scientific article

Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori

scientific article published on 11 December 2019

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

scientific article

Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.

scientific article

Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.

scientific article published on 12 June 2011

Epigenetic mechanisms of chronic pain

scientific article

Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways

scientific article published on 25 September 2019

Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

scientific article published on 30 December 2019

Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.

scientific article published on 13 February 2015

Establishment of a detection system for demethylating agents using an endogenous promoter CpG island.

scientific article

Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1

scientific article published on 22 July 2008

Expression quantitative trait loci analysis of 13 genes in the rat prostate.

scientific article

FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy

scientific article published on 16 September 2019

Fidelity of the methylation pattern and its variation in the genome.

scientific article

Focus on gastric cancer.

scientific article published on February 2004

Frequent involvement of chromatin remodeler alterations in gastric field cancerization.

scientific article

Genetic and epigenetic profiling indicate the proximal tubule origin of renal cancers in end-stage renal disease

scientific article published on 29 August 2020

Genetic polymorphisms and susceptibility to cancer development ⬇️

scientific article published on January 1, 1995

Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma.

scientific article published on 5 January 2017

Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors.

scientific article published on 8 November 2013

Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas

scientific article published on 11 January 2017

Genome-wide profiling of promoter methylation in human

scientific article published on 01 May 2006

Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays.

scientific article published in May 2003

High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.

scientific article

Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization

scientific article published on 19 April 2012

Identification and validation of DNA methylation markers to predict lymph node metastasis of esophageal squamous cell carcinomas.

scientific article published on 2 November 2010

Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers

scientific article

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.

scientific article

Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis.

scientific article

Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan.

scientific article published on 29 September 2015

Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.

scientific article published in October 2009

Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis.

scientific article published in January 2010

Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells.

scientific article

Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells

scientific article published on 2 February 2010

Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation

scientific article published on 27 October 2010

Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.

scientific article published on 12 January 2016

Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

scientific article published on 3 August 2013

LINC00162 confers sensitivity to 5-Aza-2'-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1

scientific article published on 26 March 2019

Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae

scientific article published on 26 September 2007

Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis

scientific article

Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.

scientific article

Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level

scientific article published on 21 September 2020

Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway

scientific article

Metabolomic profiling reveals salivary hypotaurine as a potential early detection marker for medication-related osteonecrosis of the jaw

scientific article published on 12 August 2019

Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons

scientific article published on 15 June 2018

Methylation destiny: Moira takes account of histones and RNA polymerase II

scientific article published on 27 February 2010

Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas.

scientific article published on 12 May 2011

Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers.

scientific article

Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers.

scientific article

Methylation‐Sensitive Representational Difference Analysis and Its Application to Cancer Research ⬇️

scientific article published on March 1, 2003

Novel prodrugs of decitabine with greater metabolic stability and less toxicity

scientific article published on 01 August 2019

Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma.

scientific article published in March 2009

PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma.

scientific article published on 14 August 2017

Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation

scientific article published on 06 February 2017

Predictive value of genetic analysis for pathological complete response to preoperative treatment in HER2 positive, HR negative early breast cancer (PASSION trial).

scientific article

Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation

scientific article published on 11 July 2019

Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent.

scientific article published in April 2013

Promoter methylation profiling of 30 genes in human malignant melanoma.

scientific article

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers

scientific article published on 20 December 2019

Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas.

scientific article

Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy

scientific article published on 8 March 2016

Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers.

scientific article

Roadmap for investigating epigenome deregulation and environmental origins of cancer

scientific article published on 13 September 2017

Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.

scientific article published on 5 June 2012

Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.

scientific article

Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas.

scientific article published on July 2007

Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17

scientific article published on 13 April 2005

Systemic Administration of Small Interfering RNA Targeting Human Nestin Inhibits Pancreatic Cancer Cell Proliferation and Metastasis.

scientific article published on 2 September 2015

Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway

scientific article published on 30 May 2017

The Moment that KRAS Mutation Started to Evolve into Precision Medicine in Metastatic Colorectal Cancer.

scientific article published in November 2016

The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.

scientific article

Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells

scientific article published on 12 June 2013

WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps

scientific article published on 13 June 2017

ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy.

scientific article

List of works by Toshikazu Ushijima

A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A

A tissue microRNA signature that predicts the prognosis of breast cancer in young women

Accumulation of genetic and epigenetic alterations in normal cells and cancer risk

Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis.

Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis

Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model

Association between frequent CpG island methylation and HER2 amplification in human breast cancers.

Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study.

Autophagy impairment by Helicobacter pylori-induced methylation silencing of MAP1LC3Av1 promotes gastric carcinogenesis.

BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy

Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer

Cancer epigenetics: now harvesting fruit and seeding for common diseases

Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c

Compendium of aberrant DNA methylation and histone modifications in cancer

Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer

Correction to: Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways

DNA methylation marker to estimate the breast cancer cell fraction in DNA samples

DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis.

Degree of methylation burden is determined by the exposure period to carcinogenic factors.

Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression

Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis.

Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma.

Diagnostic and therapeutic applications of epigenetics.

Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.

Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.

Epigenetic mechanisms of chronic pain

Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways

Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.

Establishment of a detection system for demethylating agents using an endogenous promoter CpG island.

Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1

Expression quantitative trait loci analysis of 13 genes in the rat prostate.

FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy

Fidelity of the methylation pattern and its variation in the genome.

Focus on gastric cancer.

Frequent involvement of chromatin remodeler alterations in gastric field cancerization.

Genetic and epigenetic profiling indicate the proximal tubule origin of renal cancers in end-stage renal disease

Genetic polymorphisms and susceptibility to cancer development ⬇️

Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma.

Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors.

Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas

Genome-wide profiling of promoter methylation in human

Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays.

High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.

Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization

Identification and validation of DNA methylation markers to predict lymph node metastasis of esophageal squamous cell carcinomas.

Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer.

Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis.

Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan.

Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.

Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis.

Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells.

Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells

Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation

Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.

Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

LINC00162 confers sensitivity to 5-Aza-2'-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1

Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae

Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis

Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.

Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level

Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway

Metabolomic profiling reveals salivary hypotaurine as a potential early detection marker for medication-related osteonecrosis of the jaw

Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons

Methylation destiny: Moira takes account of histones and RNA polymerase II

Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas.

Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers.

Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers.

Methylation‐Sensitive Representational Difference Analysis and Its Application to Cancer Research ⬇️

Novel prodrugs of decitabine with greater metabolic stability and less toxicity

Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma.

PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma.

Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation

Predictive value of genetic analysis for pathological complete response to preoperative treatment in HER2 positive, HR negative early breast cancer (PASSION trial).

Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation