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List of works by Valeria Santini

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

scientific article
Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia

scientific article
Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With Imatinib

scientific article (publication date: 21 March 2011)
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

scientific article
Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes

scientific article published on 10 January 2011
Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia

scientific article published on March 1993
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.

scientific article
Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application.

scientific article published on May 2007
Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes.

scientific article published on 28 July 2009
Homoharringtonine: history, current research, and future direction

scientific article
Effects of azacitidine compared with conventional care regimens in elderly (≥ 75 years) patients with higher-risk myelodysplastic syndromes

scientific article
Clinical management of myelodysplastic syndromes: update of SIE, SIES, GITMO practice guidelines.

scientific article published on 11 February 2010
Influence of JAK2V617F allele burden on phenotype in essential thrombocythemia

scientific article published on 01 January 2008
A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial

scientific article published on April 12, 2013
Randomized Phase III Study of Lenalidomide Versus Placebo in RBC Transfusion-Dependent Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes and Ineligible for or Refractory to Erythropoiesis-Stimulating Agents

scientific article
Azacitidine for the treatment of lower risk myelodysplastic syndromes : a retrospective study of 74 patients enrolled in an Italian named patient program

scientific article published in March 2010
Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine.

scientific article
Proliferation signaling and activation of Shc, p21Ras, and Myc via tyrosine 764 of human granulocyte colony-stimulating factor receptor

scientific article published on March 15, 1998
Deferasirox for transfusion-dependent patients with myelodysplastic syndromes: safety, efficacy, and beyond (GIMEMA MDS0306 Trial).

scientific article
Safety and tolerability of eltrombopag versus placebo for treatment of thrombocytopenia in patients with advanced myelodysplastic syndromes or acute myeloid leukaemia: a multicentre, randomised, placebo-controlled, double-blind, phase 1/2 trial

scientific article
Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib

scientific article
Myelodysplastic syndromes: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published on 25 July 2014
The addition of liposomal doxorubicin to bortezomib, thalidomide and dexamethasone significantly improves clinical outcome of advanced multiple myeloma.

scientific article published on 10 April 2008
Outcome of therapy-related myeloid neoplasms treated with azacitidine

scientific article
Why methylation is not a marker predictive of response to hypomethylating agents.

scientific article published on April 2014
Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine

scientific article published on 15 July 2011
Amifostine: chemotherapeutic and radiotherapeutic protective effects

scientific article
Clinical use of erythropoietic stimulating agents in myelodysplastic syndromes.

scientific article published on January 2011
High rate of remissions in chronic myelomonocytic leukemia treated with 5-azacytidine: results of an Italian retrospective study.

scientific article published on 30 August 2012
Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients.

scientific article published in April 2004
Eltrombopag versus placebo for low-risk myelodysplastic syndromes with thrombocytopenia (EQoL-MDS): phase 1 results of a single-blind, randomised, controlled, phase 2 superiority trial

scientific article
Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells

scientific article published on January 15, 2013
Hypomethylating agents in relapsed and refractory AML: outcomes and their predictors in a large international patient cohort

scientific article published on 01 April 2018
Management recommendations for chronic myelomonocytic leukemia: consensus statements from the SIE, SIES, GITMO groups

scientific article published on September 2013
Novel therapeutic strategies: hypomethylating agents and beyond.

scientific article published on January 2012
Effects of fludarabine and gemcitabine on human acute myeloid leukemia cell line HL 60: direct comparison of cytotoxicity and cellular Ara-C uptake enhancement.

scientific article
Update on developments in the diagnosis and prognostic evaluation of patients with myelodysplastic syndromes (MDS): Consensus statements and report from an expert workshop

scientific article published on 03 December 2011
Anemia as the Main Manifestation of Myelodysplastic Syndromes

scientific article published on June 30, 2015
Quality of life and physicians' perception in myelodysplastic syndromes

scientific article published on May 25, 2012
The potential of amifostine: from cytoprotectant to therapeutic agent

scientific article
Iron overload and chelation therapy in myelodysplastic syndromes.

scientific article published on 24 January 2014
Epigenetics in focus: pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents.

scientific article published on 07 July 2013
Butyrates and decitabine cooperate to induce histone acetylation and granulocytic maturation of t(8;21) acute myeloid leukemia blasts.

scientific article published on December 2005
Sequential cis-platinum and fludarabine with or without arabinosyl cytosine in patients failing prior fludarabine therapy for chronic lymphocytic leukemia: a phase II study

scientific article published on 01 December 1999
Butyrates, as a single drug, induce histone acetylation and granulocytic maturation: possible selectivity on core binding factor-acute myeloid leukemia blasts.

scientific article published on December 2003
Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes

scientific article published on 28 January 2014
The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal.

scientific article published on 13 February 2003
Distinct signal transduction abnormalities and erythropoietin response in bone marrow hematopoietic cell subpopulations of myelodysplastic syndrome patients.

scientific article
Proteomic analysis identifies differentially expressed proteins in AML1/ETO acute myeloid leukemia cells treated with DNMT inhibitors azacitidine and decitabine.

scientific article published on 9 January 2012
Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib

scientific article published on 25 June 2011

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