List of works by Radim Osička

A guide to polarized airway epithelial models for studies of host-pathogen interactions

scientific article published on 02 July 2018

A novel "clip-and-link" activity of repeat in toxin (RTX) proteins from gram-negative pathogens. Covalent protein cross-linking by an Asp-Lys isopeptide bond upon calcium-dependent processing at an Asp-Pro bond

scientific article published on 24 March 2004

ABD-Derived Protein Blockers of Human IL-17 Receptor A as Non-IgG Alternatives for Modulation of IL-17-Dependent Pro-Inflammatory Axis

scientific article published on 09 October 2018

Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins

scientific article published on 27 May 2020

Adenylate cyclase toxin translocates across target cell membrane without forming a pore

scientific article published on 23 February 2010

Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines

scientific article published on 04 August 2014

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

scientific article published on 14 July 2014

Binding of <i>Kingella kingae</i> RtxA Toxin Depends on Cell Surface Oligosaccharides, but Not on β<sub>2</sub> Integrins

scientific article published on 29 November 2020

Biophysical characterization of recombinant human ameloblastin

scientific article published on 01 December 2011

Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.

scientific article published on 16 June 2018

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

scientific article

Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme

scientific article published on 20 September 2015

Bordetella pertussis adenylate cyclase toxin disrupts functional integrity of bronchial epithelial layers.

scientific article published on 4 December 2017

Bordetella pertussis filamentous hemagglutinin itself does not trigger anti-inflammatory interleukin-10 production by human dendritic cells

scientific article published on 30 November 2015

Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores

scientific article

Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis

scientific article published on 10 April 2017

Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding

scientific article published on 07 November 2018

Delivery of multiple epitopes by recombinant detoxified adenylate cyclase of Bordetella pertussis induces protective antiviral immunity

scientific article

Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size

scientific article

Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

scientific article published on 20 June 2019

Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1.

scientific article published on 21 June 2016

Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?

scientific article

Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells

scientific article

Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin

scientific article published on January 2008

Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding

scientific article published on 29 December 2014

Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain

scientific article published on 28 July 2003

Intrinsically disordered enamel matrix protein ameloblastin forms ribbon-like supramolecular structures via an N-terminal segment encoded by exon 5

scientific article published on 19 June 2013

Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif

scientific article published on 14 February 2017

Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells

scientific article published on October 2006

Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin

scientific article published on September 2016

Neisseria meningitidis RTX proteins are not required for virulence in infant rats

scientific article

Novel binders derived from an albumin-binding domain scaffold targeting human prostate secretory protein 94 (PSP94)

scientific article published on 12 August 2015

Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G.

scientific article

Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin.

scientific article published on 5 May 2009

Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes

scientific article published on April 2006

Production of Highly Active Recombinant Dermonecrotic Toxin of Bordetella Pertussis

scientific article published on 15 September 2020

Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin.

scientific article published on 9 January 2014

RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides

scholarly article

RTX proteins: a highly diverse family secreted by a common mechanism

scientific article

Rapid Purification of Endotoxin-Free RTX Toxins

scientific article published on 12 June 2019

Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin

scientific article published on 08 April 2019

Retargeting from the CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzyme-translocating segment of Bordetella adenylate cyclase toxin

scientific article published on 11 May 2020

Segments Crucial for Membrane Translocation and Pore-forming Activity ofBordetellaAdenylate Cyclase Toxin

scientific article published in Journal of Biological Chemistry

Single-step affinity purification of recombinant proteins using a self-excising module from Neisseria meningitidis FrpC.

scientific article published on 28 July 2008

Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes

scientific article

The Bordetella pertussis type III secretion system tip complex protein Bsp22 is not a protective antigen and fails to elicit serum antibody responses during infection of humans and mice

scientific article published on 20 May 2013

The Neisseria meningitidis outer membrane lipoprotein FrpD binds the RTX protein FrpC.

scientific article published on 2 November 2004

The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin

scientific article published on 24 August 2017

The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C.

scientific article

Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin

scientific article published on 21 January 2016

Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia

scientific article published on 12 January 2012

cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.

scientific article

p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells

scientific article

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