List of works by David M Ojcius

130th anniversary of Institut Pasteur: celebrating science

scientific article published on 25 April 2019

130th anniversary of Institut Pasteur: celebrating science

scientific article published on 25 June 2019

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection

scientific article

A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis

scientific article published on 29 November 2017

A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice

scientific article published on 01 November 2004

A new frontier: oral microbes without borders

scientific article published on 20 May 2015

A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway

scientific article published on 31 July 2018

A path forward for the chlamydial virulence factor CPAF

scientific article

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

scientific journal article

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis.

scientific article published on 13 November 2007

ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis

scientific article published on 6 October 2009

Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation.

scientific article published on February 2006

Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol

scientific article published on 16 July 2012

Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection

scientific article (publication date: 2012)

Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin

scientific article

Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope.

scientific article

Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis

scientific article

Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines

scientific article

Alternative functions for the multifarious inflammasome.

scientific article published on June 2016

An iron detection system determines bacterial swarming initiation and biofilm formation.

scientific article

Another year of microbial pathogens and the host immune response

scientific article

Anti-obesogenic and antidiabetic effects of plants and mushrooms.

scientific article

Antiaging effects of bioactive molecules isolated from plants and fungi

scientific article published on 15 January 2019

Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death.

scientific article published on 18 June 2018

Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells

scientific article published on 26 March 2019

Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.

scientific article published on 30 March 2018

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice

scientific article published on 20 June 2017

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

scientific article

Association between periodontal pathogens and systemic disease

scientific article published on 01 February 2019

Bid-Induced Release of AIF/EndoG from Mitochondria Causes Apoptosis of Macrophages during Infection with Leptospira interrogans.

scientific article

Can chlamydia be stopped?

scientific article published on May 2005

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection

scientific article

Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition

scientific article published on 19 July 2020

Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China.

scientific article

Characterizing the intracellular distribution of metabolites in intact Chlamydia-infected cells by Raman and two-photon microscopy.

scientific article

Chikungunya fever--re-emergence of an old disease.

scientific article published on 06 September 2009

Chlamydia and apoptosis: life and death decisions of an intracellular pathogen.

scientific article published in October 2004

Chlamydia trachomatis infection increases the expression of inflammatory tumorigenic cytokines and chemokines as well as components of the Toll-like receptor and NF-κB pathways in human prostate epithelial cells.

scientific article published on 12 March 2014

Chlamydia.

scientific article

Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome

scientific article

ChpK and MazF of the toxin-antitoxin modules are involved in the virulence of Leptospira interrogans during infection

scientific article

Comparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules

scientific article published on 12 July 2004

Comparison of invasion of fibroblasts and macrophages by high- and low-virulence Leptospira strains: colonization of the host-cell nucleus and induction of necrosis by the virulent strain

scientific article published on 11 July 2007

Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.

scientific article published on 11 July 2017

Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells.

scientific article

Cytolethal distending toxin-induced release of interleukin-1β by human macrophages is dependent upon activation of glycogen synthase kinase 3β, spleen tyrosine kinase (Syk) and the noncanonical inflammasome

scientific article published on 18 February 2020

Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae

scientific article

Detection and characterization of mineralo-organic nanoparticles in human kidneys.

scientific article

Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein

scientific article (publication date: 2012)

Development of humoral immunity

scientific article published on 01 August 2019

Dicer regulates activation of the NLRP3 inflammasome

scientific article published on 23 April 2019

Differential involvement of the canonical and noncanonical inflammasomes in the immune response against infection by the periodontal bacteria <i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i>

scientific article published on 23 February 2021

Effects of obesity on depression: A role for inflammation and the gut microbiota.

scientific article

Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients

scientific article published on 26 October 2018

Emerging use of senolytics and senomorphics against aging and chronic diseases

scientific article published on 24 June 2020

Endocytic recycling and vesicular transport systems mediate transcytosis of across cell monolayer

scientific article published on 23 April 2019

Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1.

scientific article

Eosinophils from Murine Lamina Propria Induce Differentiation of Naïve T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid.

scientific article published on 20 November 2015

Evidences on sodium ions compartmentalization in biological systems due to pathological states. A noninvasive NMR study.

scientific article published on September 2003

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells.

scientific article published on 21 March 2009

Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1.

scientific article published on 20 December 2015

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

scientific article published on 23 June 2015

Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

scientific article published on 14 July 2018

HIV theory challenged

scientific article published on 01 August 2007

HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry

scientific article published on 01 September 2019

HIV: breast still best.

scientific article

Hepatitis C Virus Frameshift/Alternate Reading Frame Protein Suppresses Interferon Responses Mediated by Pattern Recognition Receptor Retinoic-Acid-Inducible Gene-I

scientific article

Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo

scientific article

Hormetic Effects of Phytochemicals on Health and Longevity

scientific article published on 03 May 2019

Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages.

scientific article

Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma

scientific article

Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death.

scientific article

Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species.

scientific article published on 25 November 2013

Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR

scientific article published on 25 March 2020

Immunomodulatory Properties of Plants and Mushrooms.

scientific article published on 29 August 2017

Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity

scientific article published on 28 July 2016

Impact of COVID-19 on dental education in the United States

scientific article published on 27 April 2020

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

scientific article

Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai.

scientific article

Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis.

scientific article published on 11 July 2011

Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

scientific article published on 31 July 2009

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation.

scientific article published on September 2003

Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes.

scientific article

Introduction to miniseries on DNA and cancer

scientific article published on 01 March 2015

Investigation of foreign materials in gingival lesions: a clinicopathologic, energy-dispersive microanalysis of the lesions and in vitro confirmation of pro-inflammatory effects of the foreign materials

scientific article published on 20 April 2019

Is the hoopla over CPAF justified?

scientific article published on 15 September 2014

Is the inflammasome relevant for epithelial cell function?

scientific article

Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.

scientific article

Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body

scientific article

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.

scientific article

Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation

scientific article published on 9 February 2018

Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways.

scientific article

Lessons learned from the 2019-nCoV epidemic on prevention of future infectious diseases

scientific article published on 20 February 2020

MERS – A cautionary tale

scientific article published on 21 June 2015

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids.

scientific article published on 29 August 2013

Methyl-accepting chemotaxis proteins 3 and 4 are responsible for Campylobacter jejuni chemotaxis and jejuna colonization in mice in response to sodium deoxycholate

scientific article published on 8 January 2014

MicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in Mice

scientific article published on 31 October 2016

Microbes and Infection turns 20

scientific article published on 30 May 2018

Microbes and Infection: past, present and future.

scientific article published on 24 November 2009

Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1.

scientific article

Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma

scientific article published on 13 November 2019

Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis

scientific article

Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages

scientific journal article

Mushrooms - From cuisine to clinic

scientific article published on 01 November 2014

Myths and Realities Surrounding the Mysterious Caterpillar Fungus.

scientific article published in November 2017

NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4.

scientific article published on 30 October 2017

NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection

scientific article published on 30 July 2018

NK cells kill mycobacteria directly by releasing perforin and granulysin.

scientific article published on 19 August 2014

NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection

scientific article

NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy

scientific article

Nanoparticle conversion to biofilms: in vitro demonstration using serum-derived mineralo-organic nanoparticles

scientific article published on 2 October 2015

Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China.

scientific article published on 30 December 2013

Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome.

scientific article

Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption

scientific article published on 01 June 2018

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

scientific article (publication date: 23 March 2012)

P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation

scientific article published on 02 November 2018

Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells.

scientific article published on 3 February 2017

Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase.

scientific article

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion.

scientific article

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence.

scientific article published on 9 January 2013

Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development.

scientific article

Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice

scientific article published on 28 February 2019

Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections

scientific article published on 13 April 2016

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages.

scientific article

Purinergic signaling during Porphyromonas gingivalis infection

scientific article

Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis

scientific article (publication date: 31 October 2016)

Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines.

scientific article published on December 2008

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.

scientific article

Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin.

scientific article

Reversible inhibition of Chlamydia trachomatis infection in epithelial cells due to stimulation of P2X(4) receptors.

scientific article

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends

scientific article published on 08 June 2020

Salivary biomarkers for the diagnosis and monitoring of neurological diseases

scientific article published on 01 April 2018

Sleep Deprivation and Neurological Disorders

scientific article published on 23 November 2020

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

scientific article

Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation

scientific article published on 31 October 2018

Stimulation and repression of cancer development by caveolae and nitric oxide

scientific article published on 01 September 2015

Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum.

scientific article published on June 2006

Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells

scientific article

TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans.

scientific article

The P2X(7) receptor and intracellular pathogens: a continuing struggle.

scientific article published on 12 February 2009

The Th1 immune response against HIV-1 Gag p24-derived peptides in mice expressing HLA-A02.01 and HLA-DR1

article

The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages

scientific article (publication date: 2012)

The book reopened on infectious diseases.

scientific article

The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif-dependent infection of cells and animals.

scientific article

The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome.

scientific article

The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion.

scientific article

The oral microbiota: living with a permanent guest.

scientific article published on August 2009

The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection

scientific article

The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.

scientific article published on 21 November 2008

Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface

scientific article

Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection.

scientific article published on December 2003

Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection.

scientific article published on 16 December 2012

Valley fever: danger lurking in a dust cloud

scientific article

cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophages

scientific article published on 22 October 2013

is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells

scientific article published on 11 March 2019

vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation

scientific article published on 15 October 2018

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