List of works - David M Ojcius

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

scientific article (publication date: 23 March 2012)

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

scientific journal article

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

scientific article

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

scientific article published on 23 June 2015

The oral microbiota: living with a permanent guest.

scientific article published on August 2009

Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection.

scientific article published on December 2003

Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis

scientific article

Chlamydia and apoptosis: life and death decisions of an intracellular pathogen.

scientific article published in October 2004

Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum.

scientific article published on June 2006

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation.

scientific article published on September 2003

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis.

scientific article published on 13 November 2007

ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis

scientific article published on 6 October 2009

A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice

scientific article published on 01 November 2004

Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

scientific article published on 31 July 2009

Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1.

scientific article

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.

scientific article published on 19 May 2006

Alarmins, inflammasomes and immunity

scientific article published on November 1, 2012

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection

scientific article

Chlamydia.

scientific article

Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai.

scientific article

Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages.

scientific article

Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome

scientific article

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence.

scientific article published on 9 January 2013

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

scientific article published on May 23, 2012

Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-κB Signaling Pathways

scientific article published on January 1, 2012

Porphyromonas gingivalisinfection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells

scientific article published on April 1, 2010

Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages

scientific journal article

Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection

scientific article (publication date: 2012)

Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma

scientific article

The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif‐dependent infection of cells and animals

scientific article published on February 14, 2012

Identification of Collagenase as a Critical Virulence Factor for Invasiveness and Transmission of Pathogenic Leptospira Species

scientific article published on November 25, 2013

The P2X(7) receptor and intracellular pathogens: a continuing struggle.

scientific article published on 12 February 2009

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.

scientific article

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

scientific article

Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin.

scientific article

Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface

scientific article

Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection.

scientific article published on 16 December 2012

Effects of obesity on depression: A role for inflammation and the gut microbiota.

scientific article

Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1.

scientific article published on 20 December 2015

Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation.

scientific article published on February 2006

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

scientific article

Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.

scientific article

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages.

scientific article

The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion.

scientific article

Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase.

scientific article

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids.

scientific article published on 29 August 2013

NK cells kill mycobacteria directly by releasing perforin and granulysin.

scientific article published on 19 August 2014

Comparison of invasion of fibroblasts and macrophages by high- and low-virulence Leptospira strains: colonization of the host-cell nucleus and induction of necrosis by the virulent strain

scientific article published on 11 July 2007

Methyl-accepting chemotaxis proteins 3 and 4 are responsible for Campylobacter jejuni chemotaxis and jejuna colonization in mice in response to sodium deoxycholate

scientific article published on January 8, 2014

Anti-obesogenic and antidiabetic effects of plants and mushrooms.

scientific article

List of works by David M Ojcius

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

The oral microbiota: living with a permanent guest.

Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection.

Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis

Chlamydia and apoptosis: life and death decisions of an intracellular pathogen.

Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum.

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation.

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis.

ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis

A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice

Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1.

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.

Alarmins, inflammasomes and immunity

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection

Chlamydia.

Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai.

Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages.

Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence.

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-κB Signaling Pathways

Porphyromonas gingivalisinfection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells

Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages

Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection

Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma

The mammalian cell entry (Mce) protein of pathogenic Leptospira species is responsible for RGD motif‐dependent infection of cells and animals

Identification of Collagenase as a Critical Virulence Factor for Invasiveness and Transmission of Pathogenic Leptospira Species

The P2X(7) receptor and intracellular pathogens: a continuing struggle.

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin.

Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface

Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection.

Effects of obesity on depression: A role for inflammation and the gut microbiota.

Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1.

Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages.

The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion.

Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase.

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids.

NK cells kill mycobacteria directly by releasing perforin and granulysin.

Comparison of invasion of fibroblasts and macrophages by high- and low-virulence Leptospira strains: colonization of the host-cell nucleus and induction of necrosis by the virulent strain

Methyl-accepting chemotaxis proteins 3 and 4 are responsible for Campylobacter jejuni chemotaxis and jejuna colonization in mice in response to sodium deoxycholate

Anti-obesogenic and antidiabetic effects of plants and mushrooms.