List of works - Timothy Sharpe

A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles

scientific article published on 06 June 2019

A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

scientific article published on 05 May 2020

A molecular mechanism of chaperone-client recognition.

scientific article

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

scientific article

Carboxyl pKa Values and Acid Denaturation of BBL ⬇️

scientific article published on September 15, 2010

Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51

scientific article

FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile

scientific article

General structural motifs of amyloid protofilaments

scholarly article

Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification

scientific article published on 19 January 2016

Regulation of chaperone function by coupled folding and oligomerization

scientific article published on 21 October 2020

Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry.

scientific article

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

scientific article

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

scientific article

Syrosingopine sensitizes cancer cells to killing by metformin

scientific article

Targeting protein-protein interactions and fragment-based drug discovery.

scientific article

The dynamic dimer structure of the chaperone Trigger Factor

scientific article published on 8 December 2017

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

scientific article

List of works by Timothy Sharpe

A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles

A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

A molecular mechanism of chaperone-client recognition.

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

Carboxyl pKa Values and Acid Denaturation of BBL ⬇️

Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51

FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile

General structural motifs of amyloid protofilaments

Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification

Regulation of chaperone function by coupled folding and oligomerization

Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry.

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Syrosingopine sensitizes cancer cells to killing by metformin

Targeting protein-protein interactions and fragment-based drug discovery.

The dynamic dimer structure of the chaperone Trigger Factor

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure