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List of works by Frédéric R Leroux

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns

scientific article

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation

scientific article published in December 2017

Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries

scientific article published on 01 September 2018

Alpha-fluorinated ethers, thioethers, and amines: anomerically biased species.

scientific article

Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III).

scientific article published on 21 July 2017

Atropisomerism, biphenyls, and fluorine: a comparison of rotational barriers and twist angles.

scientific article published on May 2004

Axial chirality control during Suzuki-Miyaura cross-coupling reactions: the tert-butylsulfinyl group as an efficient chiral auxiliary

scientific article

Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands.

scientific article published on 14 September 2011

CF<sub>3</sub>-substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry

scientific article published on 03 February 2021

Catalytic Palladium Phosphination: Modular Synthesis of C1‐Symmetric Biaryl‐Based Diphosphines ⬇️

scientific article published on August 18, 2011

Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling

scientific article published on 13 April 2012

Deprotonative Functionalization of the Difluoromethyl Group

scientific article published on 22 October 2020

Determination of the absolute configuration of phosphinic analogues of glutamate

scientific article published on 24 November 2014

Efficient Synthesis of Quaternary and P-Stereogenic Phosphonium Triflates†

scientific article published on 01 April 2010

Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents

scientific article

Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles

scientific article published on 01 September 2017

Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges

scientific article published on 11 August 2011

In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation

scientific article published on 03 September 2015

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

scientific article published on 4 February 2018

Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.

scientific article

Multiple hydrogen/lithium interconversions at the same benzene nucleus: two at the most.

scientific article published in April 2001

Palladium-Catalyzed Borylation of Phenyl Bromides and Application in One-Pot Suzuki−Miyaura Biphenyl Synthesis

scientific article published on 01 November 2004

Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C–H Bond Activation

scientific article published on 02 May 2013

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls.

scientific article published on June 2015

Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

scientific article published on 15 November 2013

Stereoselective Synthesis of P-Chirogenic Dibenzophosphole–Boranes via Aryne Intermediates

scientific article published on 03 July 2012

Stereoselective Synthesis of o-Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry

scientific article published on 27 June 2012

Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls

scientific article published on 13 June 2018

Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama-Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers.

scientific article published on 31 May 2017

Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds

scientific article published on 9 October 2017

The "Aryne" route to biaryls featuring uncommon substituent patterns

scientific article published on 01 November 2002

Transition‐Metal‐Free Atropo‐Selective Synthesis of Biaryl Compounds Based on Arynes ⬇️

scientific article published on September 27, 2012

Trifluoromethoxy substituted anilines: metalation as the key step for structural elaboration.

scientific article

Trifluoromethyl ethers and -thioethers as tools for medicinal chemistry and drug discovery.

scientific article published on January 2014

[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties

scientific article published on 23 December 2010

alpha-fluorinated ethers as "exotic" entity in medicinal chemistry.

scientific article published on October 2007

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