List of works - Annik Prat

A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy

scientific article

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice

scientific article published on 01 November 2018

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

scientific article published on 17 June 2015

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

scientific article

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

article

Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

scientific article published on 27 July 2017

Automated design of ligands to polypharmacological profiles.

scientific article

Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

scientific article published on 6 April 2013

Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

scientific article published on 16 July 2020

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

scientific article published on 27 January 2011

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

scientific article

Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis

scientific article published on 11 July 2016

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

scientific article

Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

scientific article published on 27 July 2009

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

scientific article

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease.

scientific article published on 19 September 2016

Expression and retinoid modulation of N-arginine dibasic convertase and an aminopeptidase-B in human neuroblastoma cell lines

scientific article published on 01 January 1997

Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

scientific article

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes

scientific article

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

article

Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels

scientific article

Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family ⬇️

scientific article published on November 1, 1997

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

scientific article published on 17 May 2012

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

scientific journal article

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.

scientific article

In utero measurement of heart rate in mouse by noninvasive M-mode echocardiography

scientific article

In vivo evidence that furin from hepatocytes inactivates PCSK9

scientific journal article

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

scholarly article

Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy

scientific article published on 17 June 2011

LDLR Activity and Subcellular Distribution is Sensitive to Estrogen in Mice Lacking PCSK9

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

scientific article

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

scientific article published on 8 June 2015

Loss of endothelial furin leads to cardiac malformation and early postnatal death

scientific article

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor.

scientific article published on 12 July 2018

Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B

scientific journal article

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

scientific article

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

scientific article

PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression

scientific article published in July 2009

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

scientific article

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

scientific article published on 16 December 2009

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

scientific article published on 26 April 2017

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

scientific article

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation

scientific article published on 8 June 2016

Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradation

scientific article published on December 2016

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

scientific article

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

scientific article

Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver

scientific article published on December 2012

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

scientific article published on 10 March 2011

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

scientific article

The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography

scientific article published on 26 August 2011

The Multifaceted Biology of PCSK9 ⬇️

journal article from 'Endocrine Reviews' published in 2022

The Proprotein Convertase 7 Regulates Triglyceride Levels via Enhanced ApoA5 Degradation

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

scientific article published on January 2017

The activation and physiological functions of the proprotein convertases

scientific article published on 08 February 2008

The biology and therapeutic targeting of the proprotein convertases ⬇️

scientific article published on May 1, 2012

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

scientific article

The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)

scientific article

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model

scientific article published on 08 September 2009

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

scientific article

The proprotein convertases and their implication in sterol and/or lipid metabolism

scientific article

The proprotein convertases are potential targets in the treatment of dyslipidemia

scientific article published on 10 March 2007

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

scientific article

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

scientific article published on August 2017

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

scientific article published on 3 May 2017

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

scientific article

List of works by Annik Prat

A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

Automated design of ligands to polypharmacological profiles.

Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease.

Expression and retinoid modulation of N-arginine dibasic convertase and an aminopeptidase-B in human neuroblastoma cell lines

Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels

Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family ⬇️

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.

In utero measurement of heart rate in mouse by noninvasive M-mode echocardiography

In vivo evidence that furin from hepatocytes inactivates PCSK9

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy

LDLR Activity and Subcellular Distribution is Sensitive to Estrogen in Mice Lacking PCSK9

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

Loss of endothelial furin leads to cardiac malformation and early postnatal death

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor.

Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation

Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradation

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography

The Multifaceted Biology of PCSK9 ⬇️

The Proprotein Convertase 7 Regulates Triglyceride Levels via Enhanced ApoA5 Degradation

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

The activation and physiological functions of the proprotein convertases

The biology and therapeutic targeting of the proprotein convertases ⬇️

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

The proprotein convertases and their implication in sterol and/or lipid metabolism

The proprotein convertases are potential targets in the treatment of dyslipidemia

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5