List of works - Helene Blons

A multicenter blinded study evaluating EGFR and KRAS mutation testing methods in the clinical non-small cell lung cancer setting--IFCT/ERMETIC2 Project Part 1: Comparison of testing methods in 20 French molecular genetic National Cancer Institute pl

scientific article published on 30 October 2013

Analysis of Base-Position Error Rate of Next-Generation Sequencing to Detect Tumor Mutations in Circulating DNA.

scientific article published on 13 September 2016

Base-Position Error Rate Analysis of Next-Generation Sequencing Applied to Circulating Tumor DNA in Non-Small Cell Lung Cancer: A Prospective Study.

scientific article

Beyond KRAS status and response to anti-EGFR therapy in metastatic colorectal cancer

scientific article

Beyond the KRAS test

scientific article published on 01 September 2009

Colorectal neuroendocrine carcinomas and adenocarcinomas share oncogenic pathways. A clinico-pathologic study of 12 cases.

scientific article

Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples.

scientific article

Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy.

scientific article

Cross-Validation Study for Epidermal Growth Factor Receptor and KRAS Mutation Detection in 74 Blinded Non-small Cell Lung Carcinoma Samples: A Total of 5550 Exons Sequenced by 15 Molecular French Laboratories (Evaluation of the EGFR Mutation Status f

article

Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma.

scientific article published on July 2002

DeltaN TP63 reactivation, epithelial phenotype maintenance, and survival in lung squamous cell carcinoma

scientific article published on 11 October 2011

Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing.

scientific article published on 15 November 2012

Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis.

scientific article

Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis

article

Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.

scientific article

Dual blockade of epidermal growth factor receptor-induced pathways: a new avenue to treat metastatic colorectal cancer.

scientific article

Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study).

scientific article

Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer

scientific article published on 3 August 2017

Expression and mutational status of treatment-relevant targets and key oncogenes in 123 malignant salivary gland tumours.

scientific article published on 8 August 2013

Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers

scientific article

French multicentric validation of ALK rearrangement diagnostic in 547 lung adenocarcinomas.

scientific article published on 30 April 2015

Functional assessment of p53 in chronic lymphocytic leukemia

scientific article published on 25 February 2011

GJB2 and GJB6 mutations: genotypic and phenotypic correlations in a large cohort of hearing-impaired patients.

scientific article published in June 2005

Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy.

scientific article published in September 2001

Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.

scientific article published on 6 December 2011

Impact of systematic EGFR and KRAS mutation evaluation on progression-free survival and overall survival in patients with advanced non-small-cell lung cancer treated by erlotinib in a French prospective cohort (ERMETIC project--part 2).

scientific article

Intratumoral Immune Cell Densities Are Associated with Lung Adenocarcinoma Gene Alterations

article

Lung cancer molecular testing, what role for Next Generation Sequencing and circulating tumor DNA

scientific article published on 20 January 2016

Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives

scientific article

Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

scientific article published in April 2004

Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma

scientific article published on 01 August 1999

Microsatellite instability analysis for the screening of synchronous endometrial and ovarian cancer in Lynch syndrome

scientific article published on 01 September 2013

Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome

scientific article published on 01 December 2011

Microsatellite instability analysis in uterine cavity washings to detect endometrial cancer in Lynch syndrome

Molecular classification of pulmonary sarcomatoid carcinomas suggests new therapeutic opportunities.

scientific article published on 13 April 2017

Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

scientific article published on 15 June 2017

Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations

scientific article

Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients.

scientific article published on 12 August 2013

Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial

article

Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study.

scientific article published on 05 October 2012

Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab: A Post Hoc Analysis of the PETACC-8 Trial.

scientific article

Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.

scientific article

Prognostic value of KRAS mutations in stage III colon cancer: post hoc analysis of the PETACC8 phase III trial dataset

scientific article published on 6 October 2014

Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by the French ERMETIC-IFCT network

scientific article

Screening of SLC26A4 (PDS) gene in Pendred's syndrome: a large spectrum of mutations in France and phenotypic heterogeneity.

scientific article published in October 2004

Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma

article

The new histologic classification of lung primary adenocarcinoma subtypes is a reliable prognostic marker and identifies tumors with different mutation status: the experience of a French cohort

scientific article

TheGJB2 mutation R75Q can cause nonsyndromic hearing loss DFNA3 or hereditary palmoplantar keratoderma with deafness

scientific article published on 01 August 2005

Three Rounds of External Quality Assessment in France to Evaluate the Performance of 28 Platforms for Multiparametric Molecular Testing in Metastatic Colorectal and Non-Small Cell Lung Cancer.

scientific article published on 02 January 2016

[Cellular and neoplastic otorhinolaryngologic changes, molecular markers and therapeutic potential]

scientific article

[Molecular profiling of non-small cell lung cancer]

scientific article published on 22 February 2014

[What future for circulating tumor DNA? Current data and prospects in colorectal, non-small cell lung and pancreatic cancers].

scientific article

p16: molecular mechanisms involved in the carcinogenesis of various organs

scientific article published on 29 September 2010

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.

scientific article published in April 2000

List of works by Helene Blons

A multicenter blinded study evaluating EGFR and KRAS mutation testing methods in the clinical non-small cell lung cancer setting--IFCT/ERMETIC2 Project Part 1: Comparison of testing methods in 20 French molecular genetic National Cancer Institute pl

Analysis of Base-Position Error Rate of Next-Generation Sequencing to Detect Tumor Mutations in Circulating DNA.

Base-Position Error Rate Analysis of Next-Generation Sequencing Applied to Circulating Tumor DNA in Non-Small Cell Lung Cancer: A Prospective Study.

Beyond KRAS status and response to anti-EGFR therapy in metastatic colorectal cancer

Beyond the KRAS test

Colorectal neuroendocrine carcinomas and adenocarcinomas share oncogenic pathways. A clinico-pathologic study of 12 cases.

Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples.

Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy.

Cross-Validation Study for Epidermal Growth Factor Receptor and KRAS Mutation Detection in 74 Blinded Non-small Cell Lung Carcinoma Samples: A Total of 5550 Exons Sequenced by 15 Molecular French Laboratories (Evaluation of the EGFR Mutation Status f

Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma.

DeltaN TP63 reactivation, epithelial phenotype maintenance, and survival in lung squamous cell carcinoma

Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing.

Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis.

Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis

Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.

Dual blockade of epidermal growth factor receptor-induced pathways: a new avenue to treat metastatic colorectal cancer.

Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study).

Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer

Expression and mutational status of treatment-relevant targets and key oncogenes in 123 malignant salivary gland tumours.

Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers

French multicentric validation of ALK rearrangement diagnostic in 547 lung adenocarcinomas.

Functional assessment of p53 in chronic lymphocytic leukemia

GJB2 and GJB6 mutations: genotypic and phenotypic correlations in a large cohort of hearing-impaired patients.

Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy.

Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.

Impact of systematic EGFR and KRAS mutation evaluation on progression-free survival and overall survival in patients with advanced non-small-cell lung cancer treated by erlotinib in a French prospective cohort (ERMETIC project--part 2).

Intratumoral Immune Cell Densities Are Associated with Lung Adenocarcinoma Gene Alterations

Lung cancer molecular testing, what role for Next Generation Sequencing and circulating tumor DNA

Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives

Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma

Microsatellite instability analysis for the screening of synchronous endometrial and ovarian cancer in Lynch syndrome

Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome

Microsatellite instability analysis in uterine cavity washings to detect endometrial cancer in Lynch syndrome

Molecular classification of pulmonary sarcomatoid carcinomas suggests new therapeutic opportunities.

Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations

Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients.

Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial

Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study.

Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab: A Post Hoc Analysis of the PETACC-8 Trial.

Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.

Prognostic value of KRAS mutations in stage III colon cancer: post hoc analysis of the PETACC8 phase III trial dataset

Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by the French ERMETIC-IFCT network

Screening of SLC26A4 (PDS) gene in Pendred's syndrome: a large spectrum of mutations in France and phenotypic heterogeneity.

Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma

The new histologic classification of lung primary adenocarcinoma subtypes is a reliable prognostic marker and identifies tumors with different mutation status: the experience of a French cohort

TheGJB2 mutation R75Q can cause nonsyndromic hearing loss DFNA3 or hereditary palmoplantar keratoderma with deafness

Three Rounds of External Quality Assessment in France to Evaluate the Performance of 28 Platforms for Multiparametric Molecular Testing in Metastatic Colorectal and Non-Small Cell Lung Cancer.

[Cellular and neoplastic otorhinolaryngologic changes, molecular markers and therapeutic potential]

[Molecular profiling of non-small cell lung cancer]

[What future for circulating tumor DNA? Current data and prospects in colorectal, non-small cell lung and pancreatic cancers].

p16: molecular mechanisms involved in the carcinogenesis of various organs

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.