List of works by Alberto Redaelli

3-D computational analysis of the stress distribution on the leaflets after edge-to-edge repair of mitral regurgitation

scientific article published on 01 November 2002

3-D simulation of the St. Jude Medical bileaflet valve opening process: fluid-structure interaction study and experimental validation.

scientific article published in September 2004

3-Dimensional personalized planning for transcatheter pulmonary valve implantation in a dysfunctional right ventricular outflow tract

scientific article published on 06 December 2019

4D Flow MRI hemodynamic benchmarking of surgical bioprosthetic valves

scientific article published on 22 January 2020

4D MDCT in the assessment of the tricuspid valve and its spatial relationship with the right coronary artery: A customized tool based on computed tomography for the planning of percutaneous procedures

scientific article published on 11 April 2020

A Comprehensive Fluid Dynamic and Geometric Study for an "In-Vitro" Comparison of Four Surgically Implanted Pericardial Stented Valves

scientific article

A Model of Health: Mathematical modeling tools play an important role in optimizing new treatment options for heart disease

scientific article published in July 2015

A Novel Multiparametric Score for the Detection and Grading of Prosthetic Mitral Valve Obstruction in Cases With Different Disc Motion Abnormalities

scientific article published on 04 May 2019

A bioreactor with compliance monitoring for heart valve grafts.

scientific article published on 22 September 2009

A computational model for the optimization of transport phenomena in a rotating hollow-fiber bioreactor for artificial liver

scientific article published on 01 March 2009

A computational study of the hemodynamics after "edge-to-edge" mitral valve repair

scientific article published on 01 December 2001

A computerized method to measure systolic pressure variation (SPV) in mechanically ventilated patients.

scientific article published in February 2002

A microfluidic platform for controlled biochemical stimulation of twin neuronal networks.

scientific article

A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues

scientific article published on 29 October 2018

A new pulsatile blood pump for adult cardiopulmonary bypass: design criteria and preliminary fluid dynamic evaluation

scientific article published on 01 June 1996

A novel approach to the in vitro hydrodynamic study of the aortic valve: mock loop development and test

scientific article published in July 2010

A novel passive left heart platform for device testing and research

scientific article published on 07 February 2015

A numerical performance assessment of a commercial cardiopulmonary by-pass blood heat exchanger

scientific article published on 15 April 2015

A retrospective analysis of health care costs for bone fractures in women with early-stage breast carcinoma

scientific article published in February 2004

Actomyosin interaction: mechanical and energetic properties in different nucleotide binding states

scientific article

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue

scientific article published on 8 September 2016

Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: candidate amino acids involved in Advanced Glycation End-products

scientific article

An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics?

scientific article published on 23 June 2015

An annular prosthesis for the treatment of functional mitral regurgitation: finite element model analysis of a dog bone-shaped ring prosthesis

scientific article published on 01 April 2005

An assisted automated procedure for vessel geometry reconstruction and hemodynamic simulations from clinical imaging

scientific article published in May 2002

An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC.

scientific article published on 24 February 2018

Anisotropic elastic network modeling of entire microtubules.

scientific article published on October 2010

Aortic Root Biomechanics After Sleeve and David Sparing Techniques: A Finite Element Analysis

scientific article published on 15 October 2016

Aortic Root Dynamics in Sleeve Aortic Sparing Procedure: Echocardiographic and Computational Studies

scientific article published on 26 July 2019

Aortic flow after valve sparing root replacement with or without neosinuses reconstruction

scientific article published on 27 July 2018

Aortic root performance after valve sparing procedure: a comparative finite element analysis.

scientific article published on 10 September 2008

Aortic valve repair via neo-chordae technique: mechanistic insight through numerical modelling

scientific article published on 25 December 2011

Aspirin has limited ability to modulate shear-mediated platelet activation associated with elevated shear stress of ventricular assist devices.

scientific article published on February 2016

Assessment of the influence of the compliant aortic root on aortic valve mechanics by means of a geometrical model

scientific article published on 01 December 1997

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues.

scientific article published on 13 January 2016

Bioengineering of the heart

scientific article published on 04 March 2020

Biomechanical drawbacks of different techniques of mitral neochordal implantation: When an apparently optimal repair can fail.

scientific article

Biomechanical implications of the congenital bicuspid aortic valve: a finite element study of aortic root function from in vivo data.

scientific article

Bladder cancer: epidemiology, diagnosis, and management

scientific article

Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis?

scientific article published on 24 October 2018

Blood damage safety of prosthetic heart valves. Shear-induced platelet activation and local flow dynamics: a fluid-structure interaction approach.

scientific article published on 13 June 2009

Breast cancer management: quality-of-life and cost considerations

scientific article

Bubble tracking through computational fluid dynamics in arterial line filters for cardiopulmonary bypass.

scientific article published in September 2009

CAMM techniques for the prediction of the mechanical properties of tendons and ligaments nanostructures.

scientific article published in July 2005

Cardiovascular patient-specific modeling: Where are we now and what does the future look like?

scientific article published on 09 November 2020

Clinical and epidemiologic burden of chronic myelogenous leukemia

scientific article published on February 2004

Comparison of the Performance of a Sutureless Bioprosthesis With Two Pericardial Stented Valves on Small Annuli: An In Vitro Study.

scientific article published on 17 August 2016

Computational analysis of the ductus venosus fluid dynamics based on Doppler measurements.

scientific article published in January 1996

Computational and functional evaluation of a microfluidic blood flow device

scientific article published in July 2007

Computational evaluation of intraventricular pressure gradients based on a fluid-structure approach.

scientific article published in November 1996

Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation

scientific article published on 6 October 2012

Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells.

scientific article published on 23 April 2011

Cost-effectiveness analysis of exemestane compared with megestrol in advanced breast cancer: a model for Europe and Australia

scientific article published in January 2002

Deformation rate controls elasticity and unfolding pathway of single tropocollagen molecules

scientific article published on 14 March 2008

Design of a microfluidic strategy for trapping and screening single cells

scientific article published in December 2015

Development of a Microfluidic Device Embedding High-Conductivity Flexible Electrodes for Three-Dimensional Cell Culture Stimulations

article

Development of a new disposable pulsatile pump for cardiopulmonary bypass: computational fluid-dynamic design and in vitro tests

scientific article published on 01 May 2002

Differential Effects of Aortic Valve Replacement on Aortic Circumferential Strain in Aortic Stenosis and Aortic Insufficiency

scientific article published on 27 October 2020

Do cardiac stabilizers really stabilize? Experimental quantitative analysis of mechanical stabilization.

scientific article

Does the Ventrica magnetic vascular positioner (MVP) for coronary artery bypass grafting significantly alter local fluid dynamics? A numeric study

scientific article published in July 2007

Does the type of suture technique affect the fluid-dynamic performance of bioprostheses implanted in small aortic roots? Results from an in vitro study.

scientific article published on 24 October 2014

Doppler derived quantitative flow estimate in coronary artery bypass graft: a computational multiscale model for the evaluation of the current clinical procedure

scientific article published on 5 November 2007

Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging

scientific article

Dynamic finite element analysis of the aortic root from MRI-derived parameters.

scientific article published on 8 January 2010

Economic burden of acute myeloid leukemia: a literature review.

scientific article published on May 2004

Effect of the valve design on pressure drop, pressure recovery, and spatial positioning of vena contracta

scientific article published on 02 January 2020

Elastic stabilization alone or combined with rigid fusion in spinal surgery: a biomechanical study and clinical experience based on 82 cases.

scientific article

Electrical conditioning of adipose-derived stem cells in a multi-chamber culture platform

scientific article published on 17 February 2014

Epidemiology and clinical burden of acute myeloid leukemia

scientific article published on October 1, 2003

Estimation of the binding force of the collagen molecule-decorin core protein complex in collagen fibril

scientific article published in March 2005

Evaluation of 4D flow MRI-based non-invasive pressure assessment in aortic coarctations

scientific article published on 09 July 2019

Experimental quantification of the fluid dynamics in blood-processing devices through 4D-flow imaging: A pilot study on a real oxygenator/heat-exchanger module

scientific article published on 15 December 2017

Fabrication of 3D cell-laden hydrogel microstructures through photo-mold patterning

scientific article published on 20 May 2013

Finite element modelling of the tricuspid valve: A preliminary study

scientific article published in December 2010

Flow dynamics of the St Jude Medical Symmetry aortic connector vein graft anastomosis do not contribute to the risk of acute thrombosis.

scientific article published in July 2004

Fluid-dynamic results of in vitro comparison of four pericardial bioprostheses implanted in small porcine aortic roots

scientific article published on 20 November 2014

Fluid-structure interaction and in vitro analysis of a real bileaflet mitral prosthetic valve to gain insight into Doppler-silent thrombosis

scientific article published on 04 May 2019

Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm

scientific article published on 01 November 2001

Functional and Biomechanical Effects of the Edge-to-Edge Repair in the Setting of Mitral Regurgitation: Consolidated Knowledge and Novel Tools to Gain Insight into Its Percutaneous Implementation.

scientific article published on 17 December 2014

Generating Multicompartmental 3D Biological Constructs Interfaced through Sequential Injections in Microfluidic Devices.

scientific article published on 7 March 2017

Haemodynamics and mechanics following partial left ventriculectomy: a computer modeling analysis.

scientific article published in January 2004

Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study

scientific article published on 19 April 2006

Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach

scientific article published on 21 August 2015

Hemolysate-mediated platelet aggregation: an additional risk mechanism contributing to thrombosis of continuous flow ventricular assist devices

scientific article published on 20 November 2015

Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up

scientific article published on 05 January 2011

High Frequency Components of Hemodynamic Shear Stress Profiles are a Major Determinant of Shear-Mediated Platelet Activation in Therapeutic Blood Recirculating Devices

scientific article published on 10 July 2017

High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes

scientific article

How to predict diffusion of medium-sized molecules in polymer matrices. From atomistic to coarse grain simulations.

scientific article published on 12 March 2010

Hydration and distance dependence of intermolecular shearing between collagen molecules in a model microfibril

scientific article published on 03 July 2012

Hydrodynamic and Geometric Behavior of Two Pericardial Prostheses Implanted in Small Aortic Roots.

scientific article published on 4 May 2017

Immediate Impact of Prosthetic Graft Replacement of the Ascending Aorta on Circumferential Strain in the Descending Aorta

scientific article published on 21 August 2019

Impact of different aortic valve calcification patterns on the outcome of transcatheter aortic valve implantation: A finite element study.

scientific article published on 25 March 2016

Impact of modeling fluid-structure interaction in the computational analysis of aortic root biomechanics

scientific article published on 01 September 2013

In vitro and in silico approaches to quantify the effects of the Mitraclip® system on mitral valve function

scientific article published on 10 November 2016

In vitro assessment of mitral valve function in cyclically pressurized porcine hearts.

scientific article

In vitro hemodynamics and valve imaging in passive beating hearts

scientific article published on 3 March 2012

In vitro study of aortic valves treated with neo-chordae grafts: hydrodynamics and tensile force measurements

scientific article published on 04 January 2011

In vivo quantification of helical blood flow in human aorta by time-resolved three-dimensional cine phase contrast magnetic resonance imaging

scientific article

In-vitro study of a porcine quadricuspid aortic valve

scientific article

Influence of Different Antithrombotic Regimens on Platelet-Mediated Thrombin Generation in Patients with Left Ventricular Assist Devices

scientific article published on 01 April 2020

Influence of the aortic valve leaflets on the fluid-dynamics in aorta in presence of a normally functioning bicuspid valve.

scientific article published on 6 May 2015

Interaction forces and interface properties of KIF1A kinesin-alphabeta tubulin complex assessed by molecular dynamics.

scientific article published on 30 September 2008

Intracardiac visualization of transcatheter aortic valve and valve-in-valve implantation in an in vitro passive beating heart.

scientific article published in January 2013

Intraventricular pressure drop and aortic blood acceleration as indices of cardiac inotropy: a comparison with the first derivative of aortic pressure based on computer fluid dynamics

scientific article published on 01 June 1998

Is it possible to assess the best mitral valve repair in the individual patient? Preliminary results of a finite element study from magnetic resonance imaging data

scientific article

Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

Left ventricular modelling: a quantitative functional assessment tool based on cardiac magnetic resonance imaging

scientific article published on 23 March 2011

Mechanical characterization of actomyosin complex by molecular mechanics simulations

scientific article published on 01 January 2010

Mechanical model of the tubulin dimer based on molecular dynamics simulations

scientific article published on 01 August 2008

Mechanical properties of physiological and pathological models of collagen peptides investigated via steered molecular dynamics simulations.

scientific article published on 20 September 2008

Mechanical response and conformational changes of alpha-actinin domains during unfolding: a molecular dynamics study

scientific article published on 18 November 2006

Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow: hydrodynamics of sorption.

scientific article published in June 2010

Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow: molecular interactions.

scientific article published in June 2010

Mechanistic insight into the physiological relevance of helical blood flow in the human aorta: an in vivo study.

scientific article published on 22 July 2010

Mesh updating in fluid-structure interactions in biomechanics: an iterative method based on an uncoupled approach.

scientific article published in January 1997

Microfabricated Physiological Models for In Vitro Drug Screening Applications

scientific article published on 15 December 2016

Microfabricated polyester conical microwells for cell culture applications.

scientific article

Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devices.

scientific article published on 28 August 2017

Microfluidic approaches for the assessment of blood cell trauma: a focus on thrombotic risk in mechanical circulatory support devices

scientific article

Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation.

scientific article published on December 2015

Microfluidic flow-based platforms for induction and analysis of dynamic shear-mediated platelet activation-Initial validation versus the standardized hemodynamic shearing device

scientific article published on 22 May 2018

Mitral leaflet modeling: Importance of in vivo shape and material properties

scientific article published on 25 June 2011

Mitral valve finite element modeling: implications of tissues' nonlinear response and annular motion.

scientific article published in December 2009

Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios

scientific article

Mixed impact of torsion on LV hemodynamics: A CFD study based on the Chimera technique

scientific article published on 18 July 2019

Molecular and mesoscale mechanisms of osteogenesis imperfecta disease in collagen fibrils

scientific article

Molecular and nanostructural mechanisms of deformation, strength and toughness of spider silk fibrils

scientific article published on 01 July 2010

Molecular assessment of the elastic properties of collagen-like homotrimer sequences

scientific article published on 12 April 2005

Molecular dynamics investigation of halogenated amyloidogenic peptides

scientific article published on 24 April 2019

Molecular dynamics simulations provide insights into the substrate specificity of FAOX family members

scientific article published on 21 June 2016

Multi-scale analysis of the toraymyxin adsorption cartridge. Part I: molecular interaction of polymyxin B with endotoxins

scientific article published on 01 February 2006

Multi-scale analysis of the toraymyxin adsorption cartridge. Part II: computational fluid-dynamic study.

scientific article published in February 2006

Myosin cross-bridge mechanics: geometrical determinants for continuous sliding

scientific article published on 01 December 2001

Myosin head mechanical performance under different conformational change mechanisms

scientific article published in July 2004

Nanomechanics of collagen microfibrils

scientific article published on January 2013

Nanostructure and stability of calcitonin amyloids

scientific article

Novel insights by 4D Flow imaging on aortic flow physiology after valve-sparing root replacement with or without neosinuses.

scientific article published in February 2018

Numerical fluid-dynamic optimization of microchannel-provided porous scaffolds for the co-culture of adherent and non-adherent cells.

scientific article published in March 2009

Numerical simulation of the dynamics of a bileaflet prosthetic heart valve using a fluid-structure interaction approach

scientific article published on 24 June 2008

On the Use of the Platelet Activity State Assay for the In Vitro Quantification of Platelet Activation in Blood Recirculating Devices for Extracorporeal Circulation.

scientific article published on 8 January 2016

On the importance of blood rheology for bulk flow in hemodynamic models of the carotid bifurcation

scientific article published on 12 July 2011

Opening-closing pattern of four pericardial prostheses: results from an in vitro study of leaflet kinematics.

scientific article

Optimisation of a stentless valve prosthesis based on an analytic parametric model of the aortic valve.

scientific article published in March 1998

Outflow conditions for image-based hemodynamic models of the carotid bifurcation: implications for indicators of abnormal flow.

scientific article published on September 2010

Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid-Structure Interaction Approach

scientific article published on 17 August 2020

Platelet Adhesion and Thrombus Formation in Microchannels: The Effect of Assay-Dependent Variables

scientific article published on 23 January 2020

Platelet activation due to hemodynamic shear stresses: damage accumulation model and comparison to in vitro measurements

scientific article published on January 2008

Platelet activation is a preoperative risk factor for the development of thromboembolic complications in patients with continuous-flow left ventricular assist device.

scientific article published on 28 December 2017

Poroelastic finite element analysis of a bone specimen under cyclic loading

scientific article published on 01 February 1999

Possible role of decorin glycosaminoglycans in fibril to fibril force transfer in relative mature tendons--a computational study from molecular to microstructural level

scientific article published on 01 October 2003

Prediction of post-stenting biomechanics in coarcted aortas: A pilot finite element study

scientific article published on 21 April 2020

Prediction of stenting related adverse events through patient-specific finite element modelling

scientific article published on 13 August 2018

Preliminary design and optimization of an ECC blood pump by means of a parametric approach

scientific article published on 01 July 1995

Prosthetic aortic graft replacement of the ascending thoracic aorta alters biomechanics of the native descending aorta as assessed by transthoracic echocardiography

scientific article published on 12 March 2020

Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support

scientific article published on 18 February 2019

Q-TWiST analysis of cyclophosphamide, epirubicin, fluorouracil versus cyclophosphamide, methotrexate, fluorouracil treatment for premenopausal women with node-positive breast cancer

scientific article published in January 2005

Quality of Life and Economic Considerations in the Management of Prostate Cancer

scientific article published on January 1, 2003

Quantitative analysis of bulk flow in image-based hemodynamic models of the carotid bifurcation: the influence of outflow conditions as test case

scientific article published on 30 June 2010

Rational backbone redesign of a Fructosyl Peptide Oxidase to widen its active site access tunnel

scientific article published on 14 August 2020

Reliable CFD-based estimation of flow rate in haemodynamics measures

scientific article

Reliable magnetic reversible assembly of complex microfluidic devices: fabrication, characterization, and biological validation

Response of two annular prostheses to functional mitral regurgitation main determinants: an in vitro evaluation

scientific article published on 01 November 2010

Restricted cusp motion in right-left type of bicuspid aortic valves: a new risk marker for aortopathy

scientific article published on 03 November 2011

Review: Engineering of thermostable enzymes for industrial applications

scientific article published on 11 January 2018

Routine clinical anti-platelet agents have limited efficacy in modulating hypershear-mediated platelet activation associated with mechanical circulatory support.

scientific article published on 5 December 2017

Screening, prevention and socioeconomic costs associated with the treatment of colorectal cancer

scientific article published on January 2003

Shape of Aquatic Animals and Their Swimming Efficiency

scientific article published in 2014

Shear-Mediated Platelet Activation Enhances Thrombotic Complications in Patients With LVADs and Is Reversed After Heart Transplantation

scientific article published on 01 May 2019

Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay.

scientific article published on August 2015

Short- and long-term effects of acute myeloid leukemia on patient health-related quality of life

scientific article published on February 2004

Simulation of functional tricuspid regurgitation using an isolated porcine heart model

scientific article published on 01 November 2011

Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains.

scientific article published in January 2009

Skin nanostructural features determine suture biomechanics.

scientific article published in June 2003

Smoothed Particle Hydrodynamics multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets

scientific article published on 31 January 2020

Special Issue "Micro and Nano Flows 2016 (MNF2016) - Biomedical Stream".

scientific article published in October 2017

Structural analysis and ion translocation mechanisms of the muscle-type acetylcholine receptor channel

scientific article published on 24 June 2013

Synthetic dataset generation for the analysis and the evaluation of image-based hemodynamics of the human aorta.

scientific article

Systolic anterior motion after mitral valve repair: a predictive computational model

scientific article published in October 2017

Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platforms

scientific article published on 3 May 2017

The Geoform disease-specific annuloplasty system: a finite element study

scientific article published on 01 July 2007

The MICELI (MICrofluidic, ELectrical, Impedance): Prototyping a Point-of-Care Impedance Platelet Aggregometer

scientific article published on 11 February 2020

The aortic interleaflet triangles annuloplasty: a multidisciplinary appraisal.

scientific article published on 11 February 2011

The assignment of velocity profiles in finite element simulations of pulsatile flow in arteries

scientific article published on 01 May 1997

The burden and outcomes associated with four leukemias: AML, ALL, CLL and CML.

scientific article

The health economics of bladder cancer: a comprehensive review of the published literature.

scientific article published on January 2003

The hemodynamic effects of double-orifice valve repair for mitral regurgitation: a 3D computational model

scientific article published on 01 April 1999

Thermal stabilization of the deglycating enzyme Amadoriase I by rational design

scientific article published on 14 February 2018

Thrombotic Risk of Rotor Speed Modulation Regimes of Contemporary Centrifugal Continuous-flow Left Ventricular Assist Devices

scientific article published on 15 October 2020

Toward patient-specific simulations of cardiac valves: state-of-the-art and future directions

scientific article

Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices: Application of a Novel Fluid-Structure Interaction-Based Strategy to the Penn State 12 cc Device

scientific article published in June 2017

Transcatheter Edge-to-Edge Treatment of Functional Tricuspid Regurgitation in an Ex Vivo Pulsatile Heart Model

scientific article published in September 2016

Trends in biomedical engineering: focus on Patient Specific Modeling and Life Support Systems

scientific article published on May 2011

Two fluid-structure approaches for 3D simulation of St. Jude Medical bileaflet valve opening

scientific article published on 01 January 2007

Validation of a Novel Microscale Mold Patterning Protocol Based on Gelatin Methacrylate Photopolymerizable Hydrogels

Ventricular motion during the ejection phase: a computational analysis.

scientific article published in July 2000

Viscoelastic properties of model segments of collagen molecules

scientific article published on 21 December 2011

Visualization and simulated surgery of the left ventricle in the virtual pathological heart of the Virtual Physiological Human

scientific article published on 30 March 2011

Womersley number-based estimates of blood flow rate in Doppler analysis: in vivo validation by means of phase-contrast MRI.

scientific article

Womersley number-based estimation of flow rate with Doppler ultrasound: sensitivity analysis and first clinical application

scientific article

“HyperShear in a channel”: A microfluidic facsimile of ventricular assist devices to reduce thrombotic risk and enhance patient safety