List of works - Pasquale Zizza

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

scientific article

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy

scientific article published on January 2014

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

scientific article

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

scientific article published on 18 April 2019

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage

scientific article

Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs

scientific article published on 15 January 2016

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

scientific article

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article published on 5 February 2015

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

scientific article published on 11 December 2013

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

scientific article published on 27 November 2013

Glycerophosphoinositol-4-phosphate enhances SDF-1α-stimulated T-cell chemotaxis through PTK-dependent activation of Vav

scientific article published on 28 July 2007

Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport

scientific article

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer

scientific article published on 08 July 2020

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article

Identification of novel interactors of human telomeric G-quadruplex DNA

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein

scientific article published on 01 October 2019

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

scientific article

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

scientific article

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

scientific article published on 24 September 2018

Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activity

scientific article

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

scientific article

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

article

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

scientific article

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

scientific article published on 01 April 2019

Tailoring a lead-like compound targeting multiple G-quadruplex structures

scientific article published on 27 November 2018

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

scientific article

The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth.

scientific article

The glycerophosphoinositols and their cellular functions

scientific article published on 01 February 2012

The glycerophosphoinositols: cellular metabolism and biological functions.

scientific article published on 09 August 2009

The natural phosphoinositide derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses

scientific article published on 9 June 2017

List of works by Pasquale Zizza

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage

Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

Glycerophosphoinositol-4-phosphate enhances SDF-1α-stimulated T-cell chemotaxis through PTK-dependent activation of Vav

Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Identification of novel interactors of human telomeric G-quadruplex DNA

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activity

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

Tailoring a lead-like compound targeting multiple G-quadruplex structures

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth.

The glycerophosphoinositols and their cellular functions

The glycerophosphoinositols: cellular metabolism and biological functions.

The natural phosphoinositide derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses