List of works - Michelle Roche

6-Iodonordihydrocapsaicin

article published in 2009

A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats

scientific article published on March 2014

Alterations in the endocannabinoid system in the rat valproic acid model of autism.

scientific article

Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study

scientific article published on 31 December 2019

Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors

scientific article published on 22 January 2020

Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats

scientific article published on 3 April 2008

Brain CB₂ Receptors: Implications for Neuropsychiatric Disorders

scientific article

Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia.

scientific article published on December 2016

Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain.

scientific article published on 10 December 2015

Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype

scientific article published on 06 October 2014

Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat.

scientific article

Circuitry underlying regulation of the serotonergic system by swim stress.

scientific article

Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain.

scientific article published on 30 January 2015

Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways

scientific article published in April 2016

Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear

scientific article published on 27 September 2009

Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions

scientific article published on 16 October 2010

Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

scientific article published on 01 March 2018

Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats

scientific article

Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System

scientific article published on 23 August 2020

FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.

scientific article published on 20 July 2017

FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus

scientific article published on 16 September 2014

Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.

scientific article published on 17 September 2011

For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders

scientific article published on 17 March 2015

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

scientific article

High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity

scientific article

Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli.

scientific article published on 25 September 2013

In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids

scientific article published on 29 September 2006

Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats

scientific article published on 13 December 2018

Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury

scientific article published on 11 July 2013

Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state

scientific article published in February 2014

Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression

scientific article

Modulation of conditioned fear, fear-conditioned analgesia, and brain regional c-Fos expression following administration of muscimol into the rat basolateral amygdala

scientific article

N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism.

scientific article

Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression ⬇️

scientific article published on December 6, 2011

Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats

scientific article published on 19 July 2013

Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.

scientific article

Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid.

scientific article

Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats

scientific article published on 21 January 2020

Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

scientific article

Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains

scientific article

Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat.

scientific article published on 31 August 2016

Stress-induced hyperalgesia

scientific article published on 08 July 2014

Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate

scientific article

The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress

scientific article

The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats

scientific article published on 23 October 2007

The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats

scientific article published on 24 February 2009

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone.

scientific article

The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action

scientific article published on June 2013

The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner

scientific article published on 14 July 2018

Trans-species assessment of antidepressant activity in a rodent model of depression.

scientific article

Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain

scientific article published on 3 November 2011

List of works by Michelle Roche

6-Iodonordihydrocapsaicin

A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats

Alterations in the endocannabinoid system in the rat valproic acid model of autism.

Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study

Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors

Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats

Brain CB₂ Receptors: Implications for Neuropsychiatric Disorders

Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia.

Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain.

Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype

Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat.

Circuitry underlying regulation of the serotonergic system by swim stress.

Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain.

Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways

Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear

Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions

Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats

Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System

FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.

FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus

Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.

For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity

Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli.

In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids

Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats

Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury

Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state

Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression

Modulation of conditioned fear, fear-conditioned analgesia, and brain regional c-Fos expression following administration of muscimol into the rat basolateral amygdala

N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism.

Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression ⬇️

Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats

Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.

Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid.

Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats

Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains

Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat.

Stress-induced hyperalgesia

Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate

The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress

The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats

The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone.

The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action

The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner

Trans-species assessment of antidepressant activity in a rodent model of depression.

Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain