List of works - Julie Zikherman

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

scientific article

Alternative splicing of CD45: the tip of the iceberg.

scientific article published in December 2008

Antigen receptor signaling in the rheumatic diseases

scientific article published on 30 January 2009

Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.

scientific article published on 27 February 2015

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

scientific article

GC B cells 'AKT' to blunt BCR signaling

scientific article published on 01 June 2019

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

scientific article published on 3 February 2017

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

scientific article published on 9 March 2018

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

scientific article published on 14 April 2009

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases

scientific article published on January 2013

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

scientific article published on 31 August 2020

Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45

scientific article

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

scientific article published on 08 April 2019

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

scientific article published on 05 June 2019

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

scientific article published on April 2009

Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance

scientific article published on 10 February 2014

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

scientific article

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival ⬇️

scientific article published on November 30, 2011

Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance

scientific article published on 20 October 2019

The role of T cell receptor signaling thresholds in guiding T cell fate decisions

scientific article

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

scientific article published on 8 February 2013

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

scientific article published on 14 November 2011

List of works by Julie Zikherman

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

Alternative splicing of CD45: the tip of the iceberg.

Antigen receptor signaling in the rheumatic diseases

Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

GC B cells 'AKT' to blunt BCR signaling

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival ⬇️

Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance

The role of T cell receptor signaling thresholds in guiding T cell fate decisions

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.