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List of works by Jorg Kleeff

A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk.

scientific article published on 5 April 2017

ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer

scientific article

Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells

scientific article

Adaptation of the human pancreas to inhibition of luminal proteolytic activity ⬇️

scientific article published on August 1, 1998

Addressing the challenges of pancreatic cancer: future directions for improving outcomes

scientific article published on 17 October 2014

Adenovirus mediated transfer of a truncated fibroblast growth factor (FGF) typ I receptor blocks FGF2 signaling in pancreatic cancer cells

Altered Expression and Localization of the Tight Junction Protein ZO-1 in Primary and Metastatic Pancreatic Cancer

scientific article published on 01 October 2001

An audit of outcomes of a series of periampullary carcinomas.

scientific article

Asymptomatic pancreatic lesions: new insights and clinical implications.

scientific article published on September 2012

Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.

scientific article

B7‐H3 and Its Role in Antitumor Immunity ⬇️

scientific article published on November 28, 2010

Bcl-xl antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine ⬇️

scientific article published on October 15, 2001

Beger's operation and the Berne modification: origin and current results.

scientific article published on 02 October 2009

Brain Metastasis in Colorectal Cancer Patients: Survival and Analysis of Prognostic Factors

scientific article published on 6 June 2015

CANCER-STELLATE CELL INTERACTIONS INHIBIT ANGIOGENESIS AND PERPETUATE THE HYPOXIA-FIBROSIS CYCLE IN PANCREATIC CANCER

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

scientific article

Cartilage oligomeric matrix protein expression in hepatocellular carcinoma and the cirrhotic liver

scientific article published on 01 March 2004

Cellular Heterogeneity of Pancreatic Stellate Cells, Mesenchymal Stem Cells, and Cancer-Associated Fibroblasts in Pancreatic Cancer

scientific article published on 15 December 2020

Central pancreatic head resection in chronic pancreatitis — a new simple surgical approach to solve head related complications: First results of a phase I prospective evaluation

Chirurgie maligner Pankreastumoren

scientific article published on 01 February 2009

Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.

scientific article published on 30 April 2014

Chronic pancreatitis

scientific article published on 7 September 2017

Colorectal cancer surgery remains effective with rising patient age.

scientific article

Comparative analysis of the revenues of pylorus-preserving pancreatic head resections and laparoscopic cholecystectomies as prototypic surgical procedures in the German health-care system ⬇️

scientific article published on June 19, 2013

Comparison of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography (FLT PET) and FDG PET/CT for the detection and characterization of pancreatic tumours

scientific article published on 26 January 2012

Complexity of molecular alterations impacts pancreatic cancer prognosis.

scientific article published on January 2013

Concomitant over-expression of activin/inhibin β subunits and their receptors in human pancreatic cancer ⬇️

scientific article published on September 11, 1998

Correction to: Outcomes After Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer: A Pan-European Retrospective Cohort Study.

scientific article published on 20 March 2018

Correlation of glypican-1 expression with TGF-β, BMP, and activin receptors in pancreatic ductal adenocarcinoma

scientific article published on 01 November 2006

Could hyponatremia be a marker of anastomotic leakage after colorectal surgery? A single center analysis of 1,106 patients over 5 years

scientific article published on 23 May 2014

Das inoperable Pankreaskarzinom – palliative interventionelle und chirurgische Therapie

scientific article published on 13 December 2010

Decrease of global methylation improves significantly hepatic differentiation of Ad-MSCs: possible future application for urea detoxification

scientific article published on 10 April 2012

Defining new pancreatic tumour entities by molecular analysis.

scientific article published on 18 May 2009

Delayed complications after pancreatic surgery: Pancreatic insufficiency, malabsorption syndrome, pancreoprivic diabetes mellitus and pseudocysts

scientific article published on June 2015

Detection of circulating tumor cells by cytokeratin 20 and prostate stem cell antigen RT-PCR in blood of patients with gastrointestinal cancers

scientific article published on 01 May 2003

Die autoimmune Pankreatitis — eine chirurgische Krankheit?

Differential localization and activation of mast cells in chronic pancreatitis of different etiologies

Differentiation of Autoimmune Pancreatitis from Pancreatic Cancer Remains Challenging

scientific article published on 01 June 2019

Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma.

scientific article published on November 2011

Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis

scientific article published on September 2003

Disturbance of the substance P/neurokinin receptor 1 pathway in inflammatory bowel disease

article published in 2003

Do we need sequential local therapy following neoadjuvant chemotherapy for locally advanced pancreatic cancer?

scientific article published on 04 December 2019

Down-Regulation of DOC-2 in Colorectal Cancer Points to Its Role as a Tumor Suppressor in This Malignancy

scientific article published on 01 September 2002

Ductal obstruction promotes formation of pre-neoplastic lesions from the pancreatic ductal compartment

scientific article published on 12 December 2018

Effect of Antecolic Reconstruction on Delayed Gastric Emptying After the Pylorus-Preserving Whipple Procedure

scientific article published on 01 November 2005

Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines.

scientific article published on 15 July 2014

Effect of preoperative biliary drainage on bacterial flora in bile of patients with periampullary cancer

scientific article

Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial

scientific article published in The Lancet

Endoscopic versus surgical treatment for chronic pancreatitis

Energy metabolism and proliferation in pancreatic carcinogenesis ⬇️

scientific article published on March 20, 2012

Erratum zu: Einsatz biologischer Netze bei der Bauchdeckenrekonstruktion. Ergebnisse einer Umfrage in Deutschland

scholarly article published in Der Chirurg

Expression and significance of FXYD-3 protein in gastric adenocarcinoma.

scientific article published on January 2010

Expression of FXYD-3 is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy.

scientific article published on 14 March 2009

Expression of FXYD3 Protein in Relation to Biological and Clinicopathological Variables in Colorectal Cancers

scientific article published on 02 December 2009

Expression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma.

scientific article

Expression of MAC30 in Rectal Cancers with or without Preoperative Radiotherapy

scientific article published on 01 January 2006

Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers

scientific article published on 01 January 2007

Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells

scientific article published on 25 February 2007

Expression of the Multidrug-Resistance 1 (MDR1) Gene and Prognosis in Human Pancreatic Cancer

article

Fas and Fas-ligand expression in human pancreatic cancer.

scientific article published on March 2000

Few genes are associated with the capability of pancreatic ductal adenocarcinoma cells to grow in the liver of nude rats

scientific article

First case of spontaneous myospherulosis of the liver.

scientific article published on 4 October 2012

From tissue turnover to the cell of origin for pancreatic cancer ⬇️

scientific article published on July 12, 2011

Further characterization of autologous NeoHepatocytes for in vitro toxicity testing

article

Further technical and digital development in minimally invasive and conventional surgery

scientific article published in March 2014

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

scientific article published on 26 July 2018

Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells

scientific article (publication date: 15 July 2001)

Heparanase expression in hepatocellular carcinoma and the cirrhotic liver

scientific article published on 01 July 2003

Heparanase expression in primary and metastatic pancreatic cancer

scientific article (publication date: 15 June 2001)

Hepatobiliary and pancreatic: Autoimmune pancreatitis

scientific article published on 01 April 2007

How fibrosis influences imaging and surgical decisions in pancreatic cancer ⬇️

scientific article published on October 2, 2012

Human Hepatocytes: Isolation, Culture, and Quality Procedures

article

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

scientific article published on 02 September 2008

Identification of Disease-specific Genes in Chronic Pancreatitis Using DNA Array Technology ⬇️

scientific article published on December 1, 2001

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

scientific article published on 06 August 2018

Immunotherapy of pancreatic cancer

scientific article published on 22 March 2019

Influence of High-Dose Pancreatic Enzyme Treatment on Pancreatic Function in Healthy Volunteers

article

Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.

scientific article published on 24 October 2015

Insulin-Like Growth Factor Signaling as a Therapeutic Target in Pancreatic Cancer ⬇️

scientific article published on June 1, 2011

Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

scientific article published on 22 February 2019

Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases.

scientific article

Intra-operative wound irrigation to reduce surgical site infections after abdominal surgery: a systematic review and meta-analysis.

scientific article

Level of hospital care and outcome of gastric cancer: a population-based evaluation of the Munich Cancer Registry

scientific article published on 15 March 2014

Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells.

scientific article

Loss of ONECUT1 expression in human pancreatic cancer cells.

scientific article

Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis

scientific article published on 15 December 2018

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice ⬇️

scientific article published on April 8, 2013

Management of hepatobiliary cystadenocarcinoma

Massive intra-abdominal bleeding caused by nontraumatic rupture of a vein in the colorenal ligament: Report of a case ⬇️

scientific article published on March 2, 2011

Mast cell distribution and activation in chronic pancreatitis ⬇️

scientific article published on November 1, 2001

Metabolism gene signatures and surgical site infections in abdominal surgery

scientific article published on 16 January 2015

Metastasis to the pancreas: characterization by morphology and contrast enhancement features on CT and MRI.

scientific article published on 23 April 2008

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

scientific article published on 3 April 2015

Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40.

scientific article published on 23 February 2006

Molecular versus Conventional Markers in Pancreatic Cancer ⬇️

scientific article published on January 1, 1997

Operation nach Kausch-Whipple

article

Osteopontin but not osteonectin favors the metastatic growth of pancreatic cancer cell lines

scientific article published on 26 July 2010

Outcome of gastric cancer in the elderly: a population-based evaluation of the Munich Cancer Registry.

scientific article published on 11 August 2015

Outcomes After Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer: A Pan-European Retrospective Cohort Study

scientific article published on 12 March 2018

Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience

scientific article published on 22 August 2015

Palliative interventional and surgical therapy for unresectable pancreatic cancer

scientific article published on 14 February 2011

Palliative resections versus palliative bypass procedures in pancreatic cancer—a systematic review ⬇️

scientific article published on August 26, 2011

Pancreatic Cancer and FOLFIRINOX: Should We Resect All Responders?

scientific article published in February 2018

Pancreatic cancer

article

Pancreatic cancer risk in relation to lifetime smoking patterns, tobacco type, and dose-response relationships

scientific article published on 12 February 2020

Pancreatic fistula after pancreatic head resection: A problem of the past?

Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review

scientific article

Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767): Perioperative and Long-term Results of a Multicenter Randomized Controlled Trial

scientific article published on July 2015

Pankreassegmentresektion

scientific article published on 01 January 2009

Peroxisome Proliferator-Activated Receptor gamma negatively regulates liver regeneration after partial hepatectomy via the HGF/c-Met/ERK1/2 pathways

scientific article published in Scientific Reports

Postoperative negative-pressure incision therapy following open colorectal surgery (Poniy): study protocol for a randomized controlled trial

scientific article

Potential role of Th17 cells in the pathogenesis of type 2 autoimmune pancreatitis.

scientific article

Precancerous lesions of the biliary tree

scientific article published on 01 April 2013

Preoperative Serum Bilirubin and Lactate Levels Predict Postoperative Morbidity and Mortality in Liver Surgery: A Single-Center Evaluation.

scientific article published on 17 September 2014

RE: Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic Cancer

scientific article published on 29 October 2014

Recurrent duodenal ulcer bleeding as the first manifestation of a solid pseudopapillary neoplasm of the pancreas with hepatic metastases

scientific article published on 13 May 2013

Reduced risk of pancreatic cancer associated with asthma and nasal allergies.

scientific article

Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer

scientific article published on 18 September 2007

Resektion beim fortgeschrittenen Pankreaskarzinom nach multimodaler Vorbehandlung

scientific article published on 01 May 2016

Response evaluation following neoadjuvant treatment of pancreatic cancer patients

scientific article published on February 2013

Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

scientific article published on 06 April 2019

Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives.

scientific article published on 10 January 2018

S3-guideline exocrine pancreatic cancer

scientific article

Seltene Koinzidenz im Bereich der Kardia

scientific article published on 01 January 2015

Severe Colitis After an Alcohol Enema

scientific article published on 01 February 2018

Strategies to improve the outcome in locally advanced pancreatic cancer

scientific article published on 06 February 2015

Surgical approaches for resection of pancreatic cancer: an overview.

scientific article published on February 2002

Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers

scientific article published on 01 October 2000

Systematic review and meta-analysis of prophylactic gastroenterostomy for unresectable advanced pancreatic cancer.

scientific article published on July 2009

T1 Pancreatic Cancer With Lymph Node Metastasis and Perineural Invasion of the Celiac Trunk

scientific article published on 08 August 2008

Targeted therapy of pancreatic cancer: biomarkers are needed

scientific article published on 02 March 2017

Tenascin C and annexin II expression in the process of pancreatic carcinogenesis.

scientific article

The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma.

scientific article published on 24 October 2017

The Role of Diagnostic Laparoscopy in Pancreatic and Periampullary Malignancies ⬇️

scientific article published on June 1, 1998

The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer ⬇️

scientific article published on November 1, 1998

The helix-loop-helix protein Id2 is overexpressed in human pancreatic cancer ⬇️

scientific article published on September 1, 1998

The human endo-glycosidase heparanase is over-expressed in primary and metastatic pancreatic cancer

The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer

scientific article

The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance

scientific article published on March 2012

The plasminogen activator/plasmin system is up-regulated after acute necrotizing pancreatitis in human beings

scientific article published on 01 July 1998

The role of hypoxia in pancreatic cancer: a potential therapeutic target?

scientific article

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications ⬇️

scientific article published on June 19, 2012

The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis

scientific article published on 14 April 2020

Therapeutic developments in pancreatic cancer: current and future perspectives

scientific article published on 01 June 2018

Transarterial Chemoembolization of Liver Metastases As Symptomatic Therapy of Lipase Hypersecretion Syndrome ⬇️

scientific article published on July 9, 2012

Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.

scientific article published in October 1998

Tumor initiating cells in pancreatic cancer: A critical view.

scientific article published on December 2009

Tumor microenvironment and progression of pancreatic cancer.

scientific article published on September 2010

Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells.

scientific article

Update on surgical treatment of pancreatic neuroendocrine neoplasms

scientific article

Value of diffusion-weighted MR imaging in the diagnosis of lymph node metastases in patients with cholangiocarcinoma

scientific article published on 7 June 2016

What is the most accurate test to differentiate pancreatic cystic neoplasms?

Wound edge protectors in open abdominal surgery to reduce surgical site infections: a systematic review and meta-analysis.

scientific article

Zentrales Patientenmanagement in der Chirurgie

scientific article published on 01 September 2003

[Immune function in the early stage of acute pancreatitis]

scientific article published on 01 June 1997

[Preferential expression of cartilage oligomeric matrix protein in degenerating acinar cells in chronic pancreatitis and in chronic pancreatitis-like lesions]

scientific article published on 01 May 2003

[Transforming growth factor-beta controls pathogenesis of Crohn disease]

scientific article published on 01 January 1998

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