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List of works by Kin Sing Stephen Lee

"Turn-on" protein fluorescence: in situ formation of cyanine dyes

scientific article published on 14 January 2015

A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine.

scientific article published in February 2017

Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.

scientific article published on 31 March 2017

An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension

scientific article

Asymmetric Total Synthesis of 19,20-Epoxydocosapentaenoic Acid, a Bioactive Metabolite of Docosahexaenoic Acid

scientific article published on 21 November 2019

Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time

scientific article published on 21 November 2018

Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids.

scientific article published on 2 December 2016

Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy.

scientific article

Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.

scientific article published on 10 April 2017

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration

scientific article published on 16 November 2020

Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.

scientific article

Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization

scientific article published on 21 August 2017

Dissection of the critical binding determinants of cellular retinoic acid binding protein II by mutagenesis and fluorescence binding assay

scientific article published on August 2009

Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways

scientific article published on 03 September 2019

Elucidating the exact role of engineered CRABPII residues for the formation of a retinal protonated Schiff base

scientific article

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain

scientific article published on 6 July 2015

Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase

scientific article

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

scientific article published on 28 June 2019

Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids

scientific article published on 12 September 2018

Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling.

scientific article published on 6 November 2017

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

scientific article

Epoxy fatty acids mediate analgesia in murine diabetic neuropathy.

scientific article published on 15 September 2016

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

scientific article published on 3 April 2013

Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase

scientific article published on 5 December 2012

Identification of potent inhibitors of the chicken soluble epoxide hydrolase.

scientific article

Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding.

scientific article published on 28 June 2016

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation

scientific article

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

scientific article

Method for sorting and pairwise selection of nanobodies for the development of highly sensitive sandwich immunoassays

journal article published in 2015

Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation ⬇️

scientific article published on May 2016

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis.

scientific article published on 18 May 2016

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy

scientific article

PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells

scientific article published on 6 October 2014

Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase

scientific article published on 23 January 2016

Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase

scientific article published on 28 October 2016

Rational Design of a Colorimetric pH Sensor from a Soluble Retinoic Acid Chaperone

scientific article

Remarkable axial ligand effect on regioselectivity towards terminal alkenes in epoxidation of dienes by a robust manganese porphyrin

scientific article published on 01 March 2003

Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes

scientific article published on 20 December 2016

Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice

scientific article published on 6 October 2016

Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis

scientific article published on 29 March 2017

Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.

scientific article

Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.

scientific article

Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice

scientific article published on 28 August 2015

Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors

scientific article

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.

scientific article published in May 2017

Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis

scientific article published on 25 February 2019

Tuning the Electronic Absorption of Protein-Embedded All-trans-Retinal

scientific article

Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis

scientific article published on 14 March 2013

ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.

scientific article published on 21 June 2017

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