List of works - Jeanette H Leusen

A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA.

scientific article published on 06 October 2015

A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling.

scientific article published on 19 September 2014

A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

scientific article published in July 2005

A novel polymorphism in the coding region of CYBB, the human gp91-phox gene

scientific article published on 01 May 1996

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

scientific article published on 3 December 2015

Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice.

scientific article published on 5 March 2014

Anti–GM1 IgG antibodies induce leukocyte effector functions via Fcγ receptors ⬇️

scientific article published on May 1, 2003

Association of the leukocyte immunoglobulin G (Fcgamma) receptor IIIa-158V/F polymorphism with inflammatory myopathies in Dutch patients

scientific article published on 01 June 2009

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

scientific article published on 01 January 2020

Boosting antibody therapy with complement

scientific article published on 01 June 2012

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice ⬇️

scientific article published on January 23, 2012

Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness.

scientific article

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

scientific article published on 18 November 2018

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice

scientific article published on 01 June 2003

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

scientific article

Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease ⬇️

scientific article published on August 1, 1997

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain".

scientific article published in August 2016

Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells"

scientific article published on 01 April 2018

CpG oligodeoxynucleotides enhance FcgammaRI-mediated cross presentation by dendritic cells.

scientific article published on 10 June 2004

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.

scientific article published on 12 November 2012

Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.

scientific article published on 30 August 2010

Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.

scientific article published in August 2000

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

scientific article

Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity

scientific article

Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.

scientific article published on February 2006

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease

scientific article

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2m(1) antibody.

scientific article published on November 2013

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

scientific article published on 27 April 2017

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

scientific article published on 22 June 2018

Expression of CD64 (FcγRI) in skin of patients with acute GVHD

scientific article published on 17 January 2011

Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents

scientific article published on 15 December 2020

Fc receptor inside-out signaling and possible impact on antibody therapy.

scientific article

Fc receptor-mediated immunity against Bordetella pertussis

scientific article published on 01 December 2001

FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells

scientific article published on 29 October 2014

FcgammaRI (CD64) resides constitutively in lipid rafts.

scientific article published on 7 January 2008

FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

scientific article published on 01 January 2018

Fcγ receptor IIIA genotype is associated with rituximab response in antimyelin-associated glycoprotein neuropathy

scientific article published on 31 January 2014

Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing

scientific article

Flow cytometric determination of FcgammaRIIa (CD32) polymorphism.

scientific article published on 6 October 2004

Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly

scientific article published on 01 January 2000

Functional characteristics of the high affinity IgG receptor, FcγRI.

scientific article published on March 2011

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

scholarly article

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

scientific article published on 28 August 2019

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

scientific article published on 04 March 2019

Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab

scientific article published on 8 October 2013

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

scientific article published on 28 January 2016

Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

scientific article published on 16 June 2016

Identification of a tumor-specific allo-HLA-restricted γδTCR

scientific article published on 01 October 2019

IgA as therapeutic antibody

scientific article

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition

scientific article published on 05 November 2019

IgG antibodies in food allergy influence allergen-antibody complex formation and binding to B cells: a role for complement receptors.

scientific article published on 30 August 2013

Immune effector functions of human IgG2 antibodies against EGFR

scientific article published on 03 October 2018

Immunoreceptors: evolution, structure and therapeutic applications ⬇️

scientific article (publication date: December 2012)

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

scientific article published on 14 October 2015

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

scientific article published on 30 March 2010

Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C

scientific article published on 01 September 1993

Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.

scientific article

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

scientific article

Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.

scientific article published on September 2008

Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family.

scientific article published on July 1996

Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system.

scientific article

Intravenous immune globulin suppresses angiogenesis in mice and humans

scientific article published on 28 January 2016

Isolation from purulent sputum of an antigen reactive with antibodies in serum of patients with Wegener's granulomatosis.

scientific article

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

scientific article published on 25 August 2016

Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA.

scientific article published in October 2002

Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.

scientific article

Mechanisms of action of CD20 antibodies ⬇️

scientific article published on November 20, 2012

Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI

scientific article published on 24 July 2018

Meeting report on immunoreceptors 2014.

scientific article published in March 2015

Modulation of FcgammaRI (CD64) ligand binding by blocking peptides of periplakin.

scientific article

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

scientific article published on 01 June 2018

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies.

scientific article published on 22 February 2018

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies

scientific article published on 01 January 2020

OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.

scientific article

Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells.

scholarly article

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

scientific article published on 11 April 2019

Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail.

scientific article published on 26 November 2007

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

scientific article published on 24 June 2015

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

scientific article published on 11 February 2011

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo.

scientific article published on 19 March 2018

Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer

scientific article

Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections.

scientific article published on 22 October 2010

Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.

scientific article published on March 2006

Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing

scientific article published on 25 September 2015

Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions

scientific article published on 16 August 2017

Specificity and Effector Functions of Human RSV-Specific IgG from Bovine Milk

scientific article

Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions.

scientific article

Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread

scientific article published on 14 January 2015

The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain.

scientific article published on July 1999

The Fcγ receptor IIA R131H gene polymorphism is associated with endothelial function in patients with hypercholesterolaemia.

scientific article published on 20 July 2011

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

scientific article published on 17 June 2016

The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma

scientific article published on 01 February 2006

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden.

scientific article published on 31 August 2011

The latest developments with anti-CD20 monoclonal antibodies in chronic lymphocytic leukemia

scientific article published on 10 August 2018

c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcRgamma-chain.

scientific article published on July 2010

List of works by Jeanette H Leusen

A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA.

A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling.

A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

A novel polymorphism in the coding region of CYBB, the human gp91-phox gene

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice.

Anti–GM1 IgG antibodies induce leukocyte effector functions via Fcγ receptors ⬇️

Association of the leukocyte immunoglobulin G (Fcgamma) receptor IIIa-158V/F polymorphism with inflammatory myopathies in Dutch patients

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

Boosting antibody therapy with complement

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice ⬇️

Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness.

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease ⬇️

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain".

Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells"

CpG oligodeoxynucleotides enhance FcgammaRI-mediated cross presentation by dendritic cells.

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.

Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.

Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity

Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2m(1) antibody.

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

Expression of CD64 (FcγRI) in skin of patients with acute GVHD

Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents

Fc receptor inside-out signaling and possible impact on antibody therapy.

Fc receptor-mediated immunity against Bordetella pertussis

FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells

FcgammaRI (CD64) resides constitutively in lipid rafts.

FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

Fcγ receptor IIIA genotype is associated with rituximab response in antimyelin-associated glycoprotein neuropathy

Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing

Flow cytometric determination of FcgammaRIIa (CD32) polymorphism.

Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly

Functional characteristics of the high affinity IgG receptor, FcγRI.

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

Identification of a tumor-specific allo-HLA-restricted γδTCR

IgA as therapeutic antibody

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition

IgG antibodies in food allergy influence allergen-antibody complex formation and binding to B cells: a role for complement receptors.

Immune effector functions of human IgG2 antibodies against EGFR

Immunoreceptors: evolution, structure and therapeutic applications ⬇️

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C

Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.

Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family.

Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system.

Intravenous immune globulin suppresses angiogenesis in mice and humans

Isolation from purulent sputum of an antigen reactive with antibodies in serum of patients with Wegener's granulomatosis.

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA.

Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.

Mechanisms of action of CD20 antibodies ⬇️

Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI

Meeting report on immunoreceptors 2014.

Modulation of FcgammaRI (CD64) ligand binding by blocking peptides of periplakin.

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies.

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies

OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.

Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells.

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail.

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.