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List of works by Haruhiro Higashida

A KCR1 variant implicated in susceptibility to the long QT syndrome

scientific article published on October 13, 2010

A Study of Single Nucleotide Polymorphisms of the SLC19A1/RFC1 Gene in Subjects with Autism Spectrum Disorder.

scientific article published on 19 May 2016

A custom magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism

scientific article

A longitudinal study of auditory evoked field and language development in young children

scientific article published on 24 July 2014

A monoclonal antibody raised against a synthetic oxytocin peptide stains mouse hypothalamic neurones

scientific article published on 26 November 2019

A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome

scientific article published on September 23, 2012

A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg

scientific article published on 05 March 2012

ADP-ribosyl cyclase coupled with receptors via G proteins.

scientific article published in December 1997

AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists

scientific journal article

Acetylcholine stimulates cyclic ADP-ribose formation via M1 muscarinic receptors in rat superior cervical ganglion.

scientific article published in September 2005

Activation of Ca2+/calmodulin-dependent protein kinase II by stimulation with bradykinin in neuroblastoma x glioma hybrid NG108-15 cells

scientific article published on December 4, 1992

Activation of inward current associated with M-potassium current inhibition in m1-muscarinic receptor-transformed NG108-15 cells by KST-5452, a novel cognition enhancer.

scientific article published on May 1994

Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder

scientific article published on 19 March 2013

Anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder

scientific article

Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats.

scientific article published in September 1996

Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population

scientific article

Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults

scientific article

Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism

scientific article

Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder: a child-customised magnetoencephalography (MEG) study

scientific article

Atypical development of the central auditory system in young children with Autism spectrum disorder.

scientific article

Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts.

scientific article published on July 1991

Ba2+ current oscillations modulated by cyclic AMP and phorbol esters in ras-transformed fibroblasts

scientific article published on February 14, 1992

Biological basis for social recognition: CD38 controls oxytocin secretion

scientific article published in November 2007

Both linopirdine- and WAY123,398-sensitive components of I K(M,ng) are modulated by cyclic ADP ribose in NG108-15 cells.

scientific article published in December 2000

Bradykinin B2 receptor-induced and inositol tetrakisphosphate-evoked Ca2+ entry is sensitive to a protein tyrosine phosphorylation inhibitor in ras-transformed NIH/3T3 fibroblasts.

scientific article published on October 1996

Bradykinin-induced cytosolic Ca2+ oscillations and inositol tetrakisphosphate-induced Ca2+ influx in voltage-clamped ras-transformed NIH/3T3 fibroblasts.

scientific article published on September 1993

Bradykinin-induced phosphoinositide-dependent responses in protein kinase C down-regulated NCB-20 cells.

scientific article

Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders

scientific article

CD38 and autism spectrum disorders

scientific article published in November 2013

CD38 and its role in oxytocin secretion and social behavior.

scientific article published on 23 December 2011

CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.

scientific article published on 23 September 2013

CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.

scientific article published on 05 February 2010

Ca2+ influx evoked by inositol-3,4,5,6-tetrakisphosphate in ras-transformed NIH/3T3 fibroblasts.

scientific article published on March 1994

Ca2+ influx gated by inositol-3,4,5,6-tetrakisphosphate in NIH/3T3 fibroblasts.

scientific article published on May 1994

Ca2+ release and Ca2+ influx in Chinese hamster ovary cells expressing the cloned mouse B2 bradykinin receptor: tyrosine kinase inhibitor-sensitive and- insensitive processes

scientific article published on 01 January 1997

Changes in autistic trait indicators in parents and their children with ASD: A preliminary longitudinal study.

scientific article published on 11 June 2015

Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome.

scientific article

Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA

scientific article published on October 1, 1992

Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome.

scientific article published in April 2003

Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome

scientific article published on 01 February 2005

Coupling of m2 and m4 muscarinic acetylcholine receptor subtypes to Ca(2+)-dependent K+ channels in transformed NL308 neuroblastoma x fibroblast hybrid cells

scientific article published on 01 March 1993

Coupling of muscarinic receptor subtypes to ion channels: experiments on neuroblastoma hybrid cells

scientific article published on 01 December 1993

Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells.

scientific article

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.

scientific article published on 28 August 2015

Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.

scientific article published on 28 June 2007

Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum

scientific article published on 26 December 2016

Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.

scientific article

Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism

scientific article

Design and Synthesis of Cyclic ADP‐4‐Thioribose as a Stable Equivalent of Cyclic ADP‐Ribose, a Calcium Ion‐Mobilizing Second Messenger

scientific article published on May 13, 2013

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose

scientific article (publication date: 2014)

Dissection of bradykinin-evoked responses by buffering intracellular Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells

scientific article published on November 1, 1992

Distinct induction of c-fos mRNA in NG108-15 cells transfected with muscarinic m1 and m3 receptors.

scientific article published in July 1994

Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages

scientific article published on September 2004

Effects of electrical lesions of the medial preoptic area and the ventral pallidum on mate-dependent paternal behavior in mice

scientific article published on 8 April 2014

Effects of toki-shakuyaku-san (Tsumura TJ-23) on electrical activity in neuroblastoma cells and frog neuromuscular junctions

scientific article published on October 1, 1992

Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors.

scientific article published in February 1998

Endothelin induces phosphoinositide metabolite-dependent cellular responses in NG108-15 hybrid cells

scientific article published on 01 December 1993

Enhanced acetylcholine secretion in neuroblastoma x glioma hybrid NG108-15 cells transfected with rat choline acetyltransferase cDNA

scientific article published on December 21, 1992

Enhanced brain signal variability in children with autism spectrum disorder during early childhood

scientific article published on 21 December 2015

Expression of the Na+ dependent uridine transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes.

scientific article published in May 1993

Genes required for Drosophila nervous system development identified by RNA interference.

scholarly article

Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.

scientific article

Genome-wide analysis by RNA interference of genes that affect Drosophila nervous system development

scientific article published in March 2005

Genotypic m3-Muscarinic Receptors Preferentially Inhibit M-currents in DNA-transfected NG108-15 Neuroblastoma x Glioma Hybrid Cells.

scientific article

Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila

scientific article published on November 2006

Induction of interleukin-6 in dorsal root ganglion neurons after gradual elongation of rat sciatic nerve.

scientific article published in September 2005

Induction of tumor necrosis factor-alpha in Schwann cells after gradual elongation of rat sciatic nerve.

scientific article published in November 2005

Inositol 1,4,5-trisphosphate formation and ryanodine-sensitive oscillations of cytosolic free Ca2+ concentrations in neuroblastoma x fibroblast hybrid NL308 cells expressing m2 and m4 muscarinic acetylcholine receptor subtypes

scientific article published on 01 January 1995

Inositol trisphosphate/Ca2+ as a major signal transduction pathway from bradykinin receptors

scientific article published on 01 January 1993

Inositol trisphosphate/calcium-dependent acetylcholine release evoked by bradykinin in NG108-15 rodent hybrid cells.

scientific article published on January 1991

Inositol-1,3,4,5-tetrakisphosphate binding sites in control and ras-transformed NIH/3T3 fibroblasts.

scientific article published on October 1997

Integrative neurochemistry and neurobiology of social recognition and behavior analyzed with respect to CD38-dependent brain oxytocin secretion.

scientific article published on January 2013

Intracellular calcium elevation induced by extracellular application of cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15 neuronal cells with or without exogenous expression of human oxytocin receptors.

scientific article

Ion selectivity of Ba2+ inward current oscillations in ras-transformed fibroblasts that elicit cytoplasmic Ca2+ oscillations by bradykinin

scientific article published on May 29, 1992

K+ channels: their function and structure in NG-108-15 neuroblastoma cells

scientific article published on April 1, 1992

KCR1, a Membrane Protein That Facilitates Functional Expression of Non-inactivating K+ Currents Associates with Rat EAG Voltage-dependent K+Channels

scientific article published on September 4, 1998

Lateralized theta wave connectivity and language performance in 2- to 5-year-old children.

scientific article published in October 2011

Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice

scientific article

Localization of B2 bradykinin receptor mRNA in the rat retina and sclerocornea

scientific article published on 01 December 1999

Long QT syndrome and associated gene mutation carriers in Japanese children: results from ECG screening examinations.

scientific article published on 21 September 2009

Measurement of receptor-operated Ca2+ influx by microspectrofluometry combined with the whole-cell patch clamp technique

scientific article published on October 1, 1997

Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture

scientific article published on 01 February 2000

Microheterogeneity in heteromultimeric assemblies formed by Shaker (Kv1) and Shaw (Kv3) subfamilies of voltage-gated K+ channels.

scientific article published in September 1995

Mouse B2 bradykinin receptor gene maps to distal chromosome 12

scientific article published on 01 May 1995

Muscarinic acetylcholine receptor subtypes in the human iris.

scientific article

Neurotransmitter release: vacuolar ATPase V0 sector c-subunits in possible gene or cell therapies for Parkinson's, Alzheimer's, and psychiatric diseases.

scientific article published on 11 June 2016

Neurovascular coupling in the human somatosensory cortex: a single trial study

scientific article published in December 2010

Nicotinamide-adenine dinucleotide regulates muscarinic receptor-coupled K+ (M) channels in rodent NG108-15 cells.

scientific article published in January 1995

Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane.

scientific article

Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: a case-control study in a Japanese population and functional analysis.

scientific article published on July 2013

Overexpression of choline acetyltransferase reconstitutes discrete acetylcholine release in some but not all synapse formation-defective neuroblastoma cells

scientific article published on January 1, 1995

Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission

scientific article

Overexpression of rat synapsins in NG108-15 neuronal cells enhances functional synapse formation with myotubes

scientific article published on 01 January 1999

Oxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics.

scientific article

Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study

scientific article

Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice.

scientific article published on 05 January 2010

Pairmate-dependent pup retrieval as parental behavior in male mice

scientific article

Participation of a Proton-Cotransporter, MCT1, in the Intestinal Transport of Monocarboxylic Acids

scientific article published on September 14, 1995

Participatory Art Activities Increase Salivary Oxytocin Secretion of ASD Children

scientific article published on 27 September 2020

Phosphoinositide-dependent ion channel and secretion in neuron-like cells

scientific article published on February 1, 1991

Phosphoinositides and synaptic function in NG108-15 neuroblastoma x glioma hybrid cells

scientific article published on January 1, 1991

Potassium channels cloned from neuroblastoma cells display slowly inactivating outward currents in Xenopus oocytes.

scientific article published in May 1992

Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG.

scientific article published in August 2004

Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels.

scientific article

RNA interference screen to identify genes required for Drosophila embryonic nervous system development.

scholarly article

Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways

scientific article (publication date: 2003)

Reduced long-range functional connectivity in young children with autism spectrum disorder.

scientific article

Reproductive experience affects parental retrieval behaviour associated with increased plasma oxytocin levels in wild-type and CD38-knockout mice.

scientific article published in November 2011

Salivary oxytocin concentrations in seven boys with autism spectrum disorder received massage from their mothers: a pilot study.

scientific article

Scopolamine modulates paternal parental retrieval behavior in mice induced by the maternal mate

scientific article published on May 10, 2013

Slow inactivation conserved in heteromultimeric voltage-dependent K+ channels between Shaker (Kv1) and Shaw (Kv3) subfamilies.

scientific article published in September 1995

Social Interaction Improved by Oxytocin in the Subclass of Autism with Comorbid Intellectual Disabilities

scientific article published on 22 February 2019

Sodium channel mRNAs I, II and III in the CNS: cell-specific expression.

scientific article

Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.

scientific article

Somatosensory evoked field in response to visuotactile stimulation in 3- to 4-year-old children

scientific article published on 24 March 2014

Spatiotemporal frequency characteristics of cerebral oscillations during the perception of fundamental frequency contour changes in one-syllable intonation.

scientific article published on 21 March 2012

Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells.

scientific article published on February 1996

Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells.

scientific article published on June 2003

Sulfhydryl modification inhibits K+ (M) current with kinetics close to acetylcholine in rodent NG108-15 cells.

scientific article published in January 1997

The Predominant Contribution of Oligopeptide Transporter PepT1 to Intestinal Absorption of β-Lactam Antibiotics in the Rat Small Intestine

scientific article published on August 1, 1997

The brain's response to the human voice depends on the incidence of autistic traits in the general population

scientific article

The roles of oxytocin and CD38 in social or parental behaviors.

scientific article published on January 2012

Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles.

scientific article published on 27 March 2010

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.

scientific article published on May 2010

Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography.

scientific article published on 12 January 2015

Whole-cell analysis of NGK2 (mKv3.1a) K+ channels stably expressed in mouse fibroblast cells

scientific article published on 01 September 1995

[About K+ channels]

scientific article published on 01 November 1995

[Cellular reactions after stimulation of receptors: research model for evaluation of effects and action mechanisms of drugs for discovery of innovative drugs]

scientific article published on 01 September 1993

[Classification of cell-surface receptors based on molecular structures and functions]

scientific article published on 01 July 1998

[Cyclic ADP-ribose as a second messenger--intramembrane signal transduction from receptors to ADP-ribosyl cyclase]

scientific article published on 01 November 1998

[K+ channel]

scientific article published on 01 February 1997

cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter.

scientific article published on December 1995