List of works by María L López-Rodríguez

1-[omega-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5- pyrrolidinediones as 5-HT1A receptor ligands: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity.

scientific article published in March 1998

2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.

scientific article published on 27 February 2018

2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.

scientific article

A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration

scientific article published on 16 December 2019

A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity

scientific article published on 8 November 2017

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

scientific article published on 19 June 2019

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

scientific article published on 08 October 2014

A cannabinoid link between mitochondria and memory.

scientific article published on 9 November 2016

A fluorescent probe to unravel functional features of cannabinoid receptor CB1 in human blood and tonsil immune system cells

scientific article published on 9 January 2018

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

scientific article published on 24 January 2017

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

scientific article published on 16 December 2011

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

scientific article published in June 2005

Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis

scientific article published on 7 June 2005

Alpha 1-adrenoceptor reagents. Synthesis of some 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido and 5,6,11,11b-tetrahydro-1H-imidazo[1',5':1,2]pyrido[3,4-b]indole-1,3(2H) -diones

scientific article published on 01 June 1995

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.

scientific article

Arylpiperazine derivatives acting at 5-HT(1A) receptors.

scientific article

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

scientific article

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors

scientific article published on 01 December 1999

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists

scientific article published in October 2002

Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists

scientific article

Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

scientific article published on 01 November 1999

Blocking Ras inhibition as an antitumor strategy

scientific article

CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches

scientific article

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

scientific article (publication date: 3 October 2003)

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.

scientific article published on 12 January 2004

Chemical probes for the recognition of cannabinoid receptors in native systems

scientific article

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

scientific article published on 01 November 1997

Design and synthesis of 2-[4-[4-(m-(ethylsulfonamido)-phenyl) piperazin-1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2-c]imidazole (EF-7412) using neural networks. A selective derivative with mixed 5-HT1A/D2 antagonist properties.

scientific article published in June 1999

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

scientific article

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

scientific article published in October 2003

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

scientific article published in April 2003

Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.

scientific article

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

scientific article published in July 2002

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

scientific article published on 14 May 2010

Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-HT1A Receptor in Native Cells of the Immune System

article

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

scientific article

Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors

scientific article published on 27 June 2011

Development of molecular probes for the human 5-HT(6) receptor.

scientific article published on October 2010

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy

scientific article published on 27 January 2011

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

scientific article

Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

scientific article published on 30 December 2014

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

scientific article published on 3 November 2014

Fine-Tuned Aminal Cleavage: A Concise Route to Differentially Protected Enantiopuresyn-α,β-Diamino Esters

scientific article published on 01 March 2004

First pharmacophoric hypothesis for 5-HT7 antagonism

scientific article published on 01 May 2000

Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells

scientific article published on March 2007

Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin

scientific article published in June 2003

Ligand chain length drives activation of lipid G protein-coupled receptors

scientific article published on 17 May 2017

Mitochondrial CB₁ receptors regulate neuronal energy metabolism

scientific article published on 4 March 2012

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

scientific article published on 27 July 2018

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

scientific article published on 10 January 2017

Neurochemical effects of the endocannabinoid uptake inhibitor UCM707 in various rat brain regions.

scientific article published on 23 November 2006

New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.

scientific article published in February 2003

New inhibitors of angiogenesis with antitumor activity in vivo

scientific article published on 4 May 2015

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

scientific article published on 11 November 2011

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

scientific article published on 8 October 2013

New synthetic inhibitors of fatty acid synthase with anticancer activity

scientific article published on 16 May 2012

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

scientific article published on 01 December 2009

Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.

scientific article published on October 2010

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives

scientific article

Preclinical pharmacology of B-20991, a 5-HT1A receptor agonist with anxiolytic activity

scientific article published on 01 March 1998

Reaction of 6-hydroxytetrahydro-beta-carboline-3-carboxylic acids with isocyanates and isothiocyanates

scientific article published on 01 October 1994

Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle

scientific article

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

scientific article (publication date: 11 September 2014)

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity

scientific article published on January 2007

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

scientific article

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

scientific article published in October 1996

Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparis

scientific article published on 01 May 1997

Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment

scientific article published in August 1997

Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed [...]

scientific article

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors

scientific article

Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.

scientific article

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity

scientific article

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

scientific article

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

scientific article published on 8 March 2010

The expression of cannabinoid receptor 1 is significantly increased in atopic patients

scientific article published on 31 January 2014

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

scientific article published on 5 August 2014

The importance of solvation in the design of ligands targeting membrane proteins

article by Angel Gonzalez et al published 2011 in MedChemComm

The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

scientific article published on January 2007

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors.

scientific article published on 21 October 2016

UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide

scientific article published in August 2002

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

scientific article published on 11 July 2005

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