List of works - Federica Vacondio

2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.

scientific article published on 10 April 2009

5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line

scientific article

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

scientific article

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

scientific article

Analysis of illicit dietary supplements sold in the Italian market: identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS

scientific article published on 14 March 2014

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

scientific article published on 19 September 2010

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

scientific article

Antioxidant and cytoprotective activity of indole derivatives related to melatonin.

scientific article

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

scientific article published on 02 December 2019

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability ⬇️

scientific article published on July 21, 2011

Brain pharmacokinetics of non-imidazole biphenyl H3 receptor antagonists: a liquid chromatography/electrospray-mass spectrometry and ex vivo binding study in rats.

scientific article published in July 2012

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.

scientific article

Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction.

scientific article published on 7 October 2014

Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo

scientific article published on 28 September 2020

Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress

scientific article published on 27 July 2006

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

scientific article published on 20 December 2011

Epidermal growth factor receptor irreversible inhibitors: chemical exploration of the cysteine-trap portion.

scientific article published on October 2011

Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities

scientific article published in March 2004

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

scientific article published on 17 February 2012

Liquid chromatography-mass spectrometric method for determination of the non-imidazole H3-receptor antagonist UPR1056 in rat plasma

scientific article published on 06 June 2011

Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.

scientific article published on 11 August 2013

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

scientific article published on 10 May 2012

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands

scientific article published in October 2009

On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships

scientific article published on 28 April 2015

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons

scientific article published on May 2015

Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?

scientific article published on 27 April 2016

Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands

scientific article published on 07 May 2015

Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study

scientific article

Qualitative structure-metabolism relationships in the hydrolysis of carbamates.

scientific article

Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates

scientific article published on 20 May 2017

Structure–property relationships on histamine H3-antagonists: binding of phenyl-substituted alkylthioimidazole derivatives to rat plasma proteins

scientific article published in April 2000

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

scientific article published on 01 January 2000

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

scientific article published on 29 May 2008

Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor.

scientific article

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

scientific article

Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group

scientific article published in January 2003

Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.

scientific article published in April 2006

Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.

scientific article published in February 2004

The role of HB-donor groups in the heterocyclic polar fragment of H3-antagonists. I. Synthesis and biological assays.

scientific article published in September 2003

Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.

scientific article published in April 2003

List of works by Federica Vacondio

2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.

5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

Analysis of illicit dietary supplements sold in the Italian market: identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

Antioxidant and cytoprotective activity of indole derivatives related to melatonin.

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability ⬇️

Brain pharmacokinetics of non-imidazole biphenyl H3 receptor antagonists: a liquid chromatography/electrospray-mass spectrometry and ex vivo binding study in rats.

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.

Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction.

Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo

Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

Epidermal growth factor receptor irreversible inhibitors: chemical exploration of the cysteine-trap portion.

Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

Liquid chromatography-mass spectrometric method for determination of the non-imidazole H3-receptor antagonist UPR1056 in rat plasma

Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands

On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons

Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?

Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands

Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study

Qualitative structure-metabolism relationships in the hydrolysis of carbamates.

Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates

Structure–property relationships on histamine H3-antagonists: binding of phenyl-substituted alkylthioimidazole derivatives to rat plasma proteins

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor.

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group

Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.

Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.

The role of HB-donor groups in the heterocyclic polar fragment of H3-antagonists. I. Synthesis and biological assays.

Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.