Search filters

List of works by Niels Skotte

A fully humanized transgenic mouse model of Huntington disease.

scientific article

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

scientific article published on 18 January 2017

A quantitative method for the specific assessment of caspase-6 activity in cell culture

scientific article (publication date: 2011)

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound

scientific article published on 25 July 2019

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients

scientific article

Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease

scientific article published on 04 March 2019

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

scientific article

Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex

scientific article published on 13 March 2019

Genome-wide association studies identify new interesting loci for late-onset Alzheimer's disease

scientific article published on 20 January 2010

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

scientific article published on 10 February 2014

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

scientific article published on 16 October 2021

Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.

scientific article published on 23 July 2015

Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease

article

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.

scientific article published on 7 August 2014

Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome

scientific article published on 13 May 2020

Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism

scientific article published on 01 May 2018

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

scientific article published on 11 February 2016

Palmitoylation of caspase-6 by HIP14 regulates its activation

scientific article published on 2 December 2016

Personalized gene silencing therapeutics for Huntington disease.

scientific article published on 11 April 2014

Polycystin-1: a key player in hereditary cystic kidney and liver disorders

scientific article published on 23 September 2011

Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin

scientific article

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

scientific article published on 6 March 2018

Reduced gluconeogenesis and lactate clearance in Huntington's disease.

scientific article published on 19 August 2010

Site-specific characterization of endogenous SUMOylation across species and organs.

scientific article published on 25 June 2018

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

scientific article published on 18 September 2013

Paulina is supported by:

About Paulina

Help