List of works - Dumitru Constantin-Teodosiu

A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.

scientific article published on 25 September 2008

A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue

scientific article published on 01 November 1991

A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans.

scientific article published on 17 October 2006

Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise ⬇️

scientific article published on December 1, 1991

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

scientific article published on 21 October 2004

Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans

scientific article published on 03 November 2011

Anaerobic energy production in human skeletal muscle in intense contraction: a comparison of 31P magnetic resonance spectroscopy and biochemical techniques

scientific article published on 01 May 1997

Bicarbonate-induced alkalosis augments cellular acetyl group availability and isometric force during the rest-to-work transition in canine skeletal muscle.

scientific article published in July 2002

Carbohydrate ingestion augments L-carnitine retention in humans

scientific article published on 30 November 2006

Carbohydrate ingestion prior to exercise augments the exercise-induced activation of the pyruvate dehydrogenase complex in human skeletal muscle

scientific article published on 01 September 2000

Carnitine metabolism in human muscle fiber types during submaximal dynamic exercise

scientific article published on 01 March 1996

Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

scientific article published on August 2010

Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.

scientific article

Chronic treatment with the beta(2)-adrenoceptor agonist prodrug BRL-47672 impairs rat skeletal muscle function by inducing a comprehensive shift to a faster muscle phenotype

scientific article published on 14 July 2006

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

scientific article published on 5 January 2017

Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle

scientific article

Dual effects of dichloroacetate on cardiac ischaemic preconditioning in the rat isolated perfused heart.

scientific article

Elevated Free Fatty Acids Attenuate the Insulin-Induced Suppression of PDK4 Gene Expression in Human Skeletal Muscle: Potential Role of Intramuscular Long-Chain Acyl-Coenzyme A

article

Exercise with low muscle glycogen augments TCA cycle anaplerosis but impairs oxidative energy provision in humans.

scientific article published in May 2002

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

scientific article

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones.

scientific article

Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.

scientific article published on February 1996

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance

scientific article published on 31 January 2018

Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

scientific article published on 2 November 2017

Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.

scientific article

Low intensity exercise in humans accelerates mitochondrial ATP production and pulmonary oxygen kinetics during subsequent more intense exercise.

scientific article

Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake.

scientific article published on 15 February 2018

Mitochondrial DNA copy number associates with insulin sensitivity and aerobic capacity, and differs between sedentary, overweight middle-aged males with and without type 2 diabetes

scientific article published on 22 October 2019

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent

scientific article published on 12 June 2017

Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans.

scientific article published on 7 October 2004

New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle

scientific article

Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate

scientific article

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

scientific article published on 31 May 2007

PPARdelta agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction.

scientific article

Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats.

scientific article published on 23 May 2017

Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding-induced muscle insulin resistance.

scientific article published on 23 January 2015

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

scientific article published on 8 October 2012

Phosphocreatine degradation in type I and type II muscle fibres during submaximal exercise in man: effect of carbohydrate ingestion

scientific article

Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle

scientific article published on 01 March 1990

Reduced fat oxidation during high intensity, submaximal exercise: is the availability of carnitine important?

Regulation of human metabolism by hypoxia-inducible factor

scientific article

Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate

scientific article published on October 2013

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

scientific article published on 22 April 2013

Short-term starvation and mitochondrial dysfunction - a possible mechanism leading to postoperative insulin resistance

scientific article published on 17 May 2009

Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans

scientific article published in July 2013

Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

scientific article

Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.

scientific article published on 5 February 2009

TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis.

scientific article published on 15 May 2015

Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats.

scientific article published on 24 January 2008

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

scientific article

The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle.

scientific article published in October 2002

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle

scientific article published on 23 January 2016

The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function

scientific article published on 6 February 2010

The effects of increasing exercise intensity on muscle fuel utilisation in humans

scientific article

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points

scientific article published on 18 August 2018

The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans

scientific article

The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.

scientific article published in November 2002

The tricarboxylic acid cycle in human skeletal muscle: is there a role for nutritional intervention?

scientific article

List of works by Dumitru Constantin-Teodosiu

A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.

A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue

A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans.

Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise ⬇️

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans

Anaerobic energy production in human skeletal muscle in intense contraction: a comparison of 31P magnetic resonance spectroscopy and biochemical techniques

Bicarbonate-induced alkalosis augments cellular acetyl group availability and isometric force during the rest-to-work transition in canine skeletal muscle.

Carbohydrate ingestion augments L-carnitine retention in humans

Carbohydrate ingestion prior to exercise augments the exercise-induced activation of the pyruvate dehydrogenase complex in human skeletal muscle

Carnitine metabolism in human muscle fiber types during submaximal dynamic exercise

Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.

Chronic treatment with the beta(2)-adrenoceptor agonist prodrug BRL-47672 impairs rat skeletal muscle function by inducing a comprehensive shift to a faster muscle phenotype

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle

Dual effects of dichloroacetate on cardiac ischaemic preconditioning in the rat isolated perfused heart.

Elevated Free Fatty Acids Attenuate the Insulin-Induced Suppression of PDK4 Gene Expression in Human Skeletal Muscle: Potential Role of Intramuscular Long-Chain Acyl-Coenzyme A

Exercise with low muscle glycogen augments TCA cycle anaplerosis but impairs oxidative energy provision in humans.

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones.

Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance

Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.

Low intensity exercise in humans accelerates mitochondrial ATP production and pulmonary oxygen kinetics during subsequent more intense exercise.

Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake.

Mitochondrial DNA copy number associates with insulin sensitivity and aerobic capacity, and differs between sedentary, overweight middle-aged males with and without type 2 diabetes

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent

Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans.

New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle

Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

PPARdelta agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction.

Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats.

Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding-induced muscle insulin resistance.

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

Phosphocreatine degradation in type I and type II muscle fibres during submaximal exercise in man: effect of carbohydrate ingestion

Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle

Reduced fat oxidation during high intensity, submaximal exercise: is the availability of carnitine important?

Regulation of human metabolism by hypoxia-inducible factor

Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

Short-term starvation and mitochondrial dysfunction - a possible mechanism leading to postoperative insulin resistance

Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans

Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.

TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis.

Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle.

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle

The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function

The effects of increasing exercise intensity on muscle fuel utilisation in humans

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points

The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans

The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.

The tricarboxylic acid cycle in human skeletal muscle: is there a role for nutritional intervention?