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List of works by Reiji Kannagi

1H-n.m.r. analysis of type-2 chain lacto-gangliosides. Confirmation of structure of a novel cancer-associated fucoganglioside, alpha-NeuAc-(2----6)- beta-D-Galp-(1----4)-beta-D-GlcpNAc-(1----3)-beta-D-Galp-(1----4)-[alp ha-L- Fucp-(1----3)]-beta-D-G

scientific article published on 01 July 1988

6-O-sulfo sialylparagloboside and sialyl Lewis X neo-glycolipids containing lactamized neuraminic acid: synthesis and antigenic reactivity against G159 monoclonal antibody.

scientific article published in March 2005

A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody

scientific article published in Science

A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc

scientific article

A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis.

scientific article

A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.

scientific article published in September 2007

A transgenic mouse line with alpha-1,3/4-fucosyl-transferase cDNA: production and characteristics

scientific article published on 01 December 1995

A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements

scientific article published on 27 January 2016

Adhesion molecules and TGF-beta1 are involved in the peritoneal dissemination of NUGC-4 human gastric cancer cells

scientific article published on 01 March 1997

Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A

scientific article published on 01 September 1991

Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia: clues in the ongoing search for new tumor markers.

scientific article published on 04 December 2009

Anaplasma marginale Outer Membrane Protein A Is an Adhesin That Recognizes Sialylated and Fucosylated Glycans and Functionally Depends on an Essential Binding Domain.

scientific article published on 19 December 2016

Anti-oligosaccharide antibodies as tools for studying sulfated sialoglycoconjugate ligands for siglecs and selectins.

scientific article

Attachment of human colon cancer cells to vascular endothelium is enhanced by N-acetylglucosaminyltransferase V.

scientific article published in January 2004

BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells

scientific article published on 09 February 2020

BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation

scientific article published on 31 August 2018

Biochemical analysis of inhibitory effects of a lymphokine suppressive B-cell factor on the activation process of resting B cells

scientific article published on 01 March 1988

Biochemical demonstration and immunohistochemical localization of calpain in human skin.

scientific article published on April 1986

Blood group A glycolipid (Ax) with globo-series structure which is specific for blood group A1 erythrocytes: one of the chemical bases for A1 and A2 distinction

scientific article published on 01 October 1984

Blood group H antigen with globo-series structure. Isolation and characterization from human blood group O erythrocytes

scientific article published on 01 October 1984

CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.

scientific article published on February 2008

Calpain activates two transglutaminases from porcine skin

scientific article published on 01 January 1988

Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis

scientific article published in May 2004

Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer.

scientific article published on August 1997

Characterization of an epitope (determinant) structure in a developmentally regulated glycolipid antigen defined by a cold agglutinin Fl, recognition of alpha-sialosyl and alpha-L-fucosyl groups in a branched structure.

scientific article published on August 1983

Chemical and apoptotic properties of hydroxy-ceramides containing long-chain bases with unusual alkyl chain lengths.

scientific article

Clinical application of functional glycoproteomics - dissection of glycotopes carried by soluble CD44 variants in sera of patients with cancers.

scientific article

Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9.

scientific article

Concerted mass spectrometry-based glycomic approach for precision mapping of sulfo sialylated N-glycans on human peripheral blood mononuclear cells and lymphocytes.

scientific article published on 26 October 2017

Core 2 GlcNAc modification and megalin ligand-binding activity

scientific article published on 25 October 2007

Core 2 GlcNAc transferase and kidney tubular cell-specific expression.

scientific article published on January 2004

Cross-linking of lipocortin I and enhancement of its Ca2+ sensitivity by tissue transglutaminase

scientific article published on 01 September 1989

Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas--a novel proliferative biomarker for breast cancers with high malignancy.

scientific article

Degradation of neurofilament protein in cerebral ischemia

scientific article published on 01 January 1989

Differentiation-associated changes of glycolipid composition and metabolism in mouse myeloid leukemia cells. Induction of globotriaosylceramide and a galactosyltransferase

scientific article published on 01 September 1983

Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis

scientific article published in 2018

Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas p-selectin does not.

scientific article

Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer

scientific article published on 23 May 2017

Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas.

scientific article

Effect of different physical states of phospholipid substrates on partially purified platelet phospholipase A2 activity

scientific article published on October 5, 1979

Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis

scientific article published on 10 November 2016

Epigenetic silencing of the sulfate transporter gene DTDST induces sialyl Lewisx expression and accelerates proliferation of colon cancer cells.

scientific article published on 11 May 2010

Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers

scientific article published on 01 February 2019

Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

scientific article

Evidence for membrane-associated calpain I in human erythrocytes. Detection by an immunoelectrophoretic blotting method using monospecific antibody

scientific article published on 01 July 1984

Expression of CC-chemokine receptor 7 (CCR7) and CXC-chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma

scientific article published on 28 December 2009

Expression of E-selectin on endothelial cells of small veins in human colorectal cancer

scientific article published on 01 May 1995

Expression of N-acetylglucosamine 6-O-sulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-alpha.

scientific article published on 23 February 2005

Expression of neural cell adhesion molecule in normal gastric mucosa and in gastric carcinoid tumors

scientific article published on 01 January 1994

Expression of sialyl Lewis(X) in rat heart with ischaemia/reperfusion and reduction of myocardial reperfusion injury by a monoclonal antibody against sialyl Lewis(X)

scientific article published on 01 November 1996

F1 alpha: a novel mucin antigen associated with gastric carcinogenesis.

scientific article published in January 1998

FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

scientific article published on 5 October 2017

Fucosylated type-2 chain polylactosamine antigens in human lung cancer

scientific article published on 01 March 1988

Gangliosides and Tumors

scientific article published on 01 January 2018

Generation and characterization of a series of monoclonal antibodies that specifically recognize [HexA(+/-2S)-GlcNAc]n epitopes in heparan sulfate

scientific article published on 07 May 2008

Glycomic mapping of pseudomucinous human ovarian cyst glycoproteins: identification of Lewis and sialyl Lewis glycotopes.

scientific article

Glycosphingolipids as mediators of phenotypic changes associated with development and cancer progression

scientific article published on 01 January 2010

Glycosylation Changes in Cancer

High-performance liquid chromatographic assay of transglutaminase and its application to the purification of human erythrocyte transglutaminase and platelet factor XIII.

scientific article published in June 1987

Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.

scientific article

Human epidermis contains coagulation factor XIII

scientific article published on 01 January 1990

Human hepatocellular carcinoma-associated changes of glycosphingolipids detected by two monoclonal antibodies FH2 and IB9

scientific article published on 01 January 1986

Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M.

scientific article published on March 2007

Hypoxia remodels the composition of the constituent ceramide species of HexCer and Hex2Cer with phytosphingosine and hydroxy fatty acids in human colon cancer LS174T cells

scientific article published on 22 July 2015

Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells.

scientific article published on 9 April 2007

Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells.

scientific article published on March 2006

Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on a subset of skin-homing helper memory T cells.

scientific article

Identification of immuno-reactive lipocortin 1-like molecules in serum and plasma by an enzyme immunoassay for lipocortin 1

scientific article published on 01 March 1992

Immunohistochemical localization of lipocortins in normal and psoriatic human skin

scientific article published on 01 January 1993

Impairment of selectin-mediated leukocyte adhesion to venular endothelium in spontaneously hypertensive rats.

scientific article published on October 1995

Increased expression of integrins by heparin-binding EGF like growth factor in human esophageal cancer cells

scientific article published on 01 April 1996

Increased level of circulating adhesion molecules in the sera of breast cancer patients with distant metastases

scientific article published on 01 June 1997

Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco

scientific article

Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells.

scientific article

Induction of E-selectin expression on vascular endothelium by digestive system cancer cells

scientific article published on 01 April 1996

Induction of sialyl Lewis(X) on the surface of cultured rat vascular endothelial cells and cardiac myocytes by hypoxia/reoxygenation in vitro

scientific article published on 01 November 1996

Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis.

scientific article published on 15 March 2018

Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes

scientific article

Introduction to special issue: 'emerging roles of siglecs in health and disease'.

scientific article published in September 2014

Involvement of adhesion molecules in metastasis of SW1990, human pancreatic cancer cells

scientific article published on 01 February 1998

KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing

scientific article published on 18 December 2012

Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice

scientific article published in October 2009

Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count

scientific article published on 19 April 2011

Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers.

scientific article

Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ.

scientific article published on 31 October 2014

Mobilization of arachidonic acid from phosphatidylethanolamine fraction to phosphatidylcholine fraction in platelets

scientific article published on 01 September 1980

Modulation of MUC1 mucin as an escape mechanism of breast cancer cells from autologous cytotoxic T-lymphocytes.

scientific article published on May 2001

Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.

scientific article published on 21 February 2006

Molecular diversity of calpastatin in mammalian organs

scientific article published on 01 August 1984

Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-The Warburg effect revisited.

scientific article published in January 2004

NMR analysis of novel ganglioside GM4 analogues containing de-N-acetyl and lactamized sialic acid: probes for searching new ligand structures for human L-selectin

NMR structure elucidation of cyclic sialyl 6-sulfo Lewis x, a biologically dormant form of L-selectin ligand

P- and E-selectins recognize sialyl 6-sulfo Lewis X, the recently identified L-selectin ligand.

scientific article

P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction

scientific journal article

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer.

scientific article published in December 2001

Papillary serous carcinoma of the peritoneum in women. A clinicopathologic and immunohistochemical study

scientific article published on 01 August 1995

Parietal cell autoantigens involved in neonatal thymectomy-induced murine autoimmune gastritis. Studies using monoclonal autoantibodies

scientific article published on 01 August 1989

Phospholipid-deacylating enzymes of rabbit platelets ⬇️

scientific article published on September 1, 1979

Platelet factor XIII is activated by calpain

scientific article published on 01 April 1987

Possible involvement of transglutaminase in endocytosis and antigen presentation

scientific article published on 01 January 1985

Preparation of mouse-human chimeric antibody to an embryonic carbohydrate antigen, Lewis Y.

scientific article published on January 1993

Production of monoclonal antibody to human esophageal cancer cell line.

scientific article published on March 1990

Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes

scientific article published on 07 September 2006

Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway

scientific article

Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS.

scientific article

Regulation of mouse kidney tubular epithelial cell-specific expression of core 2 GlcNAc transferase

scientific article published on 01 February 2001

Regulation of selectin binding activity by cyclization of sialic acid moiety of carbohydrate ligands on human leukocytes.

scientific article

Regulatory roles of carbohydrate ligands for selectins in the homing of lymphocytes.

scientific article

Reversed distribution of calpains and calpastatin in human pituitary gland and selective localization of calpastatin in adrenocorticotropin-producing cells as demonstrated by immunohistochemistry.

scientific article published in August 1986

Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells.

scientific article published on 26 March 2012

Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation

scientific article published on 27 July 2019

SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum.

scientific article published on 15 May 2006

SHP-2-Erk signaling regulates concanavalin A-dependent production of TIMP-2

scientific article published on 04 August 2006

SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES Cells

scientific article published on 10 January 2020

Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.

scientific article published on 14 January 2004

Sequential change of carbohydrate antigen associated with differentiation of murine leukemia cells: i-I antigenic conversion and shifting of glycolipid synthesis.

scientific article published on May 1983

Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure.

scientific article

Sialic acid cyclization of human Th homing receptor glycan associated with recurrent exacerbations of atopic dermatitis

scientific article published on 8 October 2012

Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters

scientific article published on 20 June 2019

Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans

scientific article published on 26 May 2015

Significance of 2-3 and 2-6 sialylation of Lewis a antigen in pancreas cancer

scientific article published on 01 February 1988

Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes.

scientific article published on 10 October 2008

Spatially and temporally regulated expression of N-acetylglucosamine-6-O-sulfotransferase during mouse embryogenesis.

scientific article published in September 1999

Specific detection of sialyl Lewis X determinant carried on the mucin GlcNAcbeta1-->6GalNAcalpha core structure as a tumor-associated antigen.

scientific article published on June 1998

Specific expression of a complex sialyl Lewis X antigen on high endothelial venules of human lymph nodes: possible candidate for L-selectin ligand

scientific article published on 01 May 1993

Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation.

scientific article published in January 2016

Suppression of sialyl Lewis X expression and E-selectin-mediated cell adhesion in cultured human lymphoid cells by transfection of antisense cDNA of an alpha1-->3 fucosyltransferase (Fuc-T VII).

scientific article published on December 1996

Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells

scientific article published in Scientific Reports

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides

scientific article

Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.

scientific article published on September 2005

Systematic analyses of free ceramide species and ceramide species comprising neutral glycosphingolipids by MALDI-TOF MS with high-energy CID.

scientific article

TNF-alpha increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans.

scientific article published on October 2002

TNFα enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands

scientific article

The First Total Synthesis of 6-Sulfo-de-N-acetylsialyl Lewis(x) Ganglioside: A Superior Ligand for Human L-Selectin

scientific article

The common structure in fucosyllactosaminolipids accumulating in human adenocarcinomas, and its possible absence in normal tissue

scientific article published on 01 November 1982

Tissue distribution of 2-3 and 2-6 sialyl Lewis A antigens and significance of the ratio of two antigens for the differential diagnosis of malignant and benign disorders of the digestive tract

scientific article published on 01 March 1991

Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element

scientific article (publication date: May 2003)

Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition.

scientific article

Transglutaminase activity during the differentiation of macrophages

scientific article published on 01 March 1982

Two different molecular species of pig calpastatin. Structural and functional relationship between 107 kDa and 68 kDa molecules.

scientific article published on April 1986

Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.

scientific article

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