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List of works by Valentina Gandin

(99m)Tc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study.

scientific article published on 31 March 2013

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

scientific article published on 07 December 2016

A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: a Dual-Acting Weapon for Targeting DNA in Cancer Cells

scientific article published in 2018

A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines.

scientific article

A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation.

scientific article published on August 2010

A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling

scientific article

A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

scientific article

Advances in copper complexes as anticancer agents

scientific article published on 08 October 2013

An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties

scientific article published on 15 March 2017

An unsymmetric cisplatin-based Pt(iv) derivative containing 2-(2-propynyl)octanoate: a very efficient multi-action antitumor prodrug candidate

scientific article published on 6 October 2017

Anticancer activity of a series of copper(II) complexes with tripodal ligands.

scientific article

Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action

scientific article published on 23 November 2020

Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid

scientific article

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

scientific article published on 12 August 2015

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

scientific article

Cell biology. Trans-HSF1 express

scientific article published in July 2013

Chemistry and biological activity of platinum amidine complexes

scientific article published on 31 May 2011

Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy

scientific article published on 22 August 2007

Co-translational mechanisms of quality control of newly synthesized polypeptides

scientific article

Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines.

scientific article published on 22 June 2010

Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity.

scientific article

Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.

scientific article published on 18 December 2015

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

scientific article

DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relationships.

scientific article

DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex

scientific article

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

scientific article published on 22 April 2013

Distinct translational control in CD4+ T cell subsets

scientific article

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

scientific article published on 15 February 2018

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

scientific article published on 01 May 2018

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression.

scientific article published on July 2012

Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.

scientific article published on 10 December 2008

Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.

scientific article

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates

scientific article

Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila

scientific article

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

scientific article published on 10 September 2008

Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)4]PF6 and [Au(P)4]PF6 (P = thp or PTA) Anticancer Complexes.

scientific article

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

scientific article published on 28 October 2019

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

scientific article

Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways

scientific article

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapour synthesis are electively internalized in a pancreatic adenocarcinoma cell line expressing GLUT1 transporter

scientific article

Homoleptic phosphino copper(I) complexes with in vitro and in vivo dual cytotoxic and anti-angiogenic activity

scientific article published on 20 July 2015

Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin.

scientific article

In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxiliary monodentate phosphine ligands.

scientific article published on 15 May 2014

In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.

scientific article published on 6 February 2008

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands.

scientific article published on 5 November 2010

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase

scientific article published on 9 January 2014

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

scientific article published on 22 December 2006

Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)4][PF6].

scientific article published on 8 July 2016

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications.

scientific article published on 11 March 2011

JNK inhibition arrests cotranslational degradation

scientific article published on 30 March 2010

Largen: a molecular regulator of mammalian cell size control

scientific article

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

scientific article (publication date: 2015)

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems

scientific article published in 2012

Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand.

scientific article published on 2 May 2014

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

scientific article published on 14 July 2018

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

scientific article published on 10 November 2011

Neutral and charged phosphine/scorpionate copper(I) complexes: effects of ligand assembly on their antiproliferative activity.

scientific article published on 23 November 2012

Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(II) complexes. Syntheses, biological activity and XAS studies

scientific article published on 28 June 2011

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

scientific article published on 17 July 2014

Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy

scientific article

Novel imino thioether complexes of platinum(II): synthesis, structural investigation, and biological activity

scientific article published on 6 May 2013

Novel mixed-ligand copper(I) complexes: role of diimine ligands on cytotoxicity and genotoxicity

scientific article published on 10 September 2013

Novel triazolium based 11(th) group NHCs: synthesis, characterization and cellular response mechanisms.

scientific article published on 20 November 2015

Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

scientific article published on 08 May 2018

Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position

scientific article published on 11 July 2016

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

scientific article

Photoreactivity of 5-fluorouracil under UVB light: photolysis and cytotoxicity studies.

scientific article published on 15 July 2011

Phthalates and heavy metals as endocrine disruptors in food: A study on pre-packed coffee products

scientific article published on 17 May 2017

Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal

scientific article published on 05 December 2019

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.

scientific article published in December 2017

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

scientific article published on 27 March 2020

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale

scientific article published on 17 May 2014

Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation.

scientific article published on 6 April 2011

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

scientific article published on 15 January 2016

RACK1 Function in Cell Motility and Protein Synthesis.

scientific article published on September 2013

Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

scientific article

Role of zinc trafficking in male fertility: from germ to sperm

scientific article published on 25 April 2014

S6K1 plays a critical role in early adipocyte differentiation

scientific article

Selenium compounds as therapeutic agents in cancer.

scientific article published on 16 October 2014

Selenium induces a multi-targeted cell death process in addition to ROS formation

scientific article

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.

scientific article published on 7 May 2015

Sesquiterpene rich essential oil from Nepalese Bael tree (Aegle marmelos (L.) Correa) as potential antiproliferative agent

scientific article published on 11 July 2019

Syntheses and Biological Studies of Cu(II) Complexes Bearing Bis(pyrazol-1-yl)- and Bis(triazol-1-yl)-acetato Heteroscorpionate Ligands.

scientific article published on 7 May 2019

Syntheses and biological studies of nitroimidazole conjugated heteroscorpionate ligands and related Cu(I) and Cu(II) complexes

scientific article published on 19 July 2018

Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist

scientific article published on 09 April 2020

Synthesis and biological activity of ester- and amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes

scientific article

Synthesis and characterization of azolate gold(I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents

scientific article

Synthesis and in vitro antitumor activity of water soluble sulfonate- and ester-functionalized silver(I) N-heterocyclic carbene complexes

scientific article published on 24 September 2013

Synthesis and structural characterization of copper(I) complexes bearing N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA): cytotoxic activity evaluation of a series of water soluble Cu(I) derivatives containing PTA, PTAH and mPTA ligands

scientific article published on 13 September 2009

Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones

scientific article published on 17 April 2020

Synthesis, characterization and cytotoxic activity of novel copper(II) complexes with aroylhydrazone derivatives of 2-Oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde.

scientific article published in February 2018

Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine.

scientific article published on 23 March 2011

Synthesis, characterization and in vitro and in vivo anticancer activity of Pt(iv) derivatives of [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)]

scientific article published on 01 May 2017

Synthesis, characterization, and biological activity of platinum II, III, and IV pivaloamidine complexes

scientific article

Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours

scientific article

Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand

scientific article published on December 2006

Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily.

scientific article

The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexes

scientific article published on 01 June 2010

Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors.

scientific article published on 24 October 2017

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift

scientific article published on 29 May 2009

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance.

scientific article

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

scientific article published on 24 October 2012

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

scientific article published on 4 April 2016

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

scientific article

trans,cis,cis-bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a prodrug candidate for the treatment of oxaliplatin-refractory colorectal cancer

scientific article published on 8 April 2014

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