List of works - Adam J Mead

A British Society for Haematology Guideline on the diagnosis and management of chronic myeloid leukaemia

scientific article published on 30 July 2020

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

scientific article

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

scientific article published on 25 November 2021

Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication

scientific article

Adult idiopathic thrombocytopenic purpura

scientific article

Allogeneic stem cell transplantation for myelofibrosis in 2012.

scientific article published on 29 March 2012

Application of single-cell genomics in cancer: promise and challenges

scientific article

CD34+CD19−CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

scientific article published in 2022

Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis

scientific article published on 16 January 2018

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells

Clinical potential of pacritinib in the treatment of myelofibrosis

scientific article

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

scientific article published on 01 January 2011

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

scientific article published in July 2008

Dicer is selectively important for the earliest stages of erythroid development.

scientific article

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

scientific article published on 04 April 2016

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.

scientific article

Equivalence of BCSH and WHO diagnostic criteria for ET.

scientific article published on 5 May 2017

Equivalence of BCSH and WHO diagnostic criteria for ET.

scientific article published on 29 November 2016

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

scientific article published on 3 February 2014

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

scientific article published in February 2018

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

scientific article published on 02 December 2021

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

scientific article published on 24 April 2007

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

scientific article published on 30 May 2013

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

scientific article

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

scientific article published on 04 July 2016

Guideline for the diagnosis and management of myelofibrosis.

scientific article published in June 2012

Guideline for the investigation and management of eosinophilia.

scientific article

HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning

scientific article published on 6 April 2010

Hippocampal and cortical G protein (Gsα, Goα and Gi2α) mRNA expression after electroconvulsive shock or lithium carbonate treatment

scientific article published on 01 June 1996

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

scientific journal article

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

scientific article published on 27 March 2013

In utero origin of myelofibrosis presenting in adult monozygotic twins

scientific article published on 30 May 2022

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

scientific article published on 03 October 2016

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells

scientific article published on 19 September 2013

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

scientific article published on 12 September 2017

Modification of British Committee for Standards in Haematology diagnostic criteria for essential thrombocythaemia

scientific article published on 17 June 2014

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model

scientific article published on 9 February 2012

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

scientific article published on 15 May 2014

Myeloproliferative neoplasm stem cells.

scientific article published on 3 February 2017

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

scientific article

Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial

scientific article

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

scientific article published on 04 November 2020

Persistent malignant stem cells in del(5q) myelodysplasia in remission

scientific article

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

scientific article

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

scientific article published on 11 August 2013

Practical management of patients with myelofibrosis receiving ruxolitinib

scientific article

Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study

scientific article published on 24 May 2020

Response to ruxolitinib in patients with intermediate-1-, intermediate-2-, and high-risk myelofibrosis: results of the UK ROBUST Trial

scientific article

Ruxolitinib is effective in patients with intermediate-1 risk myelofibrosis: a summary of recent evidence

scientific article published on 27 July 2016

Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide.

scientific article published on 9 August 2017

Single cell analysis of normal and leukemic hematopoiesis

scientific article published on 29 August 2017

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

scientific article published on 24 March 2016

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways

scientific article published on 3 May 2016

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

scientific article

Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide

scientific article published on 07 August 2020

Studying epigenomics in single cells: what is feasible and what can we learn?

scientific article published on 08 December 2015

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

scientific article published on 19 February 2012

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

scientific article

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

scientific article published on 04 October 2019

Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012.

scientific article published on 25 June 2014

VALERIE: Visual-based inspection of alternative splicing events at single-cell resolution

scientific article published on 08 September 2020

List of works by Adam J Mead

A British Society for Haematology Guideline on the diagnosis and management of chronic myeloid leukaemia

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication

Adult idiopathic thrombocytopenic purpura

Allogeneic stem cell transplantation for myelofibrosis in 2012.

Application of single-cell genomics in cancer: promise and challenges

CD34+CD19−CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells

Clinical potential of pacritinib in the treatment of myelofibrosis

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

Dicer is selectively important for the earliest stages of erythroid development.

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.

Equivalence of BCSH and WHO diagnostic criteria for ET.

Equivalence of BCSH and WHO diagnostic criteria for ET.

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

Guideline for the diagnosis and management of myelofibrosis.

Guideline for the investigation and management of eosinophilia.

HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning

Hippocampal and cortical G protein (Gsα, Goα and Gi2α) mRNA expression after electroconvulsive shock or lithium carbonate treatment

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

In utero origin of myelofibrosis presenting in adult monozygotic twins

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

Modification of British Committee for Standards in Haematology diagnostic criteria for essential thrombocythaemia

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Myeloproliferative neoplasm stem cells.

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

Persistent malignant stem cells in del(5q) myelodysplasia in remission

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

Practical management of patients with myelofibrosis receiving ruxolitinib

Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study

Response to ruxolitinib in patients with intermediate-1-, intermediate-2-, and high-risk myelofibrosis: results of the UK ROBUST Trial

Ruxolitinib is effective in patients with intermediate-1 risk myelofibrosis: a summary of recent evidence

Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide.

Single cell analysis of normal and leukemic hematopoiesis

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide

Studying epigenomics in single cells: what is feasible and what can we learn?

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012.

VALERIE: Visual-based inspection of alternative splicing events at single-cell resolution