Search filters

List of works by Peter B Bitterman

A novel zebrafish embryo xenotransplantation model to study primary human fibroblast motility in health and disease.

scientific article

A scalable 3D tissue culture pipeline to enable functional therapeutic screening for pulmonary fibrosis

scientific article published on 16 November 2021

Accurate quantification of cells recovered by bronchoalveolar lavage

scientific article published on 01 October 1984

Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.

scientific article published on 14 July 2009

Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

scientific article published in Nature

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

scientific article published on June 2004

Acute lung injury. A transgenic murine model of intra-alveolar fibrosis

scientific article published on 01 March 1994

Acute lung injury. Pathogenesis of intraalveolar fibrosis ⬇️

scientific article published on August 1, 1991

Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest

scientific article published on 21 May 2007

Alveolar epithelial cells regulate the induction of endothelial cell apoptosis

scientific article published on 01 October 1994

Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung

scientific article published on August 1984

Alveolar macrophages in idiopathic pulmonary fibrosis have glucocorticoid receptors, but glucocorticoid therapy does not suppress alveolar macrophage release of fibronectin and alveolar macrophage derived growth factor

scientific article published on 01 September 1984

Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells

scientific article published on February 2016

Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB.

scientific article published on 22 May 2003

Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.

scientific article

Asbestos stimulates alveolar macrophages to release a factor causing human lung fibroblasts to replicate

scientific article published on 01 July 1981

Attacking a Nexus of the Oncogenic Circuitry by Reversing Aberrant eIF4F-Mediated Translation ⬇️

scientific article published on May 1, 2012

Bronchoalveolar Lavage Fluid Protein Expression in Acute Respiratory Distress Syndrome Provides Insights into Pathways Activated in Subjects with Different Outcomes.

scientific article published on 7 August 2017

Calcium-binding protein S100A4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis

scientific article published on 22 May 2017

Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype ⬇️

scientific article published on July 6, 2012

Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010

scientific article

Characterization of the lower respiratory tract inflammation of nonsmoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts

scientific article published on 01 December 1987

Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells

scientific article (publication date: August 2005)

Colchicine suppresses the release of fibroblast growth factors from alveolar macrophages in vitro. The basis of a possible therapeutic approach ot the fibrotic disorders

scientific article published on 01 January 1988

Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1

scientific article published in February 2008

Correlation of regional emphysema and lung cancer: a lung tissue research consortium-based study.

scientific article published on May 2014

Cyclosporine A toxicity presenting with acute cerebellar edema and brainstem compression. Case report

scientific article published on 01 June 1995

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP

scientific article

Dicer1 Deficiency in the IPF Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis.

scientific article published on 26 March 2018

Distinct Cancer-Promoting Stromal Gene Expression Depending on Lung Function

scientific article published on 01 August 2019

Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure

scientific article published on 24 January 2014

Evidence for chronic inflammation as a component of the interstitial lung disease associated with progressive systemic sclerosis.

scientific article published on April 1985

Expression of the transferrin receptor gene during the process of mononuclear phagocyte maturation

scientific article published on 01 February 1986

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein.

scientific article published on 31 March 2008

Extracellular matrix as a driver of progressive fibrosis

scientific article published on 02 January 2018

Extracellular matrix in lung development, homeostasis and disease

scientific article published on 7 March 2018

Failure of lung repair following acute lung injury. Regulation of the fibroproliferative response (Part 1).

scientific article published in September 1990

Failure of lung repair following acute lung injury. Regulation of the fibroproliferative response (Part 2)

scientific article published on 01 October 1990

Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members

scientific article published on 01 May 1986

Fibroblast-Matrix Cross-Talk in Idiopathic Pulmonary Fibrosis: Cross-Links at the Crossroads

scientific article published on 01 May 2018

Fibroproliferative disorders.

scientific article published on March 1991

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

scientific article published on 03 March 2014

Fibrotic myofibroblasts manifest genome-wide derangements of translational control

scientific article

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report

scientific article published on January 2014

Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

scientific article

Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells.

scientific article published on 17 September 2010

Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes

scientific article published on 03 August 2007

Hyperplasia of type II pneumocytes in acute lung injury. Cytologic findings of sequential bronchoalveolar lavage

scientific article published on 01 May 1992

IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity

scientific article published on 31 August 2017

Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis.

scientific article published on 13 March 2014

Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis

scientific article published on 01 October 1994

Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.

scientific article

Inhibition of mesothelioma cell growth in vitro by doxycycline

scientific article published on 01 August 2001

Inhibition of oncogenic cap-dependent translation by 4EGI-1 reduces growth, enhances chemosensitivity and alters genome-wide translation in non-small cell lung cancer

scientific article published on 12 November 2018

Is there a fibrotic gene?

scientific article published on 01 October 1980

KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT

scientific article published on 01 May 2000

Lovastatin induces apoptosis in malignant mesothelioma cells.

scientific article published on May 1998

Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders.

scientific article published in January 1999

Low-frequency positive-pressure ventilation with extracorporeal carbon dioxide removal

scientific article published on 01 February 1990

Mechanisms of alveolar fibrosis after acute lung injury

scientific article published on December 1, 1990

Mechanisms of alveolar fibrosis following acute lung injury. Presence of angiogenesis bioactivity in the lower respiratory tract

scientific article published on 01 March 1991

Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis.

scientific article published in November 2002

Molecular targeted therapy in lung cancer.

scientific article published on October 2012

Molecular targets in drugs discovery in idiopathic pulmonary fibrosis. Work in progress.

scientific article

Multi-omic molecular profiling of lung cancer in COPD

scientific article published on 04 July 2018

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract.

scientific article published on 23 September 2008

Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1 ⬇️

scientific article published on December 1, 1984

Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation

scientific article

Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor ⬇️

scientific article published on November 1, 1992

Paraquat-induced pulmonary fibrosis. Role of the alveolitis in modulating the development of fibrosis

scientific article published on 01 January 1984

Pathogenesis of fibrosis in acute lung injury ⬇️

scientific article published on June 22, 1992

Pathogenesis of pulmonary fibrosis: platelet-derived growth factor precedes structural alterations in the Hermansky-Pudlak syndrome

scientific article published on 01 April 1994

Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts

scientific article

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

scientific article published on 9 June 2008

Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases.

scientific article

Protein expression profile of rat type two alveolar epithelial cells during hyperoxic stress and recovery

scientific article

Proteome Profiling in Lung Injury after Hematopoietic Stem Cell Transplantation

scientific article published on 04 May 2016

Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors

scientific article

Pulmonary oxygen toxicity. Bronchoalveolar lavage demonstration of early parameters of alveolitis

scientific article published on 01 May 1983

Pulmonary oxygen toxicity. Early reversible changes in human alveolar structures induced by hyperoxia

scientific article published on 01 October 1983

Rebuilding the injured lung.

scientific article published on March 2015

Reemergence of hedgehog mediates epithelial-mesenchymal crosstalk in pulmonary fibrosis

scientific article published in April 2015

Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis

scientific article published on 10 January 2019

Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1

scientific journal article

Regulatory element identification in subsets of transcripts: comparison and integration of current computational methods.

scientific article published on 24 June 2009

Repair after acute lung injury.

scientific article

Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature.

scientific article

Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts.

scientific article published on 15 July 2004

Role of fibronectin as a growth factor for fibroblasts.

scientific article

Role of fibronectin in fibrotic lung disease. A growth factor for human lung fibroblasts

scientific article published on 01 May 1983

Role of mesenchymal cell death in lung remodeling after injury.

scientific article

Safety of bronchoalveolar lavage in the critically ill, mechanically ventilated patient

scientific article published on 01 December 1991

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells.

scientific article published on 9 April 2014

Spontaneous release of interleukin-2 by lung T lymphocytes in active pulmonary sarcoidosis

scientific article published on 01 April 1983

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP.

scientific article published in April 2005

TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels.

scientific article

Telomerase and telomere length in pulmonary fibrosis.

scientific article published on August 2013

The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide

scientific article published on September 1997

The lung matrix and inflammation: Part II. Biochemical and molecular mechanisms of fibrogenesis: implications for environmental lung disease

scientific article published on 01 October 1988

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

scientific article published on 18 November 2002

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency

scientific article

Translational control of cell fate: from integration of environmental signals to breaching anticancer defense.

scientific article published on 15 March 2012

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

scientific article published on November 1996

Translational control of the antiapoptotic function of Ras.

scientific article

Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation.

scientific article

eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

scientific article

eIF4E-mediated translational control of cancer incidence.

scientific article published on 28 September 2014

Paulina is supported by:

About Paulina

Help