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List of works by Leo E Otterbein

'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

scientific article published on January 2004

Activation of peroxisome proliferator-activated receptor γ prolongs islet allograft survival

scientific article published on 28 March 2012

An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis ⬇️

scientific article published on March 28, 2011

Autoantibodies in patients with chronic obstructive pulmonary disease

scientific article

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

scientific article

Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation

scientific article published on January 2014

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.

scientific article published on 4 May 2017

Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation

scientific article published on 8 August 2005

Biliverdin administration protects against endotoxin-induced acute lung injury in rats

scientific article

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase ⬇️

scientific article published on October 31, 2011

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

scientific article published on 9 May 2014

Biliverdin protects the functional integrity of a transplanted syngeneic small bowel

scientific article

Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus

scientific article published in June 2005

Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/Reperfusion Injury ⬇️

scientific article published on October 1, 2003

Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice

scientific article

Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation

scientific article published on 15 April 2021

Carbon Monoxide and the brain: time to rethink the dogma ⬇️

scientific article published on January 1, 2013

Carbon monoxide abrogates ischemic insult to neuronal cells via the soluble guanylate cyclase-cGMP pathway

scientific article

Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway

scientific article

Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance

scientific article published on 22 December 2012

Carbon monoxide enhances early liver regeneration in mice after hepatectomy ⬇️

scientific article published on June 1, 2011

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth

scientific article published on 11 October 2013

Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs

scientific article

Carbon monoxide in biology and medicine

scientific article published on March 2004

Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages

scientific article

Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration

scientific article

Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects

scientific article published on July 2003

Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.

scientific article published on 23 October 2002

Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway

scientific article

Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway

scientific article published in November 2002

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

scientific article published on 30 October 2014

Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule

scientific article published on 27 July 2009

Carbon monoxide orchestrates a protective response through PPARgamma.

scientific article published in May 2006

Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.

scientific article published in June 2005

Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells

scientific article published on 27 July 2004

Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver

scientific article published on 4 March 2004

Carbon monoxide protects against hemorrhagic shock and resuscitation-induced microcirculatory injury and tissue injury

scientific article

Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.

scientific article

Carbon monoxide protects against the development of experimental necrotizing enterocolitis

scientific article

Carbon monoxide protects the kidney through the central circadian clock and CD39.

scientific article published on 20 February 2018

Carbon monoxide reverses established pulmonary hypertension

scientific article

Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

scientific article published on 30 January 2007

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

scientific article published on 21 January 2003

Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule

scientific article

Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli

scientific article published on 24 June 2019

Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.

scientific article published on 09 June 2009

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

scientific article

Characterization of pulmonary immune responses to hyperoxia by high-dimensional mass cytometry analyses

scientific article published on 13 March 2020

Clinical Implications of Hyperoxia

scientific article published in January 2018

Correction: Carbon Monoxide Abrogates Ischemic Insult to Neuronal Cells via the Soluble Guanylate Cyclase-cGMP Pathway

scientific article (publication date: November 2013)

Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways

scientific article

Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice

scientific article published on 21 March 2003

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway

scientific article published on 05 April 2019

Differential modulation by exogenous carbon monoxide of TNF-alpha stimulated mitogen-activated protein kinases in rat pulmonary artery endothelial cells

scientific article published on 01 April 2002

Eat to Heal: Natural Inducers of the Heme Oxygenase-1 System

Emerging role of carbon monoxide in physiologic and pathophysiologic states

scientific article published on 01 April 2002

Endotoxin Engages Mitochondrial Quality Control via an iNOS-Reactive Oxygen Species Signaling Pathway in Hepatocytes

scientific article published on 24 October 2019

Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide.

scientific article published on 14 May 2018

Escherichia coli heme oxygenase modulates host innate immune responses

scientific article

Essential roles of Raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin

scientific article

Failure of Fibrotic Liver Regeneration in Mice Is Linked to a Severe Fibrogenic Response Driven by Hepatic Progenitor Cell Activation ⬇️

scientific article published on May 14, 2013

Friend or foe? Carbon monoxide and the mitochondria

scientific article

Generation of Carbon Monoxide Releasing Molecules (CO-RMs) as Drug Candidates for the Treatment of Acute Liver Injury: Targeting of CO-RMs to the Liver

Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase ⬇️

scientific article published on March 16, 2012

HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease

article

Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury

article

Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival

scientific article

Heme as a danger molecule in pathogen recognition

scientific article published on 08 October 2015

Heme oxygenase and carbon monoxide initiate homeostatic signaling

scientific article

Heme oxygenase and carbon monoxide protect from muscle dystrophy

scientific article

Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein ⬇️

scientific article published on August 17, 2011

Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota

scientific article

Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice

scientific article

Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules ⬇️

scientific article published on July 26, 2012

Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury

scientific article published on 20 February 2004

Heme oxygenase-1: a metabolic nike

scientific article published on 27 February 2014

Heme oxygenase-1: unleashing the protective properties of heme

scientific article

Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance

scientific article

Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes

scientific article

Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning

scholarly article

Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma

scientific article

Induction of protective genes leads to islet survival and function

scientific article published on 14 December 2011

Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion

scientific article published on 28 October 2004

Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation

scientific article published on 11 March 2008

Inhaled carbon monoxide inhibits intimal hyperplasia and provides added benefit with nitric oxide

scientific article published in July 2006

Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine

scientific article published on 29 December 2006

Inhaled carbon monoxide provides cerebral cytoprotection in pigs

scientific article

Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine

scientific article published in February 2003

Innate immunity for better or worse govern the allograft response

scientific article published on February 2015

Intraoperative oxygen concentration and neurocognition after cardiac surgery: study protocol for a randomized controlled trial

scientific article published on 19 December 2017

Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns

scientific article published on May 2017

Low-dose carbon monoxide reduces airway hyperresponsiveness in mice

scientific article published in August 2003

MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury

scientific article published in December 2003

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation

scientific article

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

scientific article

Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

scientific article published on 24 March 2017

Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways

scientific article

Mitochondrial damage-associated molecular patterns from fractures suppress pulmonary immune responses via formyl peptide receptors 1 and 2

scientific article

Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury

scientific article published on 18 January 2010

Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses

scientific article published on April 2013

Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients

scientific article published on 19 July 2013

Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both

scientific article published in February 2005

Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide

scientific article

Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts

scientific article published on 01 August 2003

Pulmonary Natural Killer T Cells Play an Essential Role in Mediating Hyperoxic Acute Lung Injury ⬇️

scientific article published on May 1, 2013

Quoth the Raven: carbon monoxide and nothing more ⬇️

scientific article published on 06 March 2013

Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide

scientific article published on 23 August 2002

Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1

scientific article published on 11 July 2003

The evolution of carbon monoxide into medicine.

scientific article published on July 2009

The molecular basis for the immunomodulatory activities of unconjugated bilirubin

scientific article published on 19 October 2013

The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises

scientific article published on 5 April 2017

The saga of leucine zippers continues: in response to oxidative stress

scientific article published in February 2002

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism

scientific article

The social network of carbon monoxide in medicine ⬇️

scientific article published on November 8, 2012

The therapeutic potential of carbon monoxide

scientific article (publication date: September 2010)

Toll-like receptor 4 suppression leads to islet allograft survival

scientific article published on 2 May 2007

Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?

scholarly article by Christopher P. Hopper et al published 11 October 2018 in Current Pharmaceutical Design

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