List of works - Hiroshi Inoue

Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1

scientific article

CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status

scientific article

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.

scientific article

CRTC3 links catecholamine signalling to energy balance

scientific journal article

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.

scientific article published on 2 March 2016

Central insulin-mediated regulation of hepatic glucose production [Review].

scientific article published on 08 October 2015

Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.

scientific article published on 30 November 2016

Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner

scientific article published on 19 May 2018

Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids

scientific article published in PLoS ONE

Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.

scientific article

ER stress-inducible ATF3 suppresses BMP2-induced ALP expression and activation in MC3T3-E1 cells

scientific article published on 6 December 2013

Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia

scientific article published on 27 June 2016

Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.

scientific article published on 28 November 2011

Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.

scientific article published on 23 February 2015

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action ⬇️

scientific article published on 08 March 2013

Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice

scientific article published on 6 March 2013

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.

scientific article published on 23 September 2014

Identification of de novo STAT3 target gene in liver regeneration.

scientific article published on 16 November 2007

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.

scientific article published on 19 September 2014

PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity

scientific article published on 25 January 2017

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

scientific journal article

Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity

scientific article published on 19 June 2015

Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.

scientific article published on 31 January 2007

Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action ⬇️

scientific article

Role of Krüppel-like factor 15 in PEPCK gene expression in the liver.

scientific article

Role of hepatic STAT3 in the regulation of lipid metabolism.

scientific article published on 30 October 2008

Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.

scientific article published on 2 January 2018

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms ⬇️

scientific article published on October 1, 2003

The Creb1 coactivator Crtc1 is required for energy balance and fertility

scientific article

The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

scientific article

The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.

scientific article

p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model

scientific article

List of works by Hiroshi Inoue

Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1

CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.

CRTC3 links catecholamine signalling to energy balance

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.

Central insulin-mediated regulation of hepatic glucose production [Review].

Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.

Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner

Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids

Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.

ER stress-inducible ATF3 suppresses BMP2-induced ALP expression and activation in MC3T3-E1 cells

Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia

Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.

Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action ⬇️

Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.

Identification of de novo STAT3 target gene in liver regeneration.

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.

PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity

Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.

Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action ⬇️

Role of Krüppel-like factor 15 in PEPCK gene expression in the liver.

Role of hepatic STAT3 in the regulation of lipid metabolism.

Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms ⬇️

The Creb1 coactivator Crtc1 is required for energy balance and fertility

The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.

p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model