List of works - Vladimir Yarov-Yarovoy

A Computational Pipeline to Predict Cardiotoxicity:From the Atom to the Rhythm

scientific article published on 24 February 2020

A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding Site

scientific article

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

scientific article

A distinct structural mechanism underlies TRPV1 activation by piperine

scientific article published on 15 June 2019

A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel.

scientific article published on 11 April 2017

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.

scientific article

Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function.

scientific article published on July 2016

Allosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium.

scientific article published on 27 July 2011

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

scientific article

Antibodies and venom peptides: new modalities for ion channels

scientific article published on 01 May 2019

Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain.

scientific article published on 29 June 2006

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel

scientific article

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

scientific article published in December 1997

Channels: Sticking to nooks and crannies.

scientific article published in August 2013

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution

scientific article published on 10 September 2015

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

scientific article

Closing in on the resting state of the Shaker K(+) channel.

scientific article published on October 2007

Computational Models for Predictive Cardiac Ion Channel Pharmacology.

scientific article published on 5 August 2014

Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway

scientific article published on 16 November 2011

Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells

scientific article published on 08 April 2020

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation.

scholarly article

Editorial

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

scientific article published on 29 November 2021

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.

scientific article

Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

scientific article published on 5 April 2017

Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor ⬇️

scientific article published on October 31, 2011

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

scientific article

In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors.

scientific article published on 20 March 2017

Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose.

scientific article published on 13 June 2007

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin.

scientific article published on 29 December 2011

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

scientific article

Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels

scientific article

Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor ⬇️

scientific article published on August 29, 2011

Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels

scientific article published on 30 December 2015

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

scientific article published in January 2001

Multipass membrane protein structure prediction using Rosetta

scientific article

Na+ channel function, regulation, structure, trafficking and sequestration

scientific article

Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction

scientific article

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

scientific article published on 09 November 2020

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

scientific article published on 17 July 2019

Overview of molecular relationships in the voltage-gated ion channel superfamily.

scientific article

Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4

scientific article published on 01 August 2019

Potassium channels in the heart: structure, function and regulation.

scientific article published on 13 November 2016

Rational design and validation of a vanilloid-sensitive TRPV2 ion channel

scientific article published on 13 June 2016

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

scientific article

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.

scientific article published on 12 March 2012

Sensitivity to the two peptide bacteriocin plantaricin EF is dependent on CorC, a membrane-bound, magnesium/cobalt efflux protein

scientific article published on 19 March 2019

Sequential formation of ion pairs during activation of a sodium channel voltage sensor

scientific article

State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate

scientific article published on 01 May 1998

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

scientific article

Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore

scientific article

Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel

scientific article published on 06 February 2019

Structural basis for gating charge movement in the voltage sensor of a sodium channel

scientific article published on 12 December 2011

Structural insights into TRPV2 activation by small molecules

scientific article published on 28 April 2022

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

scientific article published on 8 June 2015

Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers

scientific article published on 22 July 2019

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

scientific article published on November 2010

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

scientific article

Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels

scientific article

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels.

scientific article published on 7 May 2015

The Sodium Channel Voltage Sensor Slides to Rest

scientific article published on 05 September 2019

The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

scientific article published on 20 September 2019

The bipolar assembly domain of the mitotic motor kinesin-5

scientific article

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

scientific article published in Nature Communications

The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol

scientific article published on 01 August 1997

Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core

scientific article published on 07 April 2021

Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels

scientific article published on 17 January 2020

Voltage-gated ion channels and gating modifier toxins.

scientific article

α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2.

scientific article published on 27 January 2020

List of works by Vladimir Yarov-Yarovoy

A Computational Pipeline to Predict Cardiotoxicity:From the Atom to the Rhythm

A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding Site

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

A distinct structural mechanism underlies TRPV1 activation by piperine

A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel.

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.

Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function.

Allosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium.

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

Antibodies and venom peptides: new modalities for ion channels

Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain.

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

Channels: Sticking to nooks and crannies.

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Closing in on the resting state of the Shaker K(+) channel.

Computational Models for Predictive Cardiac Ion Channel Pharmacology.

Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway

Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation.

Editorial

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.

Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor ⬇️

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors.

Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose.

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin.

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels

Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor ⬇️

Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

Multipass membrane protein structure prediction using Rosetta

Na+ channel function, regulation, structure, trafficking and sequestration

Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

Overview of molecular relationships in the voltage-gated ion channel superfamily.

Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4

Potassium channels in the heart: structure, function and regulation.

Rational design and validation of a vanilloid-sensitive TRPV2 ion channel

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.

Sensitivity to the two peptide bacteriocin plantaricin EF is dependent on CorC, a membrane-bound, magnesium/cobalt efflux protein

Sequential formation of ion pairs during activation of a sodium channel voltage sensor

State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore

Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel

Structural basis for gating charge movement in the voltage sensor of a sodium channel

Structural insights into TRPV2 activation by small molecules

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels.

The Sodium Channel Voltage Sensor Slides to Rest

The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

The bipolar assembly domain of the mitotic motor kinesin-5

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol

Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core

Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels

Voltage-gated ion channels and gating modifier toxins.

α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2.