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List of works by Raul M Luque

A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors

scientific article published on 17 October 2019

A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.

scientific article

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance

scientific article

A plasma circulating miRNAs profile predicts type 2 diabetes mellitus and prediabetes: from the CORDIOPREV study

scientific article published on 26 December 2018

A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs

scientific article published on 16 March 2010

Adipokines (Leptin, Adiponectin, Resistin) Differentially Regulate All Hormonal Cell Types in Primary Anterior Pituitary Cell Cultures from Two Primate Species

scientific article published on 6 March 2017

Adipokines and Their Receptors Are Widely Expressed and Distinctly Regulated by the Metabolic Environment in the Prostate of Male Mice: Direct Role Under Normal and Tumoral Conditions

scientific article

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

scientific article published on 23 June 2019

Association between dopamine and somatostatin receptor expression and pharmacological response to somatostatin analogues in acromegaly.

scientific article published on 21 December 2017

Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas.

scientific article

BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas

scientific article published on 09 February 2017

Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms

scientific article published on 12 March 2019

Both estrogen receptor α and β stimulate pituitary GH gene expression.

scientific article published on January 2013

Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients.

scientific article published on 23 August 2017

CE-MS-based urinary biomarkers to distinguish non-significant from significant prostate cancer

scientific article published on 16 May 2019

Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study

scientific article published on 13 November 2018

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

scientific article published on 22 November 2019

Clinical and functional implication of the components of somatostatin system in gastroenteropancreatic neuroendocrine tumors.

scientific article published in December 2017

Clinical association of metabolic syndrome, C-reactive protein and testosterone levels with clinically significant prostate cancer

scientific article published on 18 November 2018

Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles

scientific article published in Scientific Reports

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

scientific article published on 4 October 2011

Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells

scientific article published on 24 September 2018

Cortistatin: A new link between the growth hormone/prolactin axis, stress, and metabolism.

scientific article published on 22 January 2017

Desmopressin test in the diagnosis and follow-up of cyclical Cushing's disease.

scientific article published on 30 October 2013

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

scientific article published on 17 November 2020

Dietary fat alters the expression of cortistatin and ghrelin systems in the PBMCs of elderly subjects: putative implications in the postprandial inflammatory response

scientific article published on 28 July 2014

Differential Expression of MicroRNAs in Silent and Functioning Corticotroph Tumors

scientific article published on 12 June 2020

Differential contribution of nitric oxide and cGMP to the stimulatory effects of growth hormone-releasing hormone and low-concentration somatostatin on growth hormone release from somatotrophs.

scientific article published in September 2005

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

scientific article

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

scientific article published on 02 December 2021

Dysregulation of the Splicing Machinery Is Associated to the Development of Nonalcoholic Fatty Liver Disease

scientific article published on 01 August 2019

Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer

scientific article published on 03 January 2020

E-cadherin expression is associated with somatostatin analogue response in acromegaly

scientific article published on 06 March 2019

Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice.

scientific article

Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors

scientific article published on 01 June 2019

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice

scientific article

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

scientific article published on 11 October 2011

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

scientific article published on 21 May 2013

Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways.

scientific article published in August 2006

Evidence that ghrelin is as potent as growth hormone (GH)-releasing hormone (GHRH) in releasing GH from primary pituitary cell cultures of a nonhuman primate (Papio anubis), acting through intracellular signaling pathways distinct from GHRH.

scientific article

Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis.

scientific article published in August 2006

Expression analysis of dopamine receptor subtypes in normal human pituitaries, nonfunctioning pituitary adenomas and somatotropinomas, and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acrome

scientific article published on 17 March 2009

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

scientific article published in January 2010

Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: evidence for apoptotic action of kisspeptin-10

scientific article published on 17 December 2010

Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients.

scientific article published on January 2010

Familial isolated pituitary adenoma caused by a Aip gene mutation not described before in a family context

scientific article published on 01 December 2013

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

scientific article published on 9 June 2016

Gender-dependent role of endogenous somatostatin in regulating growth hormone-axis function in mice.

scientific article published on 30 August 2007

Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker.

scientific article published on 27 September 2016

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight.

scientific article published on 02 December 2013

Ghrelin induces growth hormone (GH) secretion via nitric oxide (NO)/cGMP signaling

scientific article published on 01 April 2005

Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway.

scientific article

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors

scientific article published on 08 October 2018

Homologous and heterologous in vitro regulation of pig pituitary somatostatin receptor subtypes, sst1, sst2 and sst5 mRNA.

scientific article published in April 2004

Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).

scientific article published on 22 November 2011

Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors

scientific article published on 28 April 2009

Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.

scientific article published on May 2007

Identification of the somatostatin receptor subtypes (sst) mediating the divergent, stimulatory/inhibitory actions of somatostatin on growth hormone secretion.

scientific article

Imaging and Manipulating Pituitary Function in the Awake Mouse

scientific article published on 01 October 2019

Impact of gsp Oncogene on the mRNA Content for Somatostatin and Dopamine Receptors in Human Somatotropinomas

scientific article published on 13 November 2010

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

scientific journal article

In1-ghrelin splicing variant is associated with reduced disease-free survival of breast cancer patients and increases malignancy of breast cancer cells lines

scientific article published on 19 December 2017

In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features.

scientific article

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters

scientific article

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

scientific article published on 13 May 2013

Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes.

scientific article published on 28 August 2003

Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms

scientific article

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.

scientific article published on 8 March 2016

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

scientific article published on 16 December 2013

Long-term dietary adherence and changes in dietary intake in coronary patients after intervention with a Mediterranean diet or a low-fat diet: the CORDIOPREV randomized trial

scientific article published on 24 July 2019

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates

scientific article

Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion.

scientific article published on 18 May 2015

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

scientific article

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach.

scientific article published on 23 December 2009

Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways

scientific article published on 6 April 2017

Models of GH deficiency in animal studies.

scientific article published on 4 November 2016

Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly

scientific article

Molecular evidence and clinical importance of β-arrestins expression in patients with acromegaly.

scientific article

Mouse models in endocrine tumors

scientific article published on 01 November 2018

Multilayered heterogeneity as an intrinsic hallmark of neuroendocrine tumors

article

Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

scientific article published on 15 December 2017

Neuronostatin exerts actions on pituitary that are unique from its sibling peptide somatostatin.

scientific article published on 3 April 2018

New insights in the mechanism by which SRIF influences GH secretion.

scientific article

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels

scientific article published in April 2015

Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue.

scientific article

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin

scientific article

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.

scientific article published on 28 February 2017

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

scientific article

Obesity-induced hypogonadism in the male: premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms

scientific article published on January 2014

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

scientific article published on 31 January 2014

Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation.

scientific article published on 17 May 2012

Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro.

scientific article published in September 2016

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

scientific article published on 06 September 2019

Peptides derived from the extracellular domain of the somatostatin receptor splicing variant SST5TMD4 increase malignancy in multiple cancer cell types

scientific article published on 02 March 2019

Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity ⬇️

scientific article published on August 28, 2012

Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer

scientific article published on 06 September 2018

Porcine sst1 can physically interact with other somatostatin receptors, and its expression is regulated by metabolic/inflammatory sensors.

scientific article published on 24 December 2013

Prediabetes diagnosis criteria, type 2 diabetes risk and dietary modulation: The CORDIOPREV study

scientific article published on 21 February 2019

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.

scientific article published on 11 December 2015

Quantitative analysis of somatostatin receptor subtype (SSTR1–5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas

article

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas

scientific article published on 01 May 2019

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas

scientific article published on 28 March 2019

Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue

scientific article published on 25 October 2011

Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland.

scientific article published on 8 February 2007

Research progress in the stimulatory inputs regulating growth hormone (GH) secretion.

scientific article

Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions

scientific article

Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes.

scientific article published on 14 December 2007

Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.

scientific article published on October 2011

Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function.

scientific article

SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances

scientific article published on 27 January 2022

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

scientific article published on 23 August 2016

Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotropin-releasing hormone.

scientific article published on 12 October 2006

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice ⬇️

scientific article published on October 13, 2010

Somatostatin and its receptors from fish to mammals.

scientific article

Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.

scientific article

Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer.

scientific article

Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study.

scientific article published on 10 November 2010

Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF.

scientific article published on 19 August 2014

Spliceosome component SF3B1 as novel prognostic biomarker and therapeutic target for prostate cancer

scientific article published on 09 July 2019

Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features

scientific article published on 26 September 2019

Targeted Systemic Treatment of Neuroendocrine Tumors: Current Options and Future Perspectives.

scientific article published in January 2019

Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model

scientific article

The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research.

scientific article published on 15 April 2016

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

scientific article published on 11 September 2018

The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration

scientific article published on 19 April 2012

The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.

scientific article published on 13 May 2017

The expression of the truncated isoform of somatostatin receptor subtype 5 associates with aggressiveness in medullary thyroid carcinoma cells

scientific article

The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

scientific article published on 29 August 2017

The oncogenic role of the spliced somatostatin receptor sst5TMD4 variant in prostate cancer.

scientific article published on 13 July 2017

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice

scientific article

The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.

scientific article

The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer

scientific article published on 21 January 2014

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

scientific article published on 05 August 2016

Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues — Observations in two patients with acromegaly and severe headache

article

Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas

scientific article

Truncated somatostatin receptors as new players in somatostatin–cortistatin pathophysiology ⬇️

scientific article published on March 1, 2011

Truncated variants of pig somatostatin receptor subtype 5 (sst5) act as dominant-negative modulators for sst2-mediated signaling.

scientific article published on 2 October 2012

Type 2 Diabetes in Neuroendocrine Tumors: Are Biguanides and Statins Part of the Solution?

scientific article published on 01 January 2019

Understanding the multifactorial control of growth hormone release by somatotropes: lessons from comparative endocrinology.

scientific article published on April 2009

Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer

scientific article published on 02 June 2020

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.

scientific article published on 02 April 2009

Variability in quantitative expression of receptors in nonfunctioning pituitary macroadenomas--an opportunity for targeted medical therapy.

scientific article published on January 2014

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